Progress of CCL20-CCR6 in the airways: a promising new therapeutic target
Abstract The chemokine CCL20, a small cytokine that belongs to the C–C chemokine family, interacts with its homologous receptor CCR6, which is expressed on wide range of cell types. According to current research, the CCL20-CCR6 has been established as acritical player in a diverse range of inflammat...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Journal of Inflammation |
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| Online Access: | https://doi.org/10.1186/s12950-024-00427-5 |
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| author | Ya -Jing Li Wan-Li Geng Chen-Chen Li Jia-Hao Wu Fei Gao Yong Wang |
| author_facet | Ya -Jing Li Wan-Li Geng Chen-Chen Li Jia-Hao Wu Fei Gao Yong Wang |
| author_sort | Ya -Jing Li |
| collection | DOAJ |
| description | Abstract The chemokine CCL20, a small cytokine that belongs to the C–C chemokine family, interacts with its homologous receptor CCR6, which is expressed on wide range of cell types. According to current research, the CCL20-CCR6 has been established as acritical player in a diverse range of inflammatory, oncogenic, and autoimmune diseases. Within the respiratory system, CCL20-CCR6 demonstrates heightened expression in conditions such as allergic asthma, chronic airway inflammation, non-small cell lung cancer (NSCLC), chronic obstructive pulmonary disease (COPD), and other respiratory diseases, which is conducive to the inflammatory mediators recruitment and tumor microenvironment remodeling. Numerous studies have demonstrated that therapeutic interventions targeting CCL20 and CCR6, including antibodies and antagonists, have the potential to mitigate disease progression. Despite the promising research prospects surrounding the CCL20-CCR6 chemokine axis, the precise mechanisms underlying its action in respiratory diseases remain largely elusive. In this review, we delve into the potential roles of the CCL20-CCR6 axis within the respiratory system by synthesizing and analyzing current research findings. Our objective is to provide a comprehensive understanding of the CCL20-CCR6 axis and its implications for respiratory health and disease. And we aspire to propel research endeavors in this domain and furnish valuable insights for the development of future therapeutic strategies. |
| format | Article |
| id | doaj-art-f3850ccf36684b44b7d46c7228a0c232 |
| institution | Kabale University |
| issn | 1476-9255 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Inflammation |
| spelling | doaj-art-f3850ccf36684b44b7d46c7228a0c2322025-01-19T12:10:17ZengBMCJournal of Inflammation1476-92552024-12-0121111210.1186/s12950-024-00427-5Progress of CCL20-CCR6 in the airways: a promising new therapeutic targetYa -Jing Li0Wan-Li Geng1Chen-Chen Li2Jia-Hao Wu3Fei Gao4Yong Wang5Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical UniversityAbstract The chemokine CCL20, a small cytokine that belongs to the C–C chemokine family, interacts with its homologous receptor CCR6, which is expressed on wide range of cell types. According to current research, the CCL20-CCR6 has been established as acritical player in a diverse range of inflammatory, oncogenic, and autoimmune diseases. Within the respiratory system, CCL20-CCR6 demonstrates heightened expression in conditions such as allergic asthma, chronic airway inflammation, non-small cell lung cancer (NSCLC), chronic obstructive pulmonary disease (COPD), and other respiratory diseases, which is conducive to the inflammatory mediators recruitment and tumor microenvironment remodeling. Numerous studies have demonstrated that therapeutic interventions targeting CCL20 and CCR6, including antibodies and antagonists, have the potential to mitigate disease progression. Despite the promising research prospects surrounding the CCL20-CCR6 chemokine axis, the precise mechanisms underlying its action in respiratory diseases remain largely elusive. In this review, we delve into the potential roles of the CCL20-CCR6 axis within the respiratory system by synthesizing and analyzing current research findings. Our objective is to provide a comprehensive understanding of the CCL20-CCR6 axis and its implications for respiratory health and disease. And we aspire to propel research endeavors in this domain and furnish valuable insights for the development of future therapeutic strategies.https://doi.org/10.1186/s12950-024-00427-5CCL20CCR6ImmunoreactionInflammationRespiratory system |
| spellingShingle | Ya -Jing Li Wan-Li Geng Chen-Chen Li Jia-Hao Wu Fei Gao Yong Wang Progress of CCL20-CCR6 in the airways: a promising new therapeutic target Journal of Inflammation CCL20 CCR6 Immunoreaction Inflammation Respiratory system |
| title | Progress of CCL20-CCR6 in the airways: a promising new therapeutic target |
| title_full | Progress of CCL20-CCR6 in the airways: a promising new therapeutic target |
| title_fullStr | Progress of CCL20-CCR6 in the airways: a promising new therapeutic target |
| title_full_unstemmed | Progress of CCL20-CCR6 in the airways: a promising new therapeutic target |
| title_short | Progress of CCL20-CCR6 in the airways: a promising new therapeutic target |
| title_sort | progress of ccl20 ccr6 in the airways a promising new therapeutic target |
| topic | CCL20 CCR6 Immunoreaction Inflammation Respiratory system |
| url | https://doi.org/10.1186/s12950-024-00427-5 |
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