Functional nanocrystal as effective contrast agents for dual-mode imaging: Live-cell sonoluminescence and contrast-enhanced echography
In the context of molecular imaging, the present work explores an innovative platform made of lipid-coated nanocrystals as contrast-enhanced agent for both ultrasound imaging and sonoluminescence. At first, the dynamics of gas bubbles generation and cavitation under insonation with either pristine o...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Ultrasonics Sonochemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1350417725000215 |
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| author | V. Vighetto E. Pascucci N.M. Percivalle A. Troia K.M. Meiburger M.R.P. van den Broek T. Segers V. Cauda |
| author_facet | V. Vighetto E. Pascucci N.M. Percivalle A. Troia K.M. Meiburger M.R.P. van den Broek T. Segers V. Cauda |
| author_sort | V. Vighetto |
| collection | DOAJ |
| description | In the context of molecular imaging, the present work explores an innovative platform made of lipid-coated nanocrystals as contrast-enhanced agent for both ultrasound imaging and sonoluminescence. At first, the dynamics of gas bubbles generation and cavitation under insonation with either pristine or lipid-coated nanocrystals (ZnO-Lip) are described, and the differences between the two colloidal systems are highlighted. These ZnO-Lip show an unprecedented ability to assist cavitation, which is reflected in enhanced sonoluminescent light emission with respect to the pristine nanocrystals or the pure water. Highly defined and sharp sonoluminescent images of cultured cells are indeed obtained, for the first time, when ZnO-Lip are used. Furthermore, ZnO-Lip were adopted as a nanosized agent for contrast-enhanced ultrasound imaging, i.e. echography, first in solutions, and then on ex-vivo tissues. A prolonged over time and bright imaging effect is observed when adopting the developed nanoparticles. Furthermore, their nanometric size and potential targeting with biomolecules would allow ease extravasation and tissue or even cell penetration, achieving enhanced-contrast imaging. Finally, the stimuli-responsive therapeutic applications of ZnO-Lip against tumors is overviewed, aiming to achieve a fully theranostic approach. |
| format | Article |
| id | doaj-art-f377d1ee7f4f4f4c84f95e4f5dd49b0c |
| institution | Kabale University |
| issn | 1350-4177 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ultrasonics Sonochemistry |
| spelling | doaj-art-f377d1ee7f4f4f4c84f95e4f5dd49b0c2025-02-01T04:11:39ZengElsevierUltrasonics Sonochemistry1350-41772025-02-01113107242Functional nanocrystal as effective contrast agents for dual-mode imaging: Live-cell sonoluminescence and contrast-enhanced echographyV. Vighetto0E. Pascucci1N.M. Percivalle2A. Troia3K.M. Meiburger4M.R.P. van den Broek5T. Segers6V. Cauda7Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy; PolitoBIOMed Lab, Politecnico di Torino, 10129 Turin, ItalyDepartment of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, ItalyDepartment of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, ItalyUltrasounds & Chemistry Lab, Advanced Metrology for Quality of Life, Istituto Nazionale di Ricerca Metrologica (I.N.Ri.M.), Strada delle Cacce 91, 10135 Turin, ItalyPolitoBIOMed Lab, Politecnico di Torino, 10129 Turin, Italy; Department of Electronics and Telecommunications, Politecnico di Torino, 10129 Turin, ItalyBIOS/Lab on a Chip Group, Max-Planck Center Twente for Complex Fluid Dynamics, MESA+ Institute for Nanotechnology, University of Twente, Drienerlolaan 5, 7522 NB Enschede, NetherlandsBIOS/Lab on a Chip Group, Max-Planck Center Twente for Complex Fluid Dynamics, MESA+ Institute for Nanotechnology, University of Twente, Drienerlolaan 5, 7522 NB Enschede, NetherlandsDepartment of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy; PolitoBIOMed Lab, Politecnico di Torino, 10129 Turin, Italy; Corresponding author at: Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy Tel.: +39 011 090 7389.In the context of molecular imaging, the present work explores an innovative platform made of lipid-coated nanocrystals as contrast-enhanced agent for both ultrasound imaging and sonoluminescence. At first, the dynamics of gas bubbles generation and cavitation under insonation with either pristine or lipid-coated nanocrystals (ZnO-Lip) are described, and the differences between the two colloidal systems are highlighted. These ZnO-Lip show an unprecedented ability to assist cavitation, which is reflected in enhanced sonoluminescent light emission with respect to the pristine nanocrystals or the pure water. Highly defined and sharp sonoluminescent images of cultured cells are indeed obtained, for the first time, when ZnO-Lip are used. Furthermore, ZnO-Lip were adopted as a nanosized agent for contrast-enhanced ultrasound imaging, i.e. echography, first in solutions, and then on ex-vivo tissues. A prolonged over time and bright imaging effect is observed when adopting the developed nanoparticles. Furthermore, their nanometric size and potential targeting with biomolecules would allow ease extravasation and tissue or even cell penetration, achieving enhanced-contrast imaging. Finally, the stimuli-responsive therapeutic applications of ZnO-Lip against tumors is overviewed, aiming to achieve a fully theranostic approach.http://www.sciencedirect.com/science/article/pii/S1350417725000215Zinc oxideInertial cavitationSonoluminescenceBubble cavitationEchographic nano-contrast agent |
| spellingShingle | V. Vighetto E. Pascucci N.M. Percivalle A. Troia K.M. Meiburger M.R.P. van den Broek T. Segers V. Cauda Functional nanocrystal as effective contrast agents for dual-mode imaging: Live-cell sonoluminescence and contrast-enhanced echography Ultrasonics Sonochemistry Zinc oxide Inertial cavitation Sonoluminescence Bubble cavitation Echographic nano-contrast agent |
| title | Functional nanocrystal as effective contrast agents for dual-mode imaging: Live-cell sonoluminescence and contrast-enhanced echography |
| title_full | Functional nanocrystal as effective contrast agents for dual-mode imaging: Live-cell sonoluminescence and contrast-enhanced echography |
| title_fullStr | Functional nanocrystal as effective contrast agents for dual-mode imaging: Live-cell sonoluminescence and contrast-enhanced echography |
| title_full_unstemmed | Functional nanocrystal as effective contrast agents for dual-mode imaging: Live-cell sonoluminescence and contrast-enhanced echography |
| title_short | Functional nanocrystal as effective contrast agents for dual-mode imaging: Live-cell sonoluminescence and contrast-enhanced echography |
| title_sort | functional nanocrystal as effective contrast agents for dual mode imaging live cell sonoluminescence and contrast enhanced echography |
| topic | Zinc oxide Inertial cavitation Sonoluminescence Bubble cavitation Echographic nano-contrast agent |
| url | http://www.sciencedirect.com/science/article/pii/S1350417725000215 |
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