Ginsenoside Re ameliorates thioacetamide-induced acute liver injury through inhibiting autophagy-NLRP3 inflammasome pathway

Ginsenoside Re ameliorates thioacetamide-induced acute liver injury through inhibiting autophagy-NLRP3 inflammasome pathway

BackgroundGinsenoside Re (G-Re), a unique ginsenoside almost exclusively found in Araliaceae plants, is a promising therapeutic agent for attenuating liver injury. This study aims to investigate the liver-protective effects of G-Re and the underlying mechanisms in acute liver injury models.MethodsMa...

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Bibliographic Details
Main Authors: Jing Lin, Huan Wang, Ruowei Zhao, Shaohua Li, Dennis Chang, Yanfang Zheng, Xian Zhou, Rui Huang, Mingqing Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
ginsenoside Re
acute liver injury
PI3K/AKT/mTOR
autophagy
NLRP3 inflammasome
male mice
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1592203/full
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