Correlation between the Systemic Immunoinflammatory Index and Platelet–Lymphocyte Ratio in Patients with Adenomyosis
Background. The chronic inflammatory immune response is a significant factor in the pathogenesis of benign gynecological diseases. The systemic immunoinflammatory index (SII) and the platelet-to-lymphocyte ratio (PLR) are commonly available biomarkers of inflammation. However, evidence of the relati...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2024/9977750 |
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| author | Yan Dong YaHui Chen YaNan Wang Lin Wang Yan Zhou Mei Xue Lin Sun |
| author_facet | Yan Dong YaHui Chen YaNan Wang Lin Wang Yan Zhou Mei Xue Lin Sun |
| author_sort | Yan Dong |
| collection | DOAJ |
| description | Background. The chronic inflammatory immune response is a significant factor in the pathogenesis of benign gynecological diseases. The systemic immunoinflammatory index (SII) and the platelet-to-lymphocyte ratio (PLR) are commonly available biomarkers of inflammation. However, evidence of the relationship between SII and PLR in patients with adenomyosis is limited. This study aimed to investigate the relationship between SII and PLR in patients with adenomyosis. Methods. This cross-sectional study included 483 patients with adenomyosis who were first diagnosed at our institution between January 2019 and December 2021. Basic patient clinical information and inflammatory factors were collected for univariate analysis, smoothed curve fitting, and multivariate segmented linear regression. Results. The results of the univariate analysis showed a significant positive correlation between PLR levels and SII (P<0.001). In addition, a nonlinear relationship between PLR and SII was tested using a smoothed curve fit after adjusting for potential confounders. Multiple segmented linear regression models showed a significant relationship between SII and PLR in both SII < 1,326.47 (β 0.14, 95% CI: 0.12, 0.16; P<0.0001) and >1,326.47 (β 0.02, 95% CI: −0.01, 0.05; P = 0.2461). Conclusions. In conclusion, this study showed a nonlinear relationship between SII and PLR in patients with uterine adenomyosis. An increase in serum PLR levels correlates with an increase in SII before SII levels reach an inflection point. |
| format | Article |
| id | doaj-art-f3749999df444fea8c10e557ce2ad4e3 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-f3749999df444fea8c10e557ce2ad4e32025-02-03T11:53:48ZengWileyMediators of Inflammation1466-18612024-01-01202410.1155/2024/9977750Correlation between the Systemic Immunoinflammatory Index and Platelet–Lymphocyte Ratio in Patients with AdenomyosisYan Dong0YaHui Chen1YaNan Wang2Lin Wang3Yan Zhou4Mei Xue5Lin Sun6Department of Gynecology and ObstetricsJining Medical UniversityJining Medical UniversityJining Medical UniversityJining Medical UniversityJining Medical UniversityDepartment of Gynecology and ObstetricsBackground. The chronic inflammatory immune response is a significant factor in the pathogenesis of benign gynecological diseases. The systemic immunoinflammatory index (SII) and the platelet-to-lymphocyte ratio (PLR) are commonly available biomarkers of inflammation. However, evidence of the relationship between SII and PLR in patients with adenomyosis is limited. This study aimed to investigate the relationship between SII and PLR in patients with adenomyosis. Methods. This cross-sectional study included 483 patients with adenomyosis who were first diagnosed at our institution between January 2019 and December 2021. Basic patient clinical information and inflammatory factors were collected for univariate analysis, smoothed curve fitting, and multivariate segmented linear regression. Results. The results of the univariate analysis showed a significant positive correlation between PLR levels and SII (P<0.001). In addition, a nonlinear relationship between PLR and SII was tested using a smoothed curve fit after adjusting for potential confounders. Multiple segmented linear regression models showed a significant relationship between SII and PLR in both SII < 1,326.47 (β 0.14, 95% CI: 0.12, 0.16; P<0.0001) and >1,326.47 (β 0.02, 95% CI: −0.01, 0.05; P = 0.2461). Conclusions. In conclusion, this study showed a nonlinear relationship between SII and PLR in patients with uterine adenomyosis. An increase in serum PLR levels correlates with an increase in SII before SII levels reach an inflection point.http://dx.doi.org/10.1155/2024/9977750 |
| spellingShingle | Yan Dong YaHui Chen YaNan Wang Lin Wang Yan Zhou Mei Xue Lin Sun Correlation between the Systemic Immunoinflammatory Index and Platelet–Lymphocyte Ratio in Patients with Adenomyosis Mediators of Inflammation |
| title | Correlation between the Systemic Immunoinflammatory Index and Platelet–Lymphocyte Ratio in Patients with Adenomyosis |
| title_full | Correlation between the Systemic Immunoinflammatory Index and Platelet–Lymphocyte Ratio in Patients with Adenomyosis |
| title_fullStr | Correlation between the Systemic Immunoinflammatory Index and Platelet–Lymphocyte Ratio in Patients with Adenomyosis |
| title_full_unstemmed | Correlation between the Systemic Immunoinflammatory Index and Platelet–Lymphocyte Ratio in Patients with Adenomyosis |
| title_short | Correlation between the Systemic Immunoinflammatory Index and Platelet–Lymphocyte Ratio in Patients with Adenomyosis |
| title_sort | correlation between the systemic immunoinflammatory index and platelet lymphocyte ratio in patients with adenomyosis |
| url | http://dx.doi.org/10.1155/2024/9977750 |
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