Pharmacological and Other Interventions for Head and Neck Cancer Pain: a Systematic Review
Objectives: Pain is a common complication in head and neck cancer. The aim of this paper is to evaluate the evidence from randomised control trials investigating pharmacological and non-pharmacological methods of pain management in head and neck cancer. Material and Methods: Medline, Embase and the...
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| Format: | Article |
| Language: | English |
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Lithuanian University of Health Sciences, Faculty of Odontology
2012-12-01
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| Series: | eJournal of Oral Maxillofacial Research |
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| Online Access: | http://www.ejomr.org/JOMR/archives/2012/4/e1/v3n4e1ht.htm |
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| author | Patrick B. Trotter Lindsey A. Norton Ann S. Loo Jonathan I. Munn Elena Voge Kim W. Ah-See Tatiana V. Macfarlane |
| author_facet | Patrick B. Trotter Lindsey A. Norton Ann S. Loo Jonathan I. Munn Elena Voge Kim W. Ah-See Tatiana V. Macfarlane |
| author_sort | Patrick B. Trotter |
| collection | DOAJ |
| description | Objectives: Pain is a common complication in head and neck cancer. The aim of this paper is to evaluate the evidence from randomised control trials investigating pharmacological and non-pharmacological methods of pain management in head and neck cancer. Material and Methods: Medline, Embase and the Cochrane library databases were searched. Squamous cell carcinomas of the head and neck excluding nasopharyngeal and salivary gland cancers were included. The limits were “human” and “randomised clinical trials”. A quality assessment was carried out. Results: 13 studies were included with a total of 644 participants. The primary outcome for most of these papers was pain control post-treatment. Levels of bias varied between the studies. Majority (12 out of the 13 studies) reported intervention to be superior to the control or standard therapy in pain management. Only 46% of the studies were carried out on an intention to treat basis. Two studies reported high dropout rates, with one at 66%. Conclusions: There is insufficient evidence from randomised clinical trials to suggest an optimal pharmacological intervention for head and neck cancer pain post-treatment. Further high quality randomised clinical trials should be conducted to develop an optimal management strategy for head and neck cancer pain. |
| format | Article |
| id | doaj-art-f3719d6ea9d24888bccd6bfefda3e5ee |
| institution | DOAJ |
| issn | 2029-283X |
| language | English |
| publishDate | 2012-12-01 |
| publisher | Lithuanian University of Health Sciences, Faculty of Odontology |
| record_format | Article |
| series | eJournal of Oral Maxillofacial Research |
| spelling | doaj-art-f3719d6ea9d24888bccd6bfefda3e5ee2025-08-20T03:22:42ZengLithuanian University of Health Sciences, Faculty of OdontologyeJournal of Oral Maxillofacial Research2029-283X2012-12-0134e110.5037/jomr.2012.3401Pharmacological and Other Interventions for Head and Neck Cancer Pain: a Systematic ReviewPatrick B. TrotterLindsey A. NortonAnn S. LooJonathan I. MunnElena VogeKim W. Ah-SeeTatiana V. MacfarlaneObjectives: Pain is a common complication in head and neck cancer. The aim of this paper is to evaluate the evidence from randomised control trials investigating pharmacological and non-pharmacological methods of pain management in head and neck cancer. Material and Methods: Medline, Embase and the Cochrane library databases were searched. Squamous cell carcinomas of the head and neck excluding nasopharyngeal and salivary gland cancers were included. The limits were “human” and “randomised clinical trials”. A quality assessment was carried out. Results: 13 studies were included with a total of 644 participants. The primary outcome for most of these papers was pain control post-treatment. Levels of bias varied between the studies. Majority (12 out of the 13 studies) reported intervention to be superior to the control or standard therapy in pain management. Only 46% of the studies were carried out on an intention to treat basis. Two studies reported high dropout rates, with one at 66%. Conclusions: There is insufficient evidence from randomised clinical trials to suggest an optimal pharmacological intervention for head and neck cancer pain post-treatment. Further high quality randomised clinical trials should be conducted to develop an optimal management strategy for head and neck cancer pain.http://www.ejomr.org/JOMR/archives/2012/4/e1/v3n4e1ht.htmhead and neck neoplasmspainpostoperativeanalgesicsopioidpain measurementsystematic review. |
| spellingShingle | Patrick B. Trotter Lindsey A. Norton Ann S. Loo Jonathan I. Munn Elena Voge Kim W. Ah-See Tatiana V. Macfarlane Pharmacological and Other Interventions for Head and Neck Cancer Pain: a Systematic Review eJournal of Oral Maxillofacial Research head and neck neoplasms pain postoperative analgesics opioid pain measurement systematic review. |
| title | Pharmacological and Other Interventions for Head and Neck Cancer Pain: a Systematic Review |
| title_full | Pharmacological and Other Interventions for Head and Neck Cancer Pain: a Systematic Review |
| title_fullStr | Pharmacological and Other Interventions for Head and Neck Cancer Pain: a Systematic Review |
| title_full_unstemmed | Pharmacological and Other Interventions for Head and Neck Cancer Pain: a Systematic Review |
| title_short | Pharmacological and Other Interventions for Head and Neck Cancer Pain: a Systematic Review |
| title_sort | pharmacological and other interventions for head and neck cancer pain a systematic review |
| topic | head and neck neoplasms pain postoperative analgesics opioid pain measurement systematic review. |
| url | http://www.ejomr.org/JOMR/archives/2012/4/e1/v3n4e1ht.htm |
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