Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi Imunohistokimia
Inflammatory cytokines have a role in triggering cell signals in colorectal cancer. They increase signaling pathways into cells via the Janus kinase pathway (JAK) - signal transducer and activator of transcription (STAT) -suppressor of cytokine signaling (SOCs) JAK-STAT. SOCs2 protein is a cytoplasm...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine at Universitas Andalas
2022-07-01
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| Series: | Jurnal Kesehatan Andalas |
| Online Access: | http://jurnal.fk.unand.ac.id/index.php/jka/article/view/1982 |
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| author | Nita Afriani Azmal Shinta Ayu Intan Tofrizal Tofrizal |
| author_facet | Nita Afriani Azmal Shinta Ayu Intan Tofrizal Tofrizal |
| author_sort | Nita Afriani Azmal |
| collection | DOAJ |
| description | Inflammatory cytokines have a role in triggering cell signals in colorectal cancer. They increase signaling pathways into cells via the Janus kinase pathway (JAK) - signal transducer and activator of transcription (STAT) -suppressor of cytokine signaling (SOCs) JAK-STAT. SOCs2 protein is a cytoplasmic protein that can inhibit activation of JAK-STAT pathway so that it prevents cascade of signals into the nucleus. This protein is thought to have decreased in adenocarcinoma colorectal. Objectives: To reveal the expression of SOCs2 protein in 37 paraffin block samples in Anatomy Pathology Department Medical Faculty Andalas University. Methods: Data were taken from medical records and histopathology was assessed by HE. SOCs2 expression was evaluated by immunohistochemistry using SOCs2 polyclonal antibody (bs-1896R). Cytoplasmic expression was counted using Image J software. Results: The average of age was 56.57 years, 21 samples (55.8%) were male, depth of invasion was mostly in the tunica muscularis (T3), and 7 cases of malignancy (18.9%) were poorly differentiated. SOCs2 expression was 5 cases (13.5%). Conclusion: There was SOCs2 expression in a small proportion of colorectal adenocarcinoma.
Keywords: SOCs2 protein, cytoplasmic inhibitor, JAK-STAT, cell signaling |
| format | Article |
| id | doaj-art-f368662ce9054f2eb6b2144312cc72eb |
| institution | Kabale University |
| issn | 2301-7406 2615-1138 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Faculty of Medicine at Universitas Andalas |
| record_format | Article |
| series | Jurnal Kesehatan Andalas |
| spelling | doaj-art-f368662ce9054f2eb6b2144312cc72eb2025-02-03T08:18:25ZengFaculty of Medicine at Universitas AndalasJurnal Kesehatan Andalas2301-74062615-11382022-07-011111710.25077/jka.v11i1.19821206Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi ImunohistokimiaNita Afriani Azmal0Shinta Ayu Intan1Tofrizal Tofrizal2Histology Department, Faculty of Medicine, Universitas Andalas, Padang.Anatomic Pathology Department, Faculty of Medicine, Universitas Andalas, Padang.Anatomic Pathology Department, Faculty of Medicine, Universitas Andalas, Padang.Inflammatory cytokines have a role in triggering cell signals in colorectal cancer. They increase signaling pathways into cells via the Janus kinase pathway (JAK) - signal transducer and activator of transcription (STAT) -suppressor of cytokine signaling (SOCs) JAK-STAT. SOCs2 protein is a cytoplasmic protein that can inhibit activation of JAK-STAT pathway so that it prevents cascade of signals into the nucleus. This protein is thought to have decreased in adenocarcinoma colorectal. Objectives: To reveal the expression of SOCs2 protein in 37 paraffin block samples in Anatomy Pathology Department Medical Faculty Andalas University. Methods: Data were taken from medical records and histopathology was assessed by HE. SOCs2 expression was evaluated by immunohistochemistry using SOCs2 polyclonal antibody (bs-1896R). Cytoplasmic expression was counted using Image J software. Results: The average of age was 56.57 years, 21 samples (55.8%) were male, depth of invasion was mostly in the tunica muscularis (T3), and 7 cases of malignancy (18.9%) were poorly differentiated. SOCs2 expression was 5 cases (13.5%). Conclusion: There was SOCs2 expression in a small proportion of colorectal adenocarcinoma. Keywords: SOCs2 protein, cytoplasmic inhibitor, JAK-STAT, cell signalinghttp://jurnal.fk.unand.ac.id/index.php/jka/article/view/1982 |
| spellingShingle | Nita Afriani Azmal Shinta Ayu Intan Tofrizal Tofrizal Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi Imunohistokimia Jurnal Kesehatan Andalas |
| title | Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi Imunohistokimia |
| title_full | Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi Imunohistokimia |
| title_fullStr | Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi Imunohistokimia |
| title_full_unstemmed | Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi Imunohistokimia |
| title_short | Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi Imunohistokimia |
| title_sort | ekspresi protein sitoplasmik socs2 pada adenokarsinoma kolorektal studi imunohistokimia |
| url | http://jurnal.fk.unand.ac.id/index.php/jka/article/view/1982 |
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