Cardiac computed tomography‐derived myocardial tissue characterization after anthracycline treatment
Abstract Aims Understanding cardiac function after anthracycline administration is very important from the perspective of preventing the onset of heart failure. Although cardiac magnetic resonance and echocardiography are recognized as the ‘gold standard’ for detecting cardiotoxicity, they have many...
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.13867 |
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| author | Koichi Egashira Daisuke Sueta Masafumi Kidoh Mai Tomiguchi Seitaro Oda Hiroki Usuku Kaori Hidaka Lisa Goto‐Yamaguchi Aiko Sueta Takashi Komorita Fumi Oike Koichiro Fujisue Eiichiro Yamamoto Shinsuke Hanatani Seiji Takashio Satoshi Araki Kenichi Matsushita Yutaka Yamamoto Toshinori Hirai Kenichi Tsujita |
| author_facet | Koichi Egashira Daisuke Sueta Masafumi Kidoh Mai Tomiguchi Seitaro Oda Hiroki Usuku Kaori Hidaka Lisa Goto‐Yamaguchi Aiko Sueta Takashi Komorita Fumi Oike Koichiro Fujisue Eiichiro Yamamoto Shinsuke Hanatani Seiji Takashio Satoshi Araki Kenichi Matsushita Yutaka Yamamoto Toshinori Hirai Kenichi Tsujita |
| author_sort | Koichi Egashira |
| collection | DOAJ |
| description | Abstract Aims Understanding cardiac function after anthracycline administration is very important from the perspective of preventing the onset of heart failure. Although cardiac magnetic resonance and echocardiography are recognized as the ‘gold standard’ for detecting cardiotoxicity, they have many shortcomings. We aimed to investigate whether cardiac computed tomography (CCT) could replace these techniques, assessing serial changes in cardiac tissue characteristics as determined by CCT after anthracycline administration. Methods and results We prospectively investigated 15 consecutive breast cancer patients who were scheduled to receive anthracycline therapy. We performed echocardiography and CCT before and 3, 6, and 12 months after anthracycline treatment. The mean cumulative administered anthracycline dose was 269.9 ± 14.6 mg/m2 (doxorubicin‐converted dose). Of the 15 enrolled patients who received anthracycline treatment for breast cancer, none met the definition of cardiotoxicity. The CCT‐derived extracellular volume fraction tended to continue to increase after anthracycline treatment and had relatively similar dynamics to the left ventricular ejection fraction and global longitudinal strain as determined by echocardiography. Conclusions Our findings indicated that CCT could provide adequate information about the characteristics of myocardial tissue after anthracycline administration. CCT may improve the understanding of cardiotoxicity by compensating for the weaknesses of echocardiography. This technique could be useful for understanding cardiac tissue characterization as a ‘one‐stop shop’ evaluation, providing new insight into cardiooncology. |
| format | Article |
| id | doaj-art-f36114ce24004c46a20feaca5d87f166 |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-f36114ce24004c46a20feaca5d87f1662025-02-05T05:22:10ZengWileyESC Heart Failure2055-58222022-06-01931792180010.1002/ehf2.13867Cardiac computed tomography‐derived myocardial tissue characterization after anthracycline treatmentKoichi Egashira0Daisuke Sueta1Masafumi Kidoh2Mai Tomiguchi3Seitaro Oda4Hiroki Usuku5Kaori Hidaka6Lisa Goto‐Yamaguchi7Aiko Sueta8Takashi Komorita9Fumi Oike10Koichiro Fujisue11Eiichiro Yamamoto12Shinsuke Hanatani13Seiji Takashio14Satoshi Araki15Kenichi Matsushita16Yutaka Yamamoto17Toshinori Hirai18Kenichi Tsujita19Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University 1‐1‐1, Honjo, Chuo‐ku Kumamoto 860‐8556 JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University 1‐1‐1, Honjo, Chuo‐ku Kumamoto 860‐8556 JapanDiagnostic Radiology, Graduate School of Medical Sciences Kumamoto University Kumamoto JapanBreast and Endocrine Surgery, Graduate School of Medical Sciences Kumamoto University Kumamoto JapanDiagnostic Radiology, Graduate School of Medical Sciences Kumamoto University Kumamoto JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University 1‐1‐1, Honjo, Chuo‐ku Kumamoto 860‐8556 JapanBreast and Endocrine Surgery, Graduate School of Medical Sciences Kumamoto University Kumamoto JapanBreast and Endocrine Surgery, Graduate School of Medical Sciences Kumamoto University Kumamoto JapanBreast and Endocrine Surgery, Graduate School of Medical Sciences Kumamoto University Kumamoto JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University 1‐1‐1, Honjo, Chuo‐ku Kumamoto 860‐8556 JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University 1‐1‐1, Honjo, Chuo‐ku Kumamoto 860‐8556 JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University 1‐1‐1, Honjo, Chuo‐ku Kumamoto 860‐8556 JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University 1‐1‐1, Honjo, Chuo‐ku Kumamoto 860‐8556 JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University 1‐1‐1, Honjo, Chuo‐ku Kumamoto 860‐8556 JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University 1‐1‐1, Honjo, Chuo‐ku Kumamoto 860‐8556 JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University 1‐1‐1, Honjo, Chuo‐ku Kumamoto 860‐8556 JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University 1‐1‐1, Honjo, Chuo‐ku Kumamoto 860‐8556 JapanBreast and Endocrine Surgery, Graduate School of Medical Sciences Kumamoto University Kumamoto JapanDiagnostic Radiology, Graduate School of Medical Sciences Kumamoto University Kumamoto JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University 1‐1‐1, Honjo, Chuo‐ku Kumamoto 860‐8556 JapanAbstract Aims Understanding cardiac function after anthracycline administration is very important from the perspective of preventing the onset of heart failure. Although cardiac magnetic resonance and echocardiography are recognized as the ‘gold standard’ for detecting cardiotoxicity, they have many shortcomings. We aimed to investigate whether cardiac computed tomography (CCT) could replace these techniques, assessing serial changes in cardiac tissue characteristics as determined by CCT after anthracycline administration. Methods and results We prospectively investigated 15 consecutive breast cancer patients who were scheduled to receive anthracycline therapy. We performed echocardiography and CCT before and 3, 6, and 12 months after anthracycline treatment. The mean cumulative administered anthracycline dose was 269.9 ± 14.6 mg/m2 (doxorubicin‐converted dose). Of the 15 enrolled patients who received anthracycline treatment for breast cancer, none met the definition of cardiotoxicity. The CCT‐derived extracellular volume fraction tended to continue to increase after anthracycline treatment and had relatively similar dynamics to the left ventricular ejection fraction and global longitudinal strain as determined by echocardiography. Conclusions Our findings indicated that CCT could provide adequate information about the characteristics of myocardial tissue after anthracycline administration. CCT may improve the understanding of cardiotoxicity by compensating for the weaknesses of echocardiography. This technique could be useful for understanding cardiac tissue characterization as a ‘one‐stop shop’ evaluation, providing new insight into cardiooncology.https://doi.org/10.1002/ehf2.13867CardiooncologyCardiotoxicityAnthracyclineCardiac computed tomography |
| spellingShingle | Koichi Egashira Daisuke Sueta Masafumi Kidoh Mai Tomiguchi Seitaro Oda Hiroki Usuku Kaori Hidaka Lisa Goto‐Yamaguchi Aiko Sueta Takashi Komorita Fumi Oike Koichiro Fujisue Eiichiro Yamamoto Shinsuke Hanatani Seiji Takashio Satoshi Araki Kenichi Matsushita Yutaka Yamamoto Toshinori Hirai Kenichi Tsujita Cardiac computed tomography‐derived myocardial tissue characterization after anthracycline treatment ESC Heart Failure Cardiooncology Cardiotoxicity Anthracycline Cardiac computed tomography |
| title | Cardiac computed tomography‐derived myocardial tissue characterization after anthracycline treatment |
| title_full | Cardiac computed tomography‐derived myocardial tissue characterization after anthracycline treatment |
| title_fullStr | Cardiac computed tomography‐derived myocardial tissue characterization after anthracycline treatment |
| title_full_unstemmed | Cardiac computed tomography‐derived myocardial tissue characterization after anthracycline treatment |
| title_short | Cardiac computed tomography‐derived myocardial tissue characterization after anthracycline treatment |
| title_sort | cardiac computed tomography derived myocardial tissue characterization after anthracycline treatment |
| topic | Cardiooncology Cardiotoxicity Anthracycline Cardiac computed tomography |
| url | https://doi.org/10.1002/ehf2.13867 |
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