FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury
Traumatic brain injury (TBI) can lead to physical and cognitive deficits, which are caused by the secondary injury process. Effective pharmacotherapies for TBI patients are still lacking. Fibroblast growth factor-2 (FGF2) is an important neurotrophic factor that can stimulate neurogenesis and angiog...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/2923182 |
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| author | Chonghui Tang Yudong Shan Yilan Hu Zhanjian Fang Yun Tong Mengdan Chen Xiaojie Wei Xiaojun Fu Xinlong Xu |
| author_facet | Chonghui Tang Yudong Shan Yilan Hu Zhanjian Fang Yun Tong Mengdan Chen Xiaojie Wei Xiaojun Fu Xinlong Xu |
| author_sort | Chonghui Tang |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) can lead to physical and cognitive deficits, which are caused by the secondary injury process. Effective pharmacotherapies for TBI patients are still lacking. Fibroblast growth factor-2 (FGF2) is an important neurotrophic factor that can stimulate neurogenesis and angiogenesis and has been shown to have neuroprotective effects after brain insults. Previous studies indicated that FGF2’s neuroprotective effects might be related to its function of regulating autophagy. The present study investigated FGF2’s beneficial effects in the early stage of rat mild TBI and the underlying mechanisms. One hundred and forty-four rats were used for creating controlled cortical impact (CCI) models to simulate the pathological damage after TBI. Our results indicated that pretreatment of FGF2 played a neuroprotective role in the early stage of rat mild TBI through alleviating brain edema, reducing neurological deficits, preventing tissue loss, and increasing the number of surviving neurons in injured cortex and the ipsilateral hippocampus. FGF2 could also protect cells from various forms of death such as apoptosis or necrosis through inhibition of autophagy. Finally, autophagy activator rapamycin could abolish the protective effects of FGF2. This study extended our understanding of FGF2’s neuroprotective effects and shed lights on the pharmacological therapy after TBI. |
| format | Article |
| id | doaj-art-f36048250f5e40638e6f5e455316f156 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f36048250f5e40638e6f5e455316f1562025-02-03T01:24:25ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/29231822923182FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain InjuryChonghui Tang0Yudong Shan1Yilan Hu2Zhanjian Fang3Yun Tong4Mengdan Chen5Xiaojie Wei6Xiaojun Fu7Xinlong Xu8Department of Neurosurgery, Affiliated Cixi Hospital, Wenzhou Medical University, No. 999 Nanerhuandong Road, Ningbo 315300, ChinaDepartment of Neurosurgery, Affiliated Cixi Hospital, Wenzhou Medical University, No. 999 Nanerhuandong Road, Ningbo 315300, ChinaDepartment of Neurosurgery, Affiliated Cixi Hospital, Wenzhou Medical University, No. 999 Nanerhuandong Road, Ningbo 315300, ChinaDepartment of Neurosurgery, Affiliated Cixi Hospital, Wenzhou Medical University, No. 999 Nanerhuandong Road, Ningbo 315300, ChinaDepartment of Neurosurgery, Affiliated Cixi Hospital, Wenzhou Medical University, No. 999 Nanerhuandong Road, Ningbo 315300, ChinaDepartment of Neurosurgery, Affiliated Cixi Hospital, Wenzhou Medical University, No. 999 Nanerhuandong Road, Ningbo 315300, ChinaDepartment of Neurosurgery, Affiliated Cixi Hospital, Wenzhou Medical University, No. 999 Nanerhuandong Road, Ningbo 315300, ChinaDepartment of Neurosurgery, Affiliated Cixi Hospital, Wenzhou Medical University, No. 999 Nanerhuandong Road, Ningbo 315300, ChinaDepartment of Neurosurgery, Affiliated Cixi Hospital, Wenzhou Medical University, No. 999 Nanerhuandong Road, Ningbo 315300, ChinaTraumatic brain injury (TBI) can lead to physical and cognitive deficits, which are caused by the secondary injury process. Effective pharmacotherapies for TBI patients are still lacking. Fibroblast growth factor-2 (FGF2) is an important neurotrophic factor that can stimulate neurogenesis and angiogenesis and has been shown to have neuroprotective effects after brain insults. Previous studies indicated that FGF2’s neuroprotective effects might be related to its function of regulating autophagy. The present study investigated FGF2’s beneficial effects in the early stage of rat mild TBI and the underlying mechanisms. One hundred and forty-four rats were used for creating controlled cortical impact (CCI) models to simulate the pathological damage after TBI. Our results indicated that pretreatment of FGF2 played a neuroprotective role in the early stage of rat mild TBI through alleviating brain edema, reducing neurological deficits, preventing tissue loss, and increasing the number of surviving neurons in injured cortex and the ipsilateral hippocampus. FGF2 could also protect cells from various forms of death such as apoptosis or necrosis through inhibition of autophagy. Finally, autophagy activator rapamycin could abolish the protective effects of FGF2. This study extended our understanding of FGF2’s neuroprotective effects and shed lights on the pharmacological therapy after TBI.http://dx.doi.org/10.1155/2017/2923182 |
| spellingShingle | Chonghui Tang Yudong Shan Yilan Hu Zhanjian Fang Yun Tong Mengdan Chen Xiaojie Wei Xiaojun Fu Xinlong Xu FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury Stem Cells International |
| title | FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury |
| title_full | FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury |
| title_fullStr | FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury |
| title_full_unstemmed | FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury |
| title_short | FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury |
| title_sort | fgf2 attenuates neural cell death via suppressing autophagy after rat mild traumatic brain injury |
| url | http://dx.doi.org/10.1155/2017/2923182 |
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