Essential lipids enrich membrane-associated condensates to rescue synaptic morpho-functional deficits in a mouse model of autism

Summary: Synaptic proteins form intracellular condensates with their scaffolds, but it is unknown whether and how essential lipids transform dynamic cytosolic condensates into stable, functional macromolecular assemblies at the membrane. We show that docosahexaenoic acid (DHA), independent of canoni...

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Main Authors: Jason Arsenault, Tian Kong, Rayan Saghian, Octavia Yifang Weng, Salil Saurav Pathak, Chengye Yang, Owen Y. Chao, Gaddy Rakhaminov, Julie D. Forman-Kay, Jonathon A. Ditlev, Yi-Mei Yang, Lu-Yang Wang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003444
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