Innovative Drug Modalities for the Treatment of Advanced Prostate Cancer
Prostate cancer, a prevalent malignancy affecting the prostate gland, is a significant global health concern. Androgen-deprivation therapy (ADT) has proven effective in controlling advanced disease, with over 50% of patients surviving at the 10-year mark. However, a diverse spectrum of responses exi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-05-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/12/5/87 |
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| author | Maurizio Capuozzo Mariachiara Santorsola Monica Ianniello Francesco Ferrara Andrea Zovi Nadia Petrillo Rosa Castiello Maria Rosaria Fantuz Alessandro Ottaiano Giovanni Savarese |
| author_facet | Maurizio Capuozzo Mariachiara Santorsola Monica Ianniello Francesco Ferrara Andrea Zovi Nadia Petrillo Rosa Castiello Maria Rosaria Fantuz Alessandro Ottaiano Giovanni Savarese |
| author_sort | Maurizio Capuozzo |
| collection | DOAJ |
| description | Prostate cancer, a prevalent malignancy affecting the prostate gland, is a significant global health concern. Androgen-deprivation therapy (ADT) has proven effective in controlling advanced disease, with over 50% of patients surviving at the 10-year mark. However, a diverse spectrum of responses exists, and resistance to ADT may emerge over time. This underscores the need to explore innovative treatment strategies for effectively managing prostate cancer progression. Ongoing research endeavors persist in unraveling the complexity of prostate cancer and fostering the development of biologic and innovative approaches, including immunotherapies and targeted therapies. This review aims to provide a valuable synthesis of the dynamic landscape of emerging drug modalities in this context. Interestingly, the complexities posed by prostate cancer not only present a formidable challenge but also serve as a model and an opportunity for translational research and innovative therapies in the field of oncology. |
| format | Article |
| id | doaj-art-f34831f525c04fc2b6b6161926494fb3 |
| institution | Kabale University |
| issn | 2079-9721 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj-art-f34831f525c04fc2b6b6161926494fb32025-01-22T15:48:46ZengMDPI AGDiseases2079-97212024-05-011258710.3390/diseases12050087Innovative Drug Modalities for the Treatment of Advanced Prostate CancerMaurizio Capuozzo0Mariachiara Santorsola1Monica Ianniello2Francesco Ferrara3Andrea Zovi4Nadia Petrillo5Rosa Castiello6Maria Rosaria Fantuz7Alessandro Ottaiano8Giovanni Savarese9Coordinamento Farmaceutico, ASL-Naples-3, 80056 Ercolano, ItalyIstituto Nazionale Tumori di Napoli, IRCCS “G. Pascale”, Via M. Semmola, 80131 Naples, ItalyAMES, Centro Polidiagnostico Strumentale srl, Via Padre Carmine Fico 24, 80013 Casalnuovo Di Napoli, ItalyCoordinamento Farmaceutico, ASL-Naples-3, 80056 Ercolano, ItalyMinistry of Health, Viale Giorgio Ribotta 5, 00144 Rome, ItalyAMES, Centro Polidiagnostico Strumentale srl, Via Padre Carmine Fico 24, 80013 Casalnuovo Di Napoli, ItalyAMES, Centro Polidiagnostico Strumentale srl, Via Padre Carmine Fico 24, 80013 Casalnuovo Di Napoli, ItalyAMES, Centro Polidiagnostico Strumentale srl, Via Padre Carmine Fico 24, 80013 Casalnuovo Di Napoli, ItalyIstituto Nazionale Tumori di Napoli, IRCCS “G. Pascale”, Via M. Semmola, 80131 Naples, ItalyAMES, Centro Polidiagnostico Strumentale srl, Via Padre Carmine Fico 24, 80013 Casalnuovo Di Napoli, ItalyProstate cancer, a prevalent malignancy affecting the prostate gland, is a significant global health concern. Androgen-deprivation therapy (ADT) has proven effective in controlling advanced disease, with over 50% of patients surviving at the 10-year mark. However, a diverse spectrum of responses exists, and resistance to ADT may emerge over time. This underscores the need to explore innovative treatment strategies for effectively managing prostate cancer progression. Ongoing research endeavors persist in unraveling the complexity of prostate cancer and fostering the development of biologic and innovative approaches, including immunotherapies and targeted therapies. This review aims to provide a valuable synthesis of the dynamic landscape of emerging drug modalities in this context. Interestingly, the complexities posed by prostate cancer not only present a formidable challenge but also serve as a model and an opportunity for translational research and innovative therapies in the field of oncology.https://www.mdpi.com/2079-9721/12/5/87prostate cancerandrogen-deprivation therapyimmunotherapyPARP inhibitorsprecision medicine |
| spellingShingle | Maurizio Capuozzo Mariachiara Santorsola Monica Ianniello Francesco Ferrara Andrea Zovi Nadia Petrillo Rosa Castiello Maria Rosaria Fantuz Alessandro Ottaiano Giovanni Savarese Innovative Drug Modalities for the Treatment of Advanced Prostate Cancer Diseases prostate cancer androgen-deprivation therapy immunotherapy PARP inhibitors precision medicine |
| title | Innovative Drug Modalities for the Treatment of Advanced Prostate Cancer |
| title_full | Innovative Drug Modalities for the Treatment of Advanced Prostate Cancer |
| title_fullStr | Innovative Drug Modalities for the Treatment of Advanced Prostate Cancer |
| title_full_unstemmed | Innovative Drug Modalities for the Treatment of Advanced Prostate Cancer |
| title_short | Innovative Drug Modalities for the Treatment of Advanced Prostate Cancer |
| title_sort | innovative drug modalities for the treatment of advanced prostate cancer |
| topic | prostate cancer androgen-deprivation therapy immunotherapy PARP inhibitors precision medicine |
| url | https://www.mdpi.com/2079-9721/12/5/87 |
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