The Impact of Infectious Diseases on Clinical Characteristics and Immunological Correlations in Pediatric Henoch–Schönlein Purpura: A Five-Year Retrospective Study
<b>Background/Objectives:</b> Immunoglobulin A (IgA) vasculitis (IgAV), classically known as Henoch–Schönlein purpura (HSP), is a type of nonthrombocytopenic small-vessel vasculitis. HSP is the most frequent kind of systemic vasculitis in children, characterized by purpura, arthritis or...
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2025-01-01
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| author | Sînziana Oprițescu Gabriela Viorela Nițescu Mihaela Golumbeanu Dora Boghițoiu Elena Iuliana Ioniță Diana-Andreea Ușurelu Cristian Lucaci Adriana Negoiță Elena Moroșan |
| author_facet | Sînziana Oprițescu Gabriela Viorela Nițescu Mihaela Golumbeanu Dora Boghițoiu Elena Iuliana Ioniță Diana-Andreea Ușurelu Cristian Lucaci Adriana Negoiță Elena Moroșan |
| author_sort | Sînziana Oprițescu |
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| description | <b>Background/Objectives:</b> Immunoglobulin A (IgA) vasculitis (IgAV), classically known as Henoch–Schönlein purpura (HSP), is a type of nonthrombocytopenic small-vessel vasculitis. HSP is the most frequent kind of systemic vasculitis in children, characterized by purpura, arthritis or arthralgia, gastrointestinal pain, and kidney dysfunction. The aim of our research was to investigate and observe the clinical characteristics of children diagnosed with HSP and to explore the correlation between infectious diseases and HSP. Furthermore, this retrospective study considered other factors, such as demographic characteristics (sex, area/environment, and age), and their effect on the pediatric population diagnosed with HSP. <b>Methods:</b> To answer this question, we conducted a five-year hospital-based retrospective study that included 144 hospitalized children who were diagnosed with HSP during hospitalization. Measurements of immunological panels (IgA, IgM, IgG, and IgE), C3, C4, C-reactive protein, fibrinogen, and hematite sedimentation rate (VSH) determined using blood samples revealed that there is a strong correlation between the elements of the immunological panel and the HSP manifestations. <b>Results:</b> Additionally, elevated IgG and normal IgA serum levels in pediatric HSP patients are strongly associated with infectious diseases. <b>Conclusions</b>: Notably, patients with infectious diseases exhibited high IgG and normal IgA serum levels post-treatment and a higher risk of relapses. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| series | Biomedicines |
| spelling | doaj-art-f3452bc26f354e62ac470014dd0e94a82025-01-24T13:24:03ZengMDPI AGBiomedicines2227-90592025-01-0113111310.3390/biomedicines13010113The Impact of Infectious Diseases on Clinical Characteristics and Immunological Correlations in Pediatric Henoch–Schönlein Purpura: A Five-Year Retrospective StudySînziana Oprițescu0Gabriela Viorela Nițescu1Mihaela Golumbeanu2Dora Boghițoiu3Elena Iuliana Ioniță4Diana-Andreea Ușurelu5Cristian Lucaci6Adriana Negoiță7Elena Moroșan8Discipline of Clinical Laboratory and Food Safety, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, RomaniaDiscipline of Pediatrics, Faculty of Dentistry, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania“Grigore Alexandrescu” Clinical Emergency Hospital for Children, 017443 Bucharest, RomaniaDiscipline of Pediatrics, Faculty of Dentistry, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDiscipline of Pharmacognosy, Phytochemistry and Phytotherapy, Faculty of Pharmacy, “Carol Davila”, University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, RomaniaDiscipline of Pediatrics, Faculty of Dentistry, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDiscipline of Pediatrics, Faculty of Dentistry, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDiscipline of Pediatrics, Faculty of Dentistry, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDiscipline of Clinical Laboratory and Food Safety, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania<b>Background/Objectives:</b> Immunoglobulin A (IgA) vasculitis (IgAV), classically known as Henoch–Schönlein purpura (HSP), is a type of nonthrombocytopenic small-vessel vasculitis. HSP is the most frequent kind of systemic vasculitis in children, characterized by purpura, arthritis or arthralgia, gastrointestinal pain, and kidney dysfunction. The aim of our research was to investigate and observe the clinical characteristics of children diagnosed with HSP and to explore the correlation between infectious diseases and HSP. Furthermore, this retrospective study considered other factors, such as demographic characteristics (sex, area/environment, and age), and their effect on the pediatric population diagnosed with HSP. <b>Methods:</b> To answer this question, we conducted a five-year hospital-based retrospective study that included 144 hospitalized children who were diagnosed with HSP during hospitalization. Measurements of immunological panels (IgA, IgM, IgG, and IgE), C3, C4, C-reactive protein, fibrinogen, and hematite sedimentation rate (VSH) determined using blood samples revealed that there is a strong correlation between the elements of the immunological panel and the HSP manifestations. <b>Results:</b> Additionally, elevated IgG and normal IgA serum levels in pediatric HSP patients are strongly associated with infectious diseases. <b>Conclusions</b>: Notably, patients with infectious diseases exhibited high IgG and normal IgA serum levels post-treatment and a higher risk of relapses.https://www.mdpi.com/2227-9059/13/1/113Henoch–Schönlein purpuraIgA vasculitisallergic vasculitisinfectious diseases |
| spellingShingle | Sînziana Oprițescu Gabriela Viorela Nițescu Mihaela Golumbeanu Dora Boghițoiu Elena Iuliana Ioniță Diana-Andreea Ușurelu Cristian Lucaci Adriana Negoiță Elena Moroșan The Impact of Infectious Diseases on Clinical Characteristics and Immunological Correlations in Pediatric Henoch–Schönlein Purpura: A Five-Year Retrospective Study Biomedicines Henoch–Schönlein purpura IgA vasculitis allergic vasculitis infectious diseases |
| title | The Impact of Infectious Diseases on Clinical Characteristics and Immunological Correlations in Pediatric Henoch–Schönlein Purpura: A Five-Year Retrospective Study |
| title_full | The Impact of Infectious Diseases on Clinical Characteristics and Immunological Correlations in Pediatric Henoch–Schönlein Purpura: A Five-Year Retrospective Study |
| title_fullStr | The Impact of Infectious Diseases on Clinical Characteristics and Immunological Correlations in Pediatric Henoch–Schönlein Purpura: A Five-Year Retrospective Study |
| title_full_unstemmed | The Impact of Infectious Diseases on Clinical Characteristics and Immunological Correlations in Pediatric Henoch–Schönlein Purpura: A Five-Year Retrospective Study |
| title_short | The Impact of Infectious Diseases on Clinical Characteristics and Immunological Correlations in Pediatric Henoch–Schönlein Purpura: A Five-Year Retrospective Study |
| title_sort | impact of infectious diseases on clinical characteristics and immunological correlations in pediatric henoch schonlein purpura a five year retrospective study |
| topic | Henoch–Schönlein purpura IgA vasculitis allergic vasculitis infectious diseases |
| url | https://www.mdpi.com/2227-9059/13/1/113 |
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