Pulmonary Complications of Azanucleoside Therapy in Patients with Myelodysplastic Syndrome and Acute Myelogenous Leukemia
Our primary aim was to identify potential risk factors and clinical outcome of azanucleoside induced pulmonary complications in patients with myelodysplastic syndrome (MDS) and Acute Myelogenous Leukemia (AML). We present an 89-year-old female with MDS derived AML who developed fatigability, hypoxem...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2015/357461 |
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| author | Manuel Molina Sarvari Yellapragada Martha Mims Effie Rahman Gustavo Rivero |
| author_facet | Manuel Molina Sarvari Yellapragada Martha Mims Effie Rahman Gustavo Rivero |
| author_sort | Manuel Molina |
| collection | DOAJ |
| description | Our primary aim was to identify potential risk factors and clinical outcome of azanucleoside induced pulmonary complications in patients with myelodysplastic syndrome (MDS) and Acute Myelogenous Leukemia (AML). We present an 89-year-old female with MDS derived AML who developed fatigability, hypoxemia, and bilateral lung infiltrates indicating interstitial lung disease after 11 cycles of azanucleoside. In addition, we describe a cohort of six MDS patients with fever, cough, dyspnea, and pulmonary infiltrates at early time point during azanucleoside treatment. Early and late onset of pulmonary manifestations suggest different pathogenic mechanisms. Brief azanucleoside discontinuation and steroids led to rapid improvement in symptoms. |
| format | Article |
| id | doaj-art-f3368ac74c0d4716a20809b25e6d5b3e |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-f3368ac74c0d4716a20809b25e6d5b3e2025-02-03T01:30:13ZengWileyCase Reports in Hematology2090-65602090-65792015-01-01201510.1155/2015/357461357461Pulmonary Complications of Azanucleoside Therapy in Patients with Myelodysplastic Syndrome and Acute Myelogenous LeukemiaManuel Molina0Sarvari Yellapragada1Martha Mims2Effie Rahman3Gustavo Rivero4St. Luke’s Episcopal Hospital, Houston, TX 77030, USABaylor College of Medicine, Section of Hematology and Oncology, 1 Baylor Plaza, Houston, TX 77030, USASt. Luke’s Episcopal Hospital, Houston, TX 77030, USABaylor College of Medicine, Section of Hematology and Oncology, 1 Baylor Plaza, Houston, TX 77030, USASt. Luke’s Episcopal Hospital, Houston, TX 77030, USAOur primary aim was to identify potential risk factors and clinical outcome of azanucleoside induced pulmonary complications in patients with myelodysplastic syndrome (MDS) and Acute Myelogenous Leukemia (AML). We present an 89-year-old female with MDS derived AML who developed fatigability, hypoxemia, and bilateral lung infiltrates indicating interstitial lung disease after 11 cycles of azanucleoside. In addition, we describe a cohort of six MDS patients with fever, cough, dyspnea, and pulmonary infiltrates at early time point during azanucleoside treatment. Early and late onset of pulmonary manifestations suggest different pathogenic mechanisms. Brief azanucleoside discontinuation and steroids led to rapid improvement in symptoms.http://dx.doi.org/10.1155/2015/357461 |
| spellingShingle | Manuel Molina Sarvari Yellapragada Martha Mims Effie Rahman Gustavo Rivero Pulmonary Complications of Azanucleoside Therapy in Patients with Myelodysplastic Syndrome and Acute Myelogenous Leukemia Case Reports in Hematology |
| title | Pulmonary Complications of Azanucleoside Therapy in Patients with Myelodysplastic Syndrome and Acute Myelogenous Leukemia |
| title_full | Pulmonary Complications of Azanucleoside Therapy in Patients with Myelodysplastic Syndrome and Acute Myelogenous Leukemia |
| title_fullStr | Pulmonary Complications of Azanucleoside Therapy in Patients with Myelodysplastic Syndrome and Acute Myelogenous Leukemia |
| title_full_unstemmed | Pulmonary Complications of Azanucleoside Therapy in Patients with Myelodysplastic Syndrome and Acute Myelogenous Leukemia |
| title_short | Pulmonary Complications of Azanucleoside Therapy in Patients with Myelodysplastic Syndrome and Acute Myelogenous Leukemia |
| title_sort | pulmonary complications of azanucleoside therapy in patients with myelodysplastic syndrome and acute myelogenous leukemia |
| url | http://dx.doi.org/10.1155/2015/357461 |
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