TLR4 Inhibition Attenuated LPS‐Induced Proinflammatory Signaling and Cytokine Release in Mouse Hearts and Cardiomyocytes

TLR4 Inhibition Attenuated LPS‐Induced Proinflammatory Signaling and Cytokine Release in Mouse Hearts and Cardiomyocytes

ABSTRACT Background Sepsis is associated with myocardial injury and early mortality. The innate immune receptor Toll‐like receptor 4 (TLR4) can recognize pathogen‐associated‐molecular‐patterns (PAMPs) and damage‐associated molecular patterns (DAMPs); the latter are released during tissue injury. We...

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Bibliographic Details
Main Authors: Christine W. Wiger, Trine Ranheim, Henriette Arnesen, Jarle Vaage, Søren E. Pischke, Arne Yndestad, Kåre‐Olav Stensløkken, May‐Kristin Torp
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Immunity, Inflammation and Disease
Subjects:
DAMPs
heart
inflammation
LPS
PAMPs
sepsis
Online Access:https://doi.org/10.1002/iid3.70133
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