In Vitro Determine the Cytotoxicity of Cerium Oxide Nanoparticles Against HBL-100 and Rat’s Embryonic Fibroblast (REF) Cell Lines
This work was conceived as a contribution to the study of the cytotoxicity of different concentrations of cerium oxide nanoparticles (CeO2NPs≥25nm, nanoceria) (10, 30, 60, 90, and 120 µg/ml) against two cell lines involves breast epithelial HBL-100 and Rat’s Embryonic...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
College of Veterinary Medicine, University of Basrah, Iraq
2025-03-01
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| Series: | Basrah Journal of Veterinary Research |
| Subjects: | |
| Online Access: | https://bjvr.uobasrah.edu.iq/article_186946_d2d01d769824a841f131a0d900d8609b.pdf |
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| Summary: | This work was conceived as a contribution to the study of the cytotoxicity of different concentrations of cerium oxide nanoparticles (CeO2NPs≥25nm, nanoceria) (10, 30, 60, 90, and 120 µg/ml) against two cell lines involves breast epithelial HBL-100 and Rat’s Embryonic Fibroblast (REF) in vitro, by using MTT assay technique. The results showed that the nanoceria reduced significantly the cell viability of HBL-100 at all concentrations compared with the control, except the concentration 60 µg/ml that reduced the cell viability without significant differences compared with control, the IC50 value of the nanoceria for the HBL-100 was 81.00 µg/mL. While, the cell viability of REF was reduced with high significant difference by all nanoceria’s concentrations compared with control, and the IC50 value of the nanoceria was 1.56 µg/mL. So, we may conclude that nanoceria with the >25nm particle size have high cytotoxicity for REF cell line at low and high concentration compared with the HBL-100 cell viability that decreased exponentially with the concentration. |
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| ISSN: | 1813-8497 2410-8456 |