Review of celiac disease in the pediatric population
Celiac disease (CD) is a chronic autoimmune disease triggered by the ingestion of gluten in genetically predisposed individuals, primarily those with HLA-DQ2 and HLA-DQ8 haplotypes. The global prevalence of CD ranges from 0.5% to 1%. Recent advances in diagnostic methods and raising awareness of thi...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57703 |
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| author | Aleksandra Strawińska Maria Wydro Magdalena Grotowska Martyna Łukasiewicz |
| author_facet | Aleksandra Strawińska Maria Wydro Magdalena Grotowska Martyna Łukasiewicz |
| author_sort | Aleksandra Strawińska |
| collection | DOAJ |
| description | Celiac disease (CD) is a chronic autoimmune disease triggered by the ingestion of gluten in genetically predisposed individuals, primarily those with HLA-DQ2 and HLA-DQ8 haplotypes. The global prevalence of CD ranges from 0.5% to 1%. Recent advances in diagnostic methods and raising awareness of this disorder have improved detection rates, but many cases remain undiagnosed due to the disease's multifaceted presentation. CD can manifest with a wide range of symptoms, including both gastrointestinal and extraintestinal signs. In smaller children common symptoms include mainly chronic or intermittent abdominal pain, abdominal distension, diarrhea and constipation. Older children and adolescent patients may frequently present atypical, vague symptoms such as fatigue, failure to thrive, weight loss, short stature, behavioral changes and anemia. Diagnosis involves primarily serological tests in patients presenting symptoms or in patients with high-risk of developing CD. A strict gluten-free diet is the principal treatment and it is highly effective in managing symptoms and promoting intestinal healing. In this paper, we will analyze epidemiology of CD, its pathogenesis, heterogeneous clinical presentation, the diagnostic process and treatment based on recent guidelines and literature.
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| format | Article |
| id | doaj-art-f324b334b776470dae3512147ce8734c |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-f324b334b776470dae3512147ce8734c2025-01-28T08:25:05ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2025.37.57703Review of celiac disease in the pediatric populationAleksandra Strawińska0https://orcid.org/0009-0009-6100-9766Maria Wydro1https://orcid.org/0009-0009-6397-0737Magdalena Grotowska2https://orcid.org/0009-0002-2812-7639Martyna Łukasiewicz3https://orcid.org/0000-0002-8816-1030Mikołaj Kopernik Hospital in Gdańsk, PolandSzpital św. Wincentego a Paulo ul. Wójta Radtkego 1, 83-348 Gdynia, PolandMikołaj Kopernik Hospital in Gdańsk ul. Nowe Ogrody 1-6, 80 - 803 Gdańsk, Poland University Clinical Centre in Gdańsk ul. Smoluchowskiego 17, Gdańsk, PolandCeliac disease (CD) is a chronic autoimmune disease triggered by the ingestion of gluten in genetically predisposed individuals, primarily those with HLA-DQ2 and HLA-DQ8 haplotypes. The global prevalence of CD ranges from 0.5% to 1%. Recent advances in diagnostic methods and raising awareness of this disorder have improved detection rates, but many cases remain undiagnosed due to the disease's multifaceted presentation. CD can manifest with a wide range of symptoms, including both gastrointestinal and extraintestinal signs. In smaller children common symptoms include mainly chronic or intermittent abdominal pain, abdominal distension, diarrhea and constipation. Older children and adolescent patients may frequently present atypical, vague symptoms such as fatigue, failure to thrive, weight loss, short stature, behavioral changes and anemia. Diagnosis involves primarily serological tests in patients presenting symptoms or in patients with high-risk of developing CD. A strict gluten-free diet is the principal treatment and it is highly effective in managing symptoms and promoting intestinal healing. In this paper, we will analyze epidemiology of CD, its pathogenesis, heterogeneous clinical presentation, the diagnostic process and treatment based on recent guidelines and literature. https://apcz.umk.pl/QS/article/view/57703celiac diseaseceliac disease guidelinesdiagnosis of celiac diseasegluten-free diet |
| spellingShingle | Aleksandra Strawińska Maria Wydro Magdalena Grotowska Martyna Łukasiewicz Review of celiac disease in the pediatric population Quality in Sport celiac disease celiac disease guidelines diagnosis of celiac disease gluten-free diet |
| title | Review of celiac disease in the pediatric population |
| title_full | Review of celiac disease in the pediatric population |
| title_fullStr | Review of celiac disease in the pediatric population |
| title_full_unstemmed | Review of celiac disease in the pediatric population |
| title_short | Review of celiac disease in the pediatric population |
| title_sort | review of celiac disease in the pediatric population |
| topic | celiac disease celiac disease guidelines diagnosis of celiac disease gluten-free diet |
| url | https://apcz.umk.pl/QS/article/view/57703 |
| work_keys_str_mv | AT aleksandrastrawinska reviewofceliacdiseaseinthepediatricpopulation AT mariawydro reviewofceliacdiseaseinthepediatricpopulation AT magdalenagrotowska reviewofceliacdiseaseinthepediatricpopulation AT martynałukasiewicz reviewofceliacdiseaseinthepediatricpopulation |