Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review
Cholestyramine is a bile acid sequestrant that has been used in the treatment of hypercholesterolemia, pruritus due to elevated bile acid levels, and diarrhea due to bile acid malabsorption. This medication can rarely cause hyperchloremic nonanion gap metabolic acidosis, a complication featured in t...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2015/309791 |
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| _version_ | 1832564160319193088 |
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| author | Fareed B. Kamar Rory F. McQuillan |
| author_facet | Fareed B. Kamar Rory F. McQuillan |
| author_sort | Fareed B. Kamar |
| collection | DOAJ |
| description | Cholestyramine is a bile acid sequestrant that has been used in the treatment of hypercholesterolemia, pruritus due to elevated bile acid levels, and diarrhea due to bile acid malabsorption. This medication can rarely cause hyperchloremic nonanion gap metabolic acidosis, a complication featured in this report of an adult male with concomitant acute kidney injury. This case emphasizes the caution that must be taken in prescribing cholestyramine to patients who may also be volume depleted, in renal failure, or taking spironolactone. |
| format | Article |
| id | doaj-art-f321e0dd24fe48728dd8fe676ec0b934 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-f321e0dd24fe48728dd8fe676ec0b9342025-02-03T01:11:40ZengWileyCase Reports in Nephrology2090-66412090-665X2015-01-01201510.1155/2015/309791309791Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature ReviewFareed B. Kamar0Rory F. McQuillan1University of Calgary, Suite G15, 1403-29 Street NW, Calgary, AB, T2N 2T9, CanadaUniversity of Toronto and University Health Network, Toronto General Hospital, Room 8N-842, 200 Elizabeth Street, Toronto, ON, M5G 2C4, CanadaCholestyramine is a bile acid sequestrant that has been used in the treatment of hypercholesterolemia, pruritus due to elevated bile acid levels, and diarrhea due to bile acid malabsorption. This medication can rarely cause hyperchloremic nonanion gap metabolic acidosis, a complication featured in this report of an adult male with concomitant acute kidney injury. This case emphasizes the caution that must be taken in prescribing cholestyramine to patients who may also be volume depleted, in renal failure, or taking spironolactone.http://dx.doi.org/10.1155/2015/309791 |
| spellingShingle | Fareed B. Kamar Rory F. McQuillan Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review Case Reports in Nephrology |
| title | Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review |
| title_full | Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review |
| title_fullStr | Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review |
| title_full_unstemmed | Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review |
| title_short | Hyperchloremic Metabolic Acidosis due to Cholestyramine: A Case Report and Literature Review |
| title_sort | hyperchloremic metabolic acidosis due to cholestyramine a case report and literature review |
| url | http://dx.doi.org/10.1155/2015/309791 |
| work_keys_str_mv | AT fareedbkamar hyperchloremicmetabolicacidosisduetocholestyramineacasereportandliteraturereview AT roryfmcquillan hyperchloremicmetabolicacidosisduetocholestyramineacasereportandliteraturereview |