Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy
ObjectiveThe most prevalent types of dementia in older adults are Alzheimer's disease (AD) and Lewy body dementia (LBD), and they have overlapping clinical symptoms. We aimed to define amounts of cortical activation and to identify indicators of brain function to better distinguish between thes...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1488420/full |
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| author | Nairong Ruan Nairong Ruan Ming Liang Ming Liang Yuehong Liu Xi Mei Chengying Zheng |
| author_facet | Nairong Ruan Nairong Ruan Ming Liang Ming Liang Yuehong Liu Xi Mei Chengying Zheng |
| author_sort | Nairong Ruan |
| collection | DOAJ |
| description | ObjectiveThe most prevalent types of dementia in older adults are Alzheimer's disease (AD) and Lewy body dementia (LBD), and they have overlapping clinical symptoms. We aimed to define amounts of cortical activation and to identify indicators of brain function to better distinguish between these types of dementia and aid diagnosis using functional near-infrared spectroscopy (fNIRS).MethodsOxygenated hemoglobin (HbO) concentrations in the brains of patients with AD and LBD were detected using fNIRS. Brain function was assessed using a verbal fluency task (VFT). Resting-state and task-state cortical activations were investigated to determine differences between AD and LBD. Blood samples were analyzed to identify relevant biomarkers. The clinical and HbO variables were compared between AD and LBD. Functional connectivity at rest and correlations between HbO variables and blood biomarkers were analyzed. The sensitivity and specificity of the parameters for differentiating the dementias were evaluated using areas under the receiver operating characteristic (ROC) curves (AUCs).ResultsThis study recruited 28 inpatients with AD and 25 with LBD. Mean HbO concentrations did not significantly differ in the resting state (p > 0.05), whereas functional connectivity significantly differed (t = −3.449, p = 0.001) between the groups. Mean HbO concentrations during the VFT, were significantly lower in the left temporal (p = 0.031), right dorsolateral prefrontal (p = 0.001), and right temporal (p = 0.011) cortices of the AD, than the LBD group. Blood amyloid-β (Aβ)42 levels were significantly higher in the AD group (p = 0.023), whereas significantly more α-synuclein was expressed in the LBD group (p = 0.012). Correlation analysis of cognition-related blood biomarkers with HbO concentrations associated higher plasma Aβ42 level with lower HbO concentrations in the right pre-motor and supplementary motor cortex (r = −0.378; p = 0.005) and higher glial fibrillary acidic protein (GFAP) levels in the lower right pars triangularis (r = −0.378; p = 0.006) at rest. Levels of the blood biomarker Aβ significantly and negatively correlated with HbO concentrations in the right temporal cortex (r = −0.329, p = 0.016) during the VFT. The AUC was significantly higher for the combination of multiple fNIRS indicators compared with individual cognitive or blood indicators (AUC = 0.9314).ConclusionThe characteristics of HbO measured using fNIRS can help distinguish AD from LBD in older adults. |
| format | Article |
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| institution | DOAJ |
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| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-f321aadcd2fa4554b9e10cbcc6b79a2a2025-08-20T03:06:43ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-04-011610.3389/fneur.2025.14884201488420Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopyNairong Ruan0Nairong Ruan1Ming Liang2Ming Liang3Yuehong Liu4Xi Mei5Chengying Zheng6Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Psychiatry, Ningbo Psychiatric Hospital, Ningbo, Zhejiang, ChinaDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Psychiatry, The Third People's Hospital of Xiangshan County, Ningbo, Zhejiang, ChinaDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, ChinaObjectiveThe most prevalent types of dementia in older adults are Alzheimer's disease (AD) and Lewy body dementia (LBD), and they have overlapping clinical symptoms. We aimed to define amounts of cortical activation and to identify indicators of brain function to better distinguish between these types of dementia and aid diagnosis using functional near-infrared spectroscopy (fNIRS).MethodsOxygenated hemoglobin (HbO) concentrations in the brains of patients with AD and LBD were detected using fNIRS. Brain function was assessed using a verbal fluency task (VFT). Resting-state and task-state cortical activations were investigated to determine differences between AD and LBD. Blood samples were analyzed to identify relevant biomarkers. The clinical and HbO variables were compared between AD and LBD. Functional connectivity at rest and correlations between HbO variables and blood biomarkers were analyzed. The sensitivity and specificity of the parameters for differentiating the dementias were evaluated using areas under the receiver operating characteristic (ROC) curves (AUCs).ResultsThis study recruited 28 inpatients with AD and 25 with LBD. Mean HbO concentrations did not significantly differ in the resting state (p > 0.05), whereas functional connectivity significantly differed (t = −3.449, p = 0.001) between the groups. Mean HbO concentrations during the VFT, were significantly lower in the left temporal (p = 0.031), right dorsolateral prefrontal (p = 0.001), and right temporal (p = 0.011) cortices of the AD, than the LBD group. Blood amyloid-β (Aβ)42 levels were significantly higher in the AD group (p = 0.023), whereas significantly more α-synuclein was expressed in the LBD group (p = 0.012). Correlation analysis of cognition-related blood biomarkers with HbO concentrations associated higher plasma Aβ42 level with lower HbO concentrations in the right pre-motor and supplementary motor cortex (r = −0.378; p = 0.005) and higher glial fibrillary acidic protein (GFAP) levels in the lower right pars triangularis (r = −0.378; p = 0.006) at rest. Levels of the blood biomarker Aβ significantly and negatively correlated with HbO concentrations in the right temporal cortex (r = −0.329, p = 0.016) during the VFT. The AUC was significantly higher for the combination of multiple fNIRS indicators compared with individual cognitive or blood indicators (AUC = 0.9314).ConclusionThe characteristics of HbO measured using fNIRS can help distinguish AD from LBD in older adults.https://www.frontiersin.org/articles/10.3389/fneur.2025.1488420/fullcortical activationAlzheimer's diseaseLewy body dementiafunctional near-infraredbiomarker |
| spellingShingle | Nairong Ruan Nairong Ruan Ming Liang Ming Liang Yuehong Liu Xi Mei Chengying Zheng Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy Frontiers in Neurology cortical activation Alzheimer's disease Lewy body dementia functional near-infrared biomarker |
| title | Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy |
| title_full | Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy |
| title_fullStr | Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy |
| title_full_unstemmed | Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy |
| title_short | Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy |
| title_sort | relationships among cortical activation cognition and blood biomarkers in two types of dementia determined using functional near infrared spectroscopy |
| topic | cortical activation Alzheimer's disease Lewy body dementia functional near-infrared biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1488420/full |
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