Vitamin D Predicts All-Cause and Cardiac Mortality in Females with Suspected Acute Coronary Syndrome: A Comparison with Brain Natriuretic Peptide and High-Sensitivity C-Reactive Protein
Vitamin D may not only reflect disease but may also serve as a prognostic indicator. Our aim was to assess the gender-specific utility of vitamin D measured as 25-hydroxy-vitamin D [25(OH)D] to predict all-cause and cardiac death in patients with suspected acute coronary syndrome (ACS) and to compar...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/398034 |
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| author | Patrycja A. Naesgaard Ricardo A. León de la Fuente Stein Tore Nilsen Leik Woie Torbjoern Aarsland Harry Staines Dennis W. T. Nilsen |
| author_facet | Patrycja A. Naesgaard Ricardo A. León de la Fuente Stein Tore Nilsen Leik Woie Torbjoern Aarsland Harry Staines Dennis W. T. Nilsen |
| author_sort | Patrycja A. Naesgaard |
| collection | DOAJ |
| description | Vitamin D may not only reflect disease but may also serve as a prognostic indicator. Our aim was to assess the gender-specific utility of vitamin D measured as 25-hydroxy-vitamin D [25(OH)D] to predict all-cause and cardiac death in patients with suspected acute coronary syndrome (ACS) and to compare its prognostic utility to brain natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hsCRP). Blood samples were harvested on admission in 982 patients. Forty percent were women (65.9 ± 12.6 years). Mortality was evaluated in quartiles of 25(OH)D, BNP, and hsCRP, respectively, during a 5-year follow-up, applying univariate and multivariate analyses. One hundred and seventy-three patients died; 78 were women. In 92 patients (37 women), death was defined as cardiac. In women, the univariate hazard ratio (HR) for total death of 25(OH)D in Quartile (Q) 2 versus Q1, Q3 versus Q1, and Q4 versus Q1 was 0.55 (95% CI 0.33–0.93), 0.29 (95% CI 0.15–0.55), and 0.13 (95% CI 0.06–0.32), respectively. In females, it was an independent predictor of total and cardiac death, whereas BNP and hsCRP were less gender-specific. No gender differences in 25(OH)D were noted in a reference material. Accordingly, vitamin D independently predicts mortality in females with suspected ACS. |
| format | Article |
| id | doaj-art-f3201c5e1ce04a6c9043624e1a7e56e0 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-f3201c5e1ce04a6c9043624e1a7e56e02025-02-03T05:52:41ZengWileyCardiology Research and Practice2090-80162090-05972013-01-01201310.1155/2013/398034398034Vitamin D Predicts All-Cause and Cardiac Mortality in Females with Suspected Acute Coronary Syndrome: A Comparison with Brain Natriuretic Peptide and High-Sensitivity C-Reactive ProteinPatrycja A. Naesgaard0Ricardo A. León de la Fuente1Stein Tore Nilsen2Leik Woie3Torbjoern Aarsland4Harry Staines5Dennis W. T. Nilsen6Department of Cardiology, Stavanger University Hospital, 4068 Stavanger, NorwayDepartment of Cardiology, Stavanger University Hospital, 4068 Stavanger, NorwayDepartment of Research, Stavanger University Hospital, 4068 Stavanger, NorwayDepartment of Cardiology, Stavanger University Hospital, 4068 Stavanger, NorwayDepartment of Research, Stavanger University Hospital, 4068 Stavanger, NorwaySigma Statistical Services, Balmullo KY16 0BJ, UKDepartment of Cardiology, Stavanger University Hospital, 4068 Stavanger, NorwayVitamin D may not only reflect disease but may also serve as a prognostic indicator. Our aim was to assess the gender-specific utility of vitamin D measured as 25-hydroxy-vitamin D [25(OH)D] to predict all-cause and cardiac death in patients with suspected acute coronary syndrome (ACS) and to compare its prognostic utility to brain natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hsCRP). Blood samples were harvested on admission in 982 patients. Forty percent were women (65.9 ± 12.6 years). Mortality was evaluated in quartiles of 25(OH)D, BNP, and hsCRP, respectively, during a 5-year follow-up, applying univariate and multivariate analyses. One hundred and seventy-three patients died; 78 were women. In 92 patients (37 women), death was defined as cardiac. In women, the univariate hazard ratio (HR) for total death of 25(OH)D in Quartile (Q) 2 versus Q1, Q3 versus Q1, and Q4 versus Q1 was 0.55 (95% CI 0.33–0.93), 0.29 (95% CI 0.15–0.55), and 0.13 (95% CI 0.06–0.32), respectively. In females, it was an independent predictor of total and cardiac death, whereas BNP and hsCRP were less gender-specific. No gender differences in 25(OH)D were noted in a reference material. Accordingly, vitamin D independently predicts mortality in females with suspected ACS.http://dx.doi.org/10.1155/2013/398034 |
| spellingShingle | Patrycja A. Naesgaard Ricardo A. León de la Fuente Stein Tore Nilsen Leik Woie Torbjoern Aarsland Harry Staines Dennis W. T. Nilsen Vitamin D Predicts All-Cause and Cardiac Mortality in Females with Suspected Acute Coronary Syndrome: A Comparison with Brain Natriuretic Peptide and High-Sensitivity C-Reactive Protein Cardiology Research and Practice |
| title | Vitamin D Predicts All-Cause and Cardiac Mortality in Females with Suspected Acute Coronary Syndrome: A Comparison with Brain Natriuretic Peptide and High-Sensitivity C-Reactive Protein |
| title_full | Vitamin D Predicts All-Cause and Cardiac Mortality in Females with Suspected Acute Coronary Syndrome: A Comparison with Brain Natriuretic Peptide and High-Sensitivity C-Reactive Protein |
| title_fullStr | Vitamin D Predicts All-Cause and Cardiac Mortality in Females with Suspected Acute Coronary Syndrome: A Comparison with Brain Natriuretic Peptide and High-Sensitivity C-Reactive Protein |
| title_full_unstemmed | Vitamin D Predicts All-Cause and Cardiac Mortality in Females with Suspected Acute Coronary Syndrome: A Comparison with Brain Natriuretic Peptide and High-Sensitivity C-Reactive Protein |
| title_short | Vitamin D Predicts All-Cause and Cardiac Mortality in Females with Suspected Acute Coronary Syndrome: A Comparison with Brain Natriuretic Peptide and High-Sensitivity C-Reactive Protein |
| title_sort | vitamin d predicts all cause and cardiac mortality in females with suspected acute coronary syndrome a comparison with brain natriuretic peptide and high sensitivity c reactive protein |
| url | http://dx.doi.org/10.1155/2013/398034 |
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