Fatal Toxoplasma gondii Dissemination in a Heart Transplant Recipient: Description of a Case
A 45-year-old heart transplant recipient presented with fever, anorexia, asthenia, and lethargy. She had received heart transplantation only 5 weeks earlier for primary systemic amyloidosis with severe cardiac involvement. Serum sodium was low, and tacrolimus through level was high. Blood cultures a...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2012/524279 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562089421438976 |
|---|---|
| author | S. Mastrobuoni A. M. Dell'Aquila J. Herreros |
| author_facet | S. Mastrobuoni A. M. Dell'Aquila J. Herreros |
| author_sort | S. Mastrobuoni |
| collection | DOAJ |
| description | A 45-year-old heart transplant recipient presented with fever, anorexia, asthenia, and lethargy. She had received heart transplantation only 5 weeks earlier for primary systemic amyloidosis with severe cardiac involvement. Serum sodium was low, and tacrolimus through level was high. Blood cultures and serology tests for infection were negative, and atypical pneumonia was suspected. Despite broad antibiotic, antiviral, and antifungal treatment, the patient clinical condition rapidly deteriorated and she died within three days of admission. Postmortem examination revealed a disseminated Toxoplasma gondii infection as a result of donor (+)/recipient(−) mismatch for Toxoplasma serology. Although very rare, toxoplasmosis in heart transplant recipient should be suspect in case of neurological deficit and respiratory symptoms. Prophylaxis treatment is recommended in case of mismatch. |
| format | Article |
| id | doaj-art-f31733f4f26c447298ef46ccc2ec9203 |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-f31733f4f26c447298ef46ccc2ec92032025-02-03T01:23:31ZengWileyCase Reports in Transplantation2090-69432090-69512012-01-01201210.1155/2012/524279524279Fatal Toxoplasma gondii Dissemination in a Heart Transplant Recipient: Description of a CaseS. Mastrobuoni0A. M. Dell'Aquila1J. Herreros2Department of Cardiovascular Surgery, University Hospital of Navarre, Avenida Pio XII, 31008 Pamplona, SpainDepartment of Cardiovascular Surgery, University Hospital of Navarre, Avenida Pio XII, 31008 Pamplona, SpainDepartment of Cardiovascular Surgery, University Hospital of Navarre, Avenida Pio XII, 31008 Pamplona, SpainA 45-year-old heart transplant recipient presented with fever, anorexia, asthenia, and lethargy. She had received heart transplantation only 5 weeks earlier for primary systemic amyloidosis with severe cardiac involvement. Serum sodium was low, and tacrolimus through level was high. Blood cultures and serology tests for infection were negative, and atypical pneumonia was suspected. Despite broad antibiotic, antiviral, and antifungal treatment, the patient clinical condition rapidly deteriorated and she died within three days of admission. Postmortem examination revealed a disseminated Toxoplasma gondii infection as a result of donor (+)/recipient(−) mismatch for Toxoplasma serology. Although very rare, toxoplasmosis in heart transplant recipient should be suspect in case of neurological deficit and respiratory symptoms. Prophylaxis treatment is recommended in case of mismatch.http://dx.doi.org/10.1155/2012/524279 |
| spellingShingle | S. Mastrobuoni A. M. Dell'Aquila J. Herreros Fatal Toxoplasma gondii Dissemination in a Heart Transplant Recipient: Description of a Case Case Reports in Transplantation |
| title | Fatal Toxoplasma gondii Dissemination in a Heart Transplant Recipient: Description of a Case |
| title_full | Fatal Toxoplasma gondii Dissemination in a Heart Transplant Recipient: Description of a Case |
| title_fullStr | Fatal Toxoplasma gondii Dissemination in a Heart Transplant Recipient: Description of a Case |
| title_full_unstemmed | Fatal Toxoplasma gondii Dissemination in a Heart Transplant Recipient: Description of a Case |
| title_short | Fatal Toxoplasma gondii Dissemination in a Heart Transplant Recipient: Description of a Case |
| title_sort | fatal toxoplasma gondii dissemination in a heart transplant recipient description of a case |
| url | http://dx.doi.org/10.1155/2012/524279 |
| work_keys_str_mv | AT smastrobuoni fataltoxoplasmagondiidisseminationinahearttransplantrecipientdescriptionofacase AT amdellaquila fataltoxoplasmagondiidisseminationinahearttransplantrecipientdescriptionofacase AT jherreros fataltoxoplasmagondiidisseminationinahearttransplantrecipientdescriptionofacase |