Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil
The aim of this study was to investigate possible associations between genetic polymorphisms of IL17A G197A (rs2275913) and IL17F T7488C (rs763780) with Chagas Disease (CD) and/or the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas cardiomyopathy (CCC). The s...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/1017621 |
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| author | Pâmela Guimarães Reis Christiane Maria Ayo Luiz Carlos de Mattos Cinara de Cássia Brandão de Mattos Karina Mayumi Sakita Amarilis Giaretta de Moraes Larissa Pires Muller Julimary Suematsu Aquino Luciana Conci Macedo Priscila Saamara Mazini Ana Maria Sell Divina Seila de Oliveira Marques Reinaldo Bulgarelli Bestetti Jeane Eliete Laguila Visentainer |
| author_facet | Pâmela Guimarães Reis Christiane Maria Ayo Luiz Carlos de Mattos Cinara de Cássia Brandão de Mattos Karina Mayumi Sakita Amarilis Giaretta de Moraes Larissa Pires Muller Julimary Suematsu Aquino Luciana Conci Macedo Priscila Saamara Mazini Ana Maria Sell Divina Seila de Oliveira Marques Reinaldo Bulgarelli Bestetti Jeane Eliete Laguila Visentainer |
| author_sort | Pâmela Guimarães Reis |
| collection | DOAJ |
| description | The aim of this study was to investigate possible associations between genetic polymorphisms of IL17A G197A (rs2275913) and IL17F T7488C (rs763780) with Chagas Disease (CD) and/or the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas cardiomyopathy (CCC). The study with 260 patients and 150 controls was conducted in the South and Southeast regions of Brazil. The genotyping was performed by PCR-RFLP. The A allele and A/A genotype of IL17A were significantly increased in patients and their subgroups (patients with CCC; patients with CCC and LVSD; and patients with CCC and severe LVSD) when compared to the control group. The analysis according to the gender showed that the A/A genotype of IL17A was more frequent in female with LVSD and mild to moderate LVSD and also in male patients with LVSD. The frequency of IL17F T/C genotype was higher in male patients with CCC and severe LVSD and in female with mild to moderate LVSD. The results suggest the possible involvement of the polymorphisms of IL17A and IL17F in the susceptibility to chronic Chagas disease and in development and progression of cardiomyopathy. |
| format | Article |
| id | doaj-art-f305660f39d043789ad0a92503cc65ae |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f305660f39d043789ad0a92503cc65ae2025-02-03T06:14:03ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/10176211017621Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of BrazilPâmela Guimarães Reis0Christiane Maria Ayo1Luiz Carlos de Mattos2Cinara de Cássia Brandão de Mattos3Karina Mayumi Sakita4Amarilis Giaretta de Moraes5Larissa Pires Muller6Julimary Suematsu Aquino7Luciana Conci Macedo8Priscila Saamara Mazini9Ana Maria Sell10Divina Seila de Oliveira Marques11Reinaldo Bulgarelli Bestetti12Jeane Eliete Laguila Visentainer13Post Graduation Program of Biosciences and Physiopathology, Department of Analysis Clinical and Biomedicine, Maringa State University, Maringa, PR, BrazilLaboratory of Immunogenetics, Department of Molecular Biology, Medical School, São José do Rio Preto, SP, BrazilLaboratory of Immunogenetics, Department of Molecular Biology, Medical School, São José do Rio Preto, SP, BrazilLaboratory of Immunogenetics, Department of Molecular Biology, Medical School, São José do Rio Preto, SP, BrazilPost Graduation Program of Biosciences and Physiopathology, Department of Analysis Clinical and Biomedicine, Maringa State University, Maringa, PR, BrazilPost Graduation Program of Biosciences and Physiopathology, Department of Analysis Clinical and Biomedicine, Maringa State University, Maringa, PR, BrazilLaboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State University, Maringa, PR, BrazilPost Graduation Program of Biosciences and Physiopathology, Department of Analysis Clinical and Biomedicine, Maringa State University, Maringa, PR, BrazilPost Graduation Program of Biosciences and Physiopathology, Department of Analysis Clinical and Biomedicine, Maringa State University, Maringa, PR, BrazilPost Graduation Program of Biosciences and Physiopathology, Department of Analysis Clinical and Biomedicine, Maringa State University, Maringa, PR, BrazilPost Graduation Program of Biosciences and Physiopathology, Department of Analysis Clinical and Biomedicine, Maringa State University, Maringa, PR, BrazilDepartment of Medical Clinic, Londrina State University, Londrina, PR, BrazilDepartment of Cardiology and Cardiovascular Surgery, Medical School, São José do Rio Preto, SP, BrazilPost Graduation Program of Biosciences and Physiopathology, Department of Analysis Clinical and Biomedicine, Maringa State University, Maringa, PR, BrazilThe aim of this study was to investigate possible associations between genetic polymorphisms of IL17A G197A (rs2275913) and IL17F T7488C (rs763780) with Chagas Disease (CD) and/or the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas cardiomyopathy (CCC). The study with 260 patients and 150 controls was conducted in the South and Southeast regions of Brazil. The genotyping was performed by PCR-RFLP. The A allele and A/A genotype of IL17A were significantly increased in patients and their subgroups (patients with CCC; patients with CCC and LVSD; and patients with CCC and severe LVSD) when compared to the control group. The analysis according to the gender showed that the A/A genotype of IL17A was more frequent in female with LVSD and mild to moderate LVSD and also in male patients with LVSD. The frequency of IL17F T/C genotype was higher in male patients with CCC and severe LVSD and in female with mild to moderate LVSD. The results suggest the possible involvement of the polymorphisms of IL17A and IL17F in the susceptibility to chronic Chagas disease and in development and progression of cardiomyopathy.http://dx.doi.org/10.1155/2017/1017621 |
| spellingShingle | Pâmela Guimarães Reis Christiane Maria Ayo Luiz Carlos de Mattos Cinara de Cássia Brandão de Mattos Karina Mayumi Sakita Amarilis Giaretta de Moraes Larissa Pires Muller Julimary Suematsu Aquino Luciana Conci Macedo Priscila Saamara Mazini Ana Maria Sell Divina Seila de Oliveira Marques Reinaldo Bulgarelli Bestetti Jeane Eliete Laguila Visentainer Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil Journal of Immunology Research |
| title | Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil |
| title_full | Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil |
| title_fullStr | Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil |
| title_full_unstemmed | Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil |
| title_short | Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil |
| title_sort | genetic polymorphisms of il17 and chagas disease in the south and southeast of brazil |
| url | http://dx.doi.org/10.1155/2017/1017621 |
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