Paraneoplastic Dermatomyositis Associated with Metastatic Seminoma
We report the first case in Japan of paraneoplastic dermatomyositis with pure seminoma, a tumor that extremely rarely accompanies dermatomyositis. The patient presented to the hospital with muscle weakness and erythema and was diagnosed with dermatomyositis from skin biopsy. Routine radiological scr...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2016/7050981 |
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| author | Hidekazu Yoshie Ryuto Nakazawa Wataru Usuba Hiroya Kudo Yuichi Sato Hideo Sasaki Tatsuya Chikaraishi |
| author_facet | Hidekazu Yoshie Ryuto Nakazawa Wataru Usuba Hiroya Kudo Yuichi Sato Hideo Sasaki Tatsuya Chikaraishi |
| author_sort | Hidekazu Yoshie |
| collection | DOAJ |
| description | We report the first case in Japan of paraneoplastic dermatomyositis with pure seminoma, a tumor that extremely rarely accompanies dermatomyositis. The patient presented to the hospital with muscle weakness and erythema and was diagnosed with dermatomyositis from skin biopsy. Routine radiological screening revealed testicular tumor and massive lymph node metastases. We initially performed orchiectomy along with conventional immunotherapy. However, muscle weakness gradually worsened, and he eventually showed dysphagia and forced respiration and became bedridden. Although he seemed close to being too unstable to tolerate further treatment, we started carefully adjusted chemotherapy comprising 4 courses of etoposide plus cisplatin, which proved highly successful. Lymph node metastases completely disappeared and swallowing and respiration fully normalized after completing chemotherapy. We believe that this clinical success was due to our decision to initiate chemotherapy even in such a weak patient. |
| format | Article |
| id | doaj-art-f2f06928bc244d0a9ef78d619fff0b3b |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-f2f06928bc244d0a9ef78d619fff0b3b2025-02-03T01:08:50ZengWileyCase Reports in Urology2090-696X2090-69782016-01-01201610.1155/2016/70509817050981Paraneoplastic Dermatomyositis Associated with Metastatic SeminomaHidekazu Yoshie0Ryuto Nakazawa1Wataru Usuba2Hiroya Kudo3Yuichi Sato4Hideo Sasaki5Tatsuya Chikaraishi6Department of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, JapanDepartment of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, JapanDepartment of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, JapanDepartment of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, JapanDepartment of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, JapanDepartment of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, JapanDepartment of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, JapanWe report the first case in Japan of paraneoplastic dermatomyositis with pure seminoma, a tumor that extremely rarely accompanies dermatomyositis. The patient presented to the hospital with muscle weakness and erythema and was diagnosed with dermatomyositis from skin biopsy. Routine radiological screening revealed testicular tumor and massive lymph node metastases. We initially performed orchiectomy along with conventional immunotherapy. However, muscle weakness gradually worsened, and he eventually showed dysphagia and forced respiration and became bedridden. Although he seemed close to being too unstable to tolerate further treatment, we started carefully adjusted chemotherapy comprising 4 courses of etoposide plus cisplatin, which proved highly successful. Lymph node metastases completely disappeared and swallowing and respiration fully normalized after completing chemotherapy. We believe that this clinical success was due to our decision to initiate chemotherapy even in such a weak patient.http://dx.doi.org/10.1155/2016/7050981 |
| spellingShingle | Hidekazu Yoshie Ryuto Nakazawa Wataru Usuba Hiroya Kudo Yuichi Sato Hideo Sasaki Tatsuya Chikaraishi Paraneoplastic Dermatomyositis Associated with Metastatic Seminoma Case Reports in Urology |
| title | Paraneoplastic Dermatomyositis Associated with Metastatic Seminoma |
| title_full | Paraneoplastic Dermatomyositis Associated with Metastatic Seminoma |
| title_fullStr | Paraneoplastic Dermatomyositis Associated with Metastatic Seminoma |
| title_full_unstemmed | Paraneoplastic Dermatomyositis Associated with Metastatic Seminoma |
| title_short | Paraneoplastic Dermatomyositis Associated with Metastatic Seminoma |
| title_sort | paraneoplastic dermatomyositis associated with metastatic seminoma |
| url | http://dx.doi.org/10.1155/2016/7050981 |
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