Asymptomatic flow of Rosai-Dorfman disease
Introduction. Sinus histiocytosis with massive lymphadenopathy is a rare benign self-limiting disease of unknown etiology. The salivary gland involvement, indicating the extranodal character of the disease, often presents a diagnostic dilemma requiring immunohistochemical staining of sur...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2014-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501408780P.pdf |
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| Summary: | Introduction. Sinus histiocytosis with massive lymphadenopathy is a rare
benign self-limiting disease of unknown etiology. The salivary gland
involvement, indicating the extranodal character of the disease, often
presents a diagnostic dilemma requiring immunohistochemical staining of
surgically removed tumor to confirm the diagnosis. Case report. We report a
43-year-old man presented with an asymptomatic mass in the left mandibular
angle. On physical examination, the lesion was described as a painless,
mobile, firm-elastic consistency nodule, which measured 4 × 3 cm in diameter,
with normal overlying skin. A mass with the same characteristics, dimensions
2 × 2 cm, was also noted in the right parotid region. No other changes in
regional lymph nodes were detected. On macroscopic examination the lesion was
firm, multilobulated, yellowish and rounded, while on microscopic examination
the lesion was composed almost entirely of polygonal histiocytes with
abundant cytoplasm, emperipolesis, plasma cells arranged in sheets, and
lymphocytes scattered or within clusters. The observed histiocytes were found
to be CD68 and S100 protein positive. Conclusion. Rosai-Dorfman disease is a
beningn and frequently overlooked clinical and pathological entity that may
be misinterpreted as a neoplastic disease. [Projekat Ministarstva nauke
Republike Srbije, br. 41017] |
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| ISSN: | 0042-8450 |