A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer’s Disease

A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer’s Disease

We previously reported age of onset (AOO) modifier genes in the world’s largest pedigree segregating early-onset Alzheimer’s disease (AD), caused by the p.Glu280Ala (E280A) mutation in the PSEN1 gene. Here we report the results of a targeted analysis of functional exonic variants in those AOO modifi...

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Main Authors: Jorge I. Vélez, Dora Rivera, Claudio A. Mastronardi, Hardip R. Patel, Carlos Tobón, Andrés Villegas, Yeping Cai, Simon Easteal, Francisco Lopera, Mauricio Arcos-Burgos
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2016/9760314
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http://dx.doi.org/10.1155/2016/9760314

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