A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer’s Disease
We previously reported age of onset (AOO) modifier genes in the world’s largest pedigree segregating early-onset Alzheimer’s disease (AD), caused by the p.Glu280Ala (E280A) mutation in the PSEN1 gene. Here we report the results of a targeted analysis of functional exonic variants in those AOO modifi...
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/9760314 |
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| author | Jorge I. Vélez Dora Rivera Claudio A. Mastronardi Hardip R. Patel Carlos Tobón Andrés Villegas Yeping Cai Simon Easteal Francisco Lopera Mauricio Arcos-Burgos |
| author_facet | Jorge I. Vélez Dora Rivera Claudio A. Mastronardi Hardip R. Patel Carlos Tobón Andrés Villegas Yeping Cai Simon Easteal Francisco Lopera Mauricio Arcos-Burgos |
| author_sort | Jorge I. Vélez |
| collection | DOAJ |
| description | We previously reported age of onset (AOO) modifier genes in the world’s largest pedigree segregating early-onset Alzheimer’s disease (AD), caused by the p.Glu280Ala (E280A) mutation in the PSEN1 gene. Here we report the results of a targeted analysis of functional exonic variants in those AOO modifier genes in sixty individuals with PSEN1 E280A AD who were whole-exome genotyped for ~250,000 variants. Standard quality control, filtering, and annotation for functional variants were applied, and common functional variants located in those previously reported as AOO modifier loci were selected. Multiloci linear mixed-effects models were used to test the association between these variants and AOO. An exonic missense mutation in the G72 (DAOA) gene (rs2391191, P = 1.94 × 10−4, PFDR = 9.34 × 10−3) was found to modify AOO in PSEN1 E280A AD. Nominal associations of missense mutations in the CLUAP1 (rs9790, P = 7.63 × 10−3, PFDR = 0.1832) and EXOC2 (rs17136239, P = 0.0325, PFDR = 0.391) genes were also found. Previous studies have linked polymorphisms in the DAOA gene with the occurrence of neuropsychiatric symptoms such as depression, apathy, aggression, delusions, hallucinations, and psychosis in AD. Our findings strongly suggest that this new conspicuous functional AOO modifier within the G72 (DAOA) gene could be pivotal for understanding the genetic basis of AD. |
| format | Article |
| id | doaj-art-f2d9d4d2b38b48c3be68fc5379b40ead |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-f2d9d4d2b38b48c3be68fc5379b40ead2025-02-03T05:46:06ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/97603149760314A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer’s DiseaseJorge I. Vélez0Dora Rivera1Claudio A. Mastronardi2Hardip R. Patel3Carlos Tobón4Andrés Villegas5Yeping Cai6Simon Easteal7Francisco Lopera8Mauricio Arcos-Burgos9The Arcos-Burgos Group, Department of Genome Sciences, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2600, AustraliaNeuroscience Research Group, University of Antioquia, Medellín, ColombiaThe Arcos-Burgos Group, Department of Genome Sciences, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2600, AustraliaThe Arcos-Burgos Group, Department of Genome Sciences, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2600, AustraliaNeuroscience Research Group, University of Antioquia, Medellín, ColombiaNeuroscience Research Group, University of Antioquia, Medellín, ColombiaThe Arcos-Burgos Group, Department of Genome Sciences, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2600, AustraliaThe Easteal Group, Department of Genome Sciences, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2600, AustraliaNeuroscience Research Group, University of Antioquia, Medellín, ColombiaThe Arcos-Burgos Group, Department of Genome Sciences, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2600, AustraliaWe previously reported age of onset (AOO) modifier genes in the world’s largest pedigree segregating early-onset Alzheimer’s disease (AD), caused by the p.Glu280Ala (E280A) mutation in the PSEN1 gene. Here we report the results of a targeted analysis of functional exonic variants in those AOO modifier genes in sixty individuals with PSEN1 E280A AD who were whole-exome genotyped for ~250,000 variants. Standard quality control, filtering, and annotation for functional variants were applied, and common functional variants located in those previously reported as AOO modifier loci were selected. Multiloci linear mixed-effects models were used to test the association between these variants and AOO. An exonic missense mutation in the G72 (DAOA) gene (rs2391191, P = 1.94 × 10−4, PFDR = 9.34 × 10−3) was found to modify AOO in PSEN1 E280A AD. Nominal associations of missense mutations in the CLUAP1 (rs9790, P = 7.63 × 10−3, PFDR = 0.1832) and EXOC2 (rs17136239, P = 0.0325, PFDR = 0.391) genes were also found. Previous studies have linked polymorphisms in the DAOA gene with the occurrence of neuropsychiatric symptoms such as depression, apathy, aggression, delusions, hallucinations, and psychosis in AD. Our findings strongly suggest that this new conspicuous functional AOO modifier within the G72 (DAOA) gene could be pivotal for understanding the genetic basis of AD.http://dx.doi.org/10.1155/2016/9760314 |
| spellingShingle | Jorge I. Vélez Dora Rivera Claudio A. Mastronardi Hardip R. Patel Carlos Tobón Andrés Villegas Yeping Cai Simon Easteal Francisco Lopera Mauricio Arcos-Burgos A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer’s Disease Neural Plasticity |
| title | A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer’s Disease |
| title_full | A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer’s Disease |
| title_fullStr | A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer’s Disease |
| title_full_unstemmed | A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer’s Disease |
| title_short | A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer’s Disease |
| title_sort | mutation in daoa modifies the age of onset in psen1 e280a alzheimer s disease |
| url | http://dx.doi.org/10.1155/2016/9760314 |
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