Progress of studies on sclerostin’s role in vascular calcification of chronic kidney disease
As an essential messenger between bones and vessel axis,sclerostin plays a key role in development and progression of vascular calcification;however,its mechanism is complicated.Current studies have demonstrated,sclerostin is an osteocyte-specific glycoprotein,which is considered as an effective inh...
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| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2019-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57913897&Fpath=home&index=0 |
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| Summary: | As an essential messenger between bones and vessel axis,sclerostin plays a key role in development and progression of vascular calcification;however,its mechanism is complicated.Current studies have demonstrated,sclerostin is an osteocyte-specific glycoprotein,which is considered as an effective inhibitor of bone formation;its biological effects are exerted by inhibiting the specific co-receptors required for Wnt/β-catenin signaling activation.Thus,serum sclerostin levels may reflect bone metabolism,and may be used as a marker of low and middle turnover bone disease and renal osteodystrophy in patients with end stage renal disease(ESRD).In spite of this,anti-sclerostin antibodies may be a novel therapy.This article is supposed to understand basic structure and biological activity of sclerostin,meanwhile review its relationship with chronic kidney diseases and vascular calcification,and comp up with application of anti-sclerostin antibody therapy in patients with CKD. |
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| ISSN: | 1671-2390 |