Application Strategies of Super-Enhancer RNA in Cardiovascular Diseases
Cardiovascular diseases (CVDs) are a leading cause of death worldwide, and new therapeutic strategies are urgently needed. In recent years, enhancer RNAs (eRNAs) have gradually attracted attention because they offer new directions for the treatment of CVDs. Super-enhancer RNAs (seRNAs) are a subset...
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| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/1/117 |
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| author | Yi He Yuwei Cai Yanyan Cao Yan Wang Jing Wang Hu Ding |
| author_facet | Yi He Yuwei Cai Yanyan Cao Yan Wang Jing Wang Hu Ding |
| author_sort | Yi He |
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| description | Cardiovascular diseases (CVDs) are a leading cause of death worldwide, and new therapeutic strategies are urgently needed. In recent years, enhancer RNAs (eRNAs) have gradually attracted attention because they offer new directions for the treatment of CVDs. Super-enhancer RNAs (seRNAs) are a subset of non-coding RNAs that are transcribed from regions of the genome known as super enhancers, which are large clusters of enhancers with a high density of transcription factors and cofactors. These regions play a pivotal role in regulating genes involved in cell identity and disease progression. This article reviews the characteristics of seRNAs, their expression patterns, and regulatory mechanisms in the cardiovascular system. We also explore their role in the occurrence and development of CVDs, as well as their potential as diagnostic biomarkers and therapeutic targets. Currently, therapies targeting seRNAs are a research hotspot. The development of specific inhibitors or activators is expected to facilitate precise interventions for CVDs. In addition, the use of gene editing techniques to modify relevant eRNA introduces new possibilities for disease treatment. This review aims to provide a comprehensive overview of seRNAs in CVDs and discusses their potential as a novel class of therapeutic targets. |
| format | Article |
| id | doaj-art-f2c136d08f604743a0bd80326228e865 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-f2c136d08f604743a0bd80326228e8652025-01-24T13:24:04ZengMDPI AGBiomedicines2227-90592025-01-0113111710.3390/biomedicines13010117Application Strategies of Super-Enhancer RNA in Cardiovascular DiseasesYi He0Yuwei Cai1Yanyan Cao2Yan Wang3Jing Wang4Hu Ding5Division of Cardiology, Departments of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDivision of Cardiology, Departments of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDivision of Cardiology, Departments of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDivision of Cardiology, Departments of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDivision of Cardiology, Departments of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDivision of Cardiology, Departments of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaCardiovascular diseases (CVDs) are a leading cause of death worldwide, and new therapeutic strategies are urgently needed. In recent years, enhancer RNAs (eRNAs) have gradually attracted attention because they offer new directions for the treatment of CVDs. Super-enhancer RNAs (seRNAs) are a subset of non-coding RNAs that are transcribed from regions of the genome known as super enhancers, which are large clusters of enhancers with a high density of transcription factors and cofactors. These regions play a pivotal role in regulating genes involved in cell identity and disease progression. This article reviews the characteristics of seRNAs, their expression patterns, and regulatory mechanisms in the cardiovascular system. We also explore their role in the occurrence and development of CVDs, as well as their potential as diagnostic biomarkers and therapeutic targets. Currently, therapies targeting seRNAs are a research hotspot. The development of specific inhibitors or activators is expected to facilitate precise interventions for CVDs. In addition, the use of gene editing techniques to modify relevant eRNA introduces new possibilities for disease treatment. This review aims to provide a comprehensive overview of seRNAs in CVDs and discusses their potential as a novel class of therapeutic targets.https://www.mdpi.com/2227-9059/13/1/117cardiovascular diseases (CVDs)enhancer RNA (eRNA)super-enhancer RNA (seRNA) |
| spellingShingle | Yi He Yuwei Cai Yanyan Cao Yan Wang Jing Wang Hu Ding Application Strategies of Super-Enhancer RNA in Cardiovascular Diseases Biomedicines cardiovascular diseases (CVDs) enhancer RNA (eRNA) super-enhancer RNA (seRNA) |
| title | Application Strategies of Super-Enhancer RNA in Cardiovascular Diseases |
| title_full | Application Strategies of Super-Enhancer RNA in Cardiovascular Diseases |
| title_fullStr | Application Strategies of Super-Enhancer RNA in Cardiovascular Diseases |
| title_full_unstemmed | Application Strategies of Super-Enhancer RNA in Cardiovascular Diseases |
| title_short | Application Strategies of Super-Enhancer RNA in Cardiovascular Diseases |
| title_sort | application strategies of super enhancer rna in cardiovascular diseases |
| topic | cardiovascular diseases (CVDs) enhancer RNA (eRNA) super-enhancer RNA (seRNA) |
| url | https://www.mdpi.com/2227-9059/13/1/117 |
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