Nonrhabdomyosarcomatous abdominopelvic sarcomas: Analysis of prognostic factors
Background: Data concerning treatment outcome and prognostic factors in sarcomas of abdomen and pelvis are sparse in literature.Methods and Results: Of 696 patients with nonrhabdomyosarcomatous soft tissue sarcoma registered at our center between June 2003 and December 2012, 112 (16%) patients of sa...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2016-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2016;volume=37;issue=2;spage=100;epage=105;aulast=Iqbal |
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| author | Nida Iqbal Nootan K Shukla S. V. S. Deo Sandeep Agarwala D N Sharma Meher C Sharma Sameer Bakhshi |
| author_facet | Nida Iqbal Nootan K Shukla S. V. S. Deo Sandeep Agarwala D N Sharma Meher C Sharma Sameer Bakhshi |
| author_sort | Nida Iqbal |
| collection | DOAJ |
| description | Background: Data concerning treatment outcome and prognostic factors in sarcomas of abdomen and pelvis are sparse in literature.Methods and Results: Of 696 patients with nonrhabdomyosarcomatous soft tissue sarcoma registered at our center between June 2003 and December 2012, 112 (16%) patients of sarcomas arising from abdomen and pelvis were identified, of which 88 patients were analyzed for treatment outcome and prognostic factors. The median age was 40 years (range: 1–78 years) with a male: female ratio of 0.7:1. Twenty-one (24%) patients were metastatic at baseline. The most common tumor sites were retroperitoneum in 70% patients and abdominal wall in 18% patients. Leiomyosarcoma was the most common histological subtype in 36% patients followed by liposarcoma in 17% patients. Thirty-five (40%) patients had Grade III tumors. Forty-six (52%) patients underwent surgical resection. At a median follow-up of 43 months (range: 2–94 months), the 5-year event-free survival (EFS) and overall survival (OS) were 35% and 42%, with a median of 22 months and 43 months, respectively. Multivariate analysis identified male gender (P - 0.03, hazard ratio [HR] - 0.46, 95% confidence interval [CI] - 0.23–0.92), baseline metastatic disease (P - 0.01, HR - 2.98, 95% CI - 1.27–6.98) and Grade III tumors (P - 0.02, HR - 1.84, 95% CI - 1.08–3.13) as factors associated with poor EFS, whereas baseline metastatic disease (P < 0.001, HR - 5.45, 95% CI - 2.31–12.87) and unresectability (P - 0.01, HR - 2.72, 95% CI - 1.27–5.83) were associated with poor OS. Conclusion: This is a single-institutional study of patients with abdominopelvic sarcomas where gender was identified as a new factor affecting survival apart from baseline presentation, histologic grade, and surgical resection. |
| format | Article |
| id | doaj-art-f2bfe7912d75445a8aeefc0a7af3dba6 |
| institution | OA Journals |
| issn | 0971-5851 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-f2bfe7912d75445a8aeefc0a7af3dba62025-08-20T02:21:58ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512016-01-0137210010510.4103/0971-5851.180134Nonrhabdomyosarcomatous abdominopelvic sarcomas: Analysis of prognostic factorsNida IqbalNootan K ShuklaS. V. S. DeoSandeep AgarwalaD N SharmaMeher C SharmaSameer BakhshiBackground: Data concerning treatment outcome and prognostic factors in sarcomas of abdomen and pelvis are sparse in literature.Methods and Results: Of 696 patients with nonrhabdomyosarcomatous soft tissue sarcoma registered at our center between June 2003 and December 2012, 112 (16%) patients of sarcomas arising from abdomen and pelvis were identified, of which 88 patients were analyzed for treatment outcome and prognostic factors. The median age was 40 years (range: 1–78 years) with a male: female ratio of 0.7:1. Twenty-one (24%) patients were metastatic at baseline. The most common tumor sites were retroperitoneum in 70% patients and abdominal wall in 18% patients. Leiomyosarcoma was the most common histological subtype in 36% patients followed by liposarcoma in 17% patients. Thirty-five (40%) patients had Grade III tumors. Forty-six (52%) patients underwent surgical resection. At a median follow-up of 43 months (range: 2–94 months), the 5-year event-free survival (EFS) and overall survival (OS) were 35% and 42%, with a median of 22 months and 43 months, respectively. Multivariate analysis identified male gender (P - 0.03, hazard ratio [HR] - 0.46, 95% confidence interval [CI] - 0.23–0.92), baseline metastatic disease (P - 0.01, HR - 2.98, 95% CI - 1.27–6.98) and Grade III tumors (P - 0.02, HR - 1.84, 95% CI - 1.08–3.13) as factors associated with poor EFS, whereas baseline metastatic disease (P < 0.001, HR - 5.45, 95% CI - 2.31–12.87) and unresectability (P - 0.01, HR - 2.72, 95% CI - 1.27–5.83) were associated with poor OS. Conclusion: This is a single-institutional study of patients with abdominopelvic sarcomas where gender was identified as a new factor affecting survival apart from baseline presentation, histologic grade, and surgical resection.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2016;volume=37;issue=2;spage=100;epage=105;aulast=IqbalAbdomen, gender, pelvis, prognostic factors, sarcoma |
| spellingShingle | Nida Iqbal Nootan K Shukla S. V. S. Deo Sandeep Agarwala D N Sharma Meher C Sharma Sameer Bakhshi Nonrhabdomyosarcomatous abdominopelvic sarcomas: Analysis of prognostic factors Indian Journal of Medical and Paediatric Oncology Abdomen, gender, pelvis, prognostic factors, sarcoma |
| title | Nonrhabdomyosarcomatous abdominopelvic sarcomas: Analysis of prognostic factors |
| title_full | Nonrhabdomyosarcomatous abdominopelvic sarcomas: Analysis of prognostic factors |
| title_fullStr | Nonrhabdomyosarcomatous abdominopelvic sarcomas: Analysis of prognostic factors |
| title_full_unstemmed | Nonrhabdomyosarcomatous abdominopelvic sarcomas: Analysis of prognostic factors |
| title_short | Nonrhabdomyosarcomatous abdominopelvic sarcomas: Analysis of prognostic factors |
| title_sort | nonrhabdomyosarcomatous abdominopelvic sarcomas analysis of prognostic factors |
| topic | Abdomen, gender, pelvis, prognostic factors, sarcoma |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2016;volume=37;issue=2;spage=100;epage=105;aulast=Iqbal |
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