Elicitation of liver-stage immunity by nanoparticle immunogens displaying P. falciparum CSP-derived antigens

Elicitation of liver-stage immunity by nanoparticle immunogens displaying P. falciparum CSP-derived antigens

Abstract A vaccine that provides robust, durable protection against malaria remains a global health priority. Although a breakthrough in the fight against malaria has recently been achieved by the licensure of two vaccines based on the circumsporozoite protein (CSP), the effectiveness and durability...

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Main Authors: Mark D. Langowski, Joseph R. Francica, Alex L. Roederer, Nicholas K. Hurlburt, Justas V. Rodarte, Lais Da Silva Pereira, Barbara J. Flynn, Brian Bonilla, Marlon Dillon, Patience Kiyuka, Rashmi Ravichandran, Connor Weidle, Lauren Carter, Mangala Rao, Gary R. Matyas, Marion Pepper, Azza H. Idris, Robert A. Seder, Marie Pancera, Neil P. King
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01140-x
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https://doi.org/10.1038/s41541-025-01140-x

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