Estimating Kidney Function in the Critically Ill Patients
Glomerular filtration rate (GFR) is an accepted measure for assessment of kidney function. For the critically ill patient, creatinine clearance is the method of reference for the estimation of the GFR, although this is often not measured but estimated by equations (i.e., Cockroft-Gault or MDRD) not...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/721810 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564648111505408 |
|---|---|
| author | Gemma Seller-Pérez Manuel E. Herrera-Gutiérrez Javier Maynar-Moliner José A. Sánchez-Izquierdo-Riera Anibal Marinho José Luis do Pico |
| author_facet | Gemma Seller-Pérez Manuel E. Herrera-Gutiérrez Javier Maynar-Moliner José A. Sánchez-Izquierdo-Riera Anibal Marinho José Luis do Pico |
| author_sort | Gemma Seller-Pérez |
| collection | DOAJ |
| description | Glomerular filtration rate (GFR) is an accepted measure for assessment of kidney function. For the critically ill patient, creatinine clearance is the method of reference for the estimation of the GFR, although this is often not measured but estimated by equations (i.e., Cockroft-Gault or MDRD) not well suited for the critically ill patient. Functional evaluation of the kidney rests in serum creatinine (Crs) that is subjected to multiple external factors, especially relevant overhydration and loss of muscle mass. The laboratory method used introduces variations in Crs, an important fact considering that small increases in Crs have serious repercussion on the prognosis of patients. Efforts directed to stratify the risk of acute kidney injury (AKI) have crystallized in the RIFLE or AKIN systems, based in sequential changes in Crs or urine flow. These systems have provided a common definition of AKI and, due to their sensitivity, have meant a considerable advantage for the clinical practice but, on the other side, have introduced an uncertainty in clinical research because of potentially overestimating AKI incidence. Another significant drawback is the unavoidable period of time needed before a patient is classified, and this is perhaps the problem to be overcome in the near future. |
| format | Article |
| id | doaj-art-f2b4d857901347bd933ea0e937dc9435 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-f2b4d857901347bd933ea0e937dc94352025-02-03T01:10:31ZengWileyCritical Care Research and Practice2090-13052090-13132013-01-01201310.1155/2013/721810721810Estimating Kidney Function in the Critically Ill PatientsGemma Seller-Pérez0Manuel E. Herrera-Gutiérrez1Javier Maynar-Moliner2José A. Sánchez-Izquierdo-Riera3Anibal Marinho4José Luis do Pico5Department of Critical Care Medicine, University Hospital Carlos Haya, 29018 Malaga, SpainDepartment of Critical Care Medicine, University Hospital Carlos Haya, 29018 Malaga, SpainDepartment of Critical Care Medicine, Santiago Hospital, Vitoria, SpainDepartment of Critical Care Medicine, Hospital 12 de Octubre, Madrid, SpainDepartment of Critical Care Medicine, Centro Hospitalario de Porto, PortugalDepartment of Critical Care Medicine, Hospital Municipal de Necochea, ArgentinaGlomerular filtration rate (GFR) is an accepted measure for assessment of kidney function. For the critically ill patient, creatinine clearance is the method of reference for the estimation of the GFR, although this is often not measured but estimated by equations (i.e., Cockroft-Gault or MDRD) not well suited for the critically ill patient. Functional evaluation of the kidney rests in serum creatinine (Crs) that is subjected to multiple external factors, especially relevant overhydration and loss of muscle mass. The laboratory method used introduces variations in Crs, an important fact considering that small increases in Crs have serious repercussion on the prognosis of patients. Efforts directed to stratify the risk of acute kidney injury (AKI) have crystallized in the RIFLE or AKIN systems, based in sequential changes in Crs or urine flow. These systems have provided a common definition of AKI and, due to their sensitivity, have meant a considerable advantage for the clinical practice but, on the other side, have introduced an uncertainty in clinical research because of potentially overestimating AKI incidence. Another significant drawback is the unavoidable period of time needed before a patient is classified, and this is perhaps the problem to be overcome in the near future.http://dx.doi.org/10.1155/2013/721810 |
| spellingShingle | Gemma Seller-Pérez Manuel E. Herrera-Gutiérrez Javier Maynar-Moliner José A. Sánchez-Izquierdo-Riera Anibal Marinho José Luis do Pico Estimating Kidney Function in the Critically Ill Patients Critical Care Research and Practice |
| title | Estimating Kidney Function in the Critically Ill Patients |
| title_full | Estimating Kidney Function in the Critically Ill Patients |
| title_fullStr | Estimating Kidney Function in the Critically Ill Patients |
| title_full_unstemmed | Estimating Kidney Function in the Critically Ill Patients |
| title_short | Estimating Kidney Function in the Critically Ill Patients |
| title_sort | estimating kidney function in the critically ill patients |
| url | http://dx.doi.org/10.1155/2013/721810 |
| work_keys_str_mv | AT gemmasellerperez estimatingkidneyfunctioninthecriticallyillpatients AT manueleherreragutierrez estimatingkidneyfunctioninthecriticallyillpatients AT javiermaynarmoliner estimatingkidneyfunctioninthecriticallyillpatients AT joseasanchezizquierdoriera estimatingkidneyfunctioninthecriticallyillpatients AT anibalmarinho estimatingkidneyfunctioninthecriticallyillpatients AT joseluisdopico estimatingkidneyfunctioninthecriticallyillpatients |