Oral Local Anesthesia Successfully Ameliorated Neuropathic Pain in an Upper Limb Suggesting Pain Alleviation through Neural Plasticity within the Central Nervous System: A Case Report
Neural blockades are considered an alternative to pharmacotherapy for neuropathic pain although these blockades elicit limited effects. We encountered a patient with postbrachial plexus avulsion injury pain, which was refractory to conventional treatments but disappeared temporarily with the adminis...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Anesthesiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2011/984281 |
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| author | Jun Hozumi Masahiko Sumitani Arito Yozu Toshiya Tomioka Hiroshi Sekiyama Satoru Miyauchi Yoshitsugu Yamada |
| author_facet | Jun Hozumi Masahiko Sumitani Arito Yozu Toshiya Tomioka Hiroshi Sekiyama Satoru Miyauchi Yoshitsugu Yamada |
| author_sort | Jun Hozumi |
| collection | DOAJ |
| description | Neural blockades are considered an alternative to pharmacotherapy for neuropathic pain although these blockades elicit limited effects. We encountered a patient with postbrachial plexus avulsion injury pain, which was refractory to conventional treatments but disappeared temporarily with the administration of the local anesthetic lidocaine around the left mandibular molar tooth during dental treatments. This analgesic effect on neuropathic pain by oral local anesthesia was reproducible. Under conditions of neuropathic pain, cerebral somatotopic reorganization in the sensorimotor cortices of the brain has been observed. Either expansion or shrinkage of the somatotopic representation of a deafferentated body part correlates with the degree of neuropathic pain. In our case, administration of an oral local anesthetic shrank the somatotopic representation of the mouth, which is next to the upper limb representation and thereby expanded the upper limb representation in a normal manner. Consequently, oral local anesthesia improved the pain in the upper limb. This case suggests that pain alleviation through neural plasticity within the brain is related to neural blockade. |
| format | Article |
| id | doaj-art-f2b19d5c79e64e1abeab78e53cf78de3 |
| institution | Kabale University |
| issn | 1687-6962 1687-6970 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anesthesiology Research and Practice |
| spelling | doaj-art-f2b19d5c79e64e1abeab78e53cf78de32025-02-03T01:21:29ZengWileyAnesthesiology Research and Practice1687-69621687-69702011-01-01201110.1155/2011/984281984281Oral Local Anesthesia Successfully Ameliorated Neuropathic Pain in an Upper Limb Suggesting Pain Alleviation through Neural Plasticity within the Central Nervous System: A Case ReportJun Hozumi0Masahiko Sumitani1Arito Yozu2Toshiya Tomioka3Hiroshi Sekiyama4Satoru Miyauchi5Yoshitsugu Yamada6Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Rehabilitation Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanKobe Advanced ICT Research Center, National Institute of Information and Communications Technology, Kobe 651-2492, JapanDepartment of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanNeural blockades are considered an alternative to pharmacotherapy for neuropathic pain although these blockades elicit limited effects. We encountered a patient with postbrachial plexus avulsion injury pain, which was refractory to conventional treatments but disappeared temporarily with the administration of the local anesthetic lidocaine around the left mandibular molar tooth during dental treatments. This analgesic effect on neuropathic pain by oral local anesthesia was reproducible. Under conditions of neuropathic pain, cerebral somatotopic reorganization in the sensorimotor cortices of the brain has been observed. Either expansion or shrinkage of the somatotopic representation of a deafferentated body part correlates with the degree of neuropathic pain. In our case, administration of an oral local anesthetic shrank the somatotopic representation of the mouth, which is next to the upper limb representation and thereby expanded the upper limb representation in a normal manner. Consequently, oral local anesthesia improved the pain in the upper limb. This case suggests that pain alleviation through neural plasticity within the brain is related to neural blockade.http://dx.doi.org/10.1155/2011/984281 |
| spellingShingle | Jun Hozumi Masahiko Sumitani Arito Yozu Toshiya Tomioka Hiroshi Sekiyama Satoru Miyauchi Yoshitsugu Yamada Oral Local Anesthesia Successfully Ameliorated Neuropathic Pain in an Upper Limb Suggesting Pain Alleviation through Neural Plasticity within the Central Nervous System: A Case Report Anesthesiology Research and Practice |
| title | Oral Local Anesthesia Successfully Ameliorated Neuropathic Pain in
an Upper Limb Suggesting Pain Alleviation through Neural
Plasticity within the Central Nervous System: A Case Report |
| title_full | Oral Local Anesthesia Successfully Ameliorated Neuropathic Pain in
an Upper Limb Suggesting Pain Alleviation through Neural
Plasticity within the Central Nervous System: A Case Report |
| title_fullStr | Oral Local Anesthesia Successfully Ameliorated Neuropathic Pain in
an Upper Limb Suggesting Pain Alleviation through Neural
Plasticity within the Central Nervous System: A Case Report |
| title_full_unstemmed | Oral Local Anesthesia Successfully Ameliorated Neuropathic Pain in
an Upper Limb Suggesting Pain Alleviation through Neural
Plasticity within the Central Nervous System: A Case Report |
| title_short | Oral Local Anesthesia Successfully Ameliorated Neuropathic Pain in
an Upper Limb Suggesting Pain Alleviation through Neural
Plasticity within the Central Nervous System: A Case Report |
| title_sort | oral local anesthesia successfully ameliorated neuropathic pain in an upper limb suggesting pain alleviation through neural plasticity within the central nervous system a case report |
| url | http://dx.doi.org/10.1155/2011/984281 |
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