The Potential of Neonatal Organ Donation in Central Sweden
Pediatric organ transplant recipients have a higher risk for wait list mortality due to the scarcity of size matched organs. Neonatal organ donation could potentially ameliorate the discrepancy but is currently not implemented in Sweden. This study aims to evaluate the potential of neonatal organ do...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-01-01
|
| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/09636897241303269 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586546266505216 |
|---|---|
| author | Emil Bluhme Ewa Henckel Boubou Hallberg Carl Jorns |
| author_facet | Emil Bluhme Ewa Henckel Boubou Hallberg Carl Jorns |
| author_sort | Emil Bluhme |
| collection | DOAJ |
| description | Pediatric organ transplant recipients have a higher risk for wait list mortality due to the scarcity of size matched organs. Neonatal organ donation could potentially ameliorate the discrepancy but is currently not implemented in Sweden. This study aims to evaluate the potential of neonatal organ donation in central Sweden using a standardized protocol with organ specific criteria. Data on 2,061 neonates who deceased in central Sweden from 2006 to 2016 were collected; 308 neonates met criteria for possible donation. Medical records of all possible donors were reviewed, identifying 85 potential donors. Main cause of death was hypoxic ischemic encephalopathy 47% (n = 40). Median weight was 2,355 (IQR: 1,953) g, with 31% receiving inotropic support. Median creatinine of 72 (IQR: 67) µmol/l, urine production 3 (IQR: 2.2) ml/kg/h, ALT 0.51 (IQR: 1.5) µkat/l, and AST 1.7 (IQR: 3.1) µkat/l. Criteria for kidney donation was met in 39 potential neonatal, 29 for liver and 18 for heart, corresponding to a potential increase of 1.9, 1.4, and 0.9 donors PMP per year, respectively. In total, 16 neonates had a catastrophic neurological injury in combination with lack of brainstem reflexes, indicating plausibility of donation after brain death. Expanding organ donation into the neonatal period in Sweden could lead to an increase in organs available for transplant. |
| format | Article |
| id | doaj-art-f2b1308b52384266b2636f4241b0a455 |
| institution | Kabale University |
| issn | 1555-3892 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj-art-f2b1308b52384266b2636f4241b0a4552025-01-25T10:03:33ZengSAGE PublishingCell Transplantation1555-38922025-01-013410.1177/09636897241303269The Potential of Neonatal Organ Donation in Central SwedenEmil Bluhme0Ewa Henckel1Boubou Hallberg2Carl Jorns3Department of Transplantation, Karolinska University Hospital, Stockholm, SwedenDepartment of Neonatology, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, SwedenDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, SwedenDepartment of Transplantation, Karolinska University Hospital, Stockholm, SwedenPediatric organ transplant recipients have a higher risk for wait list mortality due to the scarcity of size matched organs. Neonatal organ donation could potentially ameliorate the discrepancy but is currently not implemented in Sweden. This study aims to evaluate the potential of neonatal organ donation in central Sweden using a standardized protocol with organ specific criteria. Data on 2,061 neonates who deceased in central Sweden from 2006 to 2016 were collected; 308 neonates met criteria for possible donation. Medical records of all possible donors were reviewed, identifying 85 potential donors. Main cause of death was hypoxic ischemic encephalopathy 47% (n = 40). Median weight was 2,355 (IQR: 1,953) g, with 31% receiving inotropic support. Median creatinine of 72 (IQR: 67) µmol/l, urine production 3 (IQR: 2.2) ml/kg/h, ALT 0.51 (IQR: 1.5) µkat/l, and AST 1.7 (IQR: 3.1) µkat/l. Criteria for kidney donation was met in 39 potential neonatal, 29 for liver and 18 for heart, corresponding to a potential increase of 1.9, 1.4, and 0.9 donors PMP per year, respectively. In total, 16 neonates had a catastrophic neurological injury in combination with lack of brainstem reflexes, indicating plausibility of donation after brain death. Expanding organ donation into the neonatal period in Sweden could lead to an increase in organs available for transplant.https://doi.org/10.1177/09636897241303269 |
| spellingShingle | Emil Bluhme Ewa Henckel Boubou Hallberg Carl Jorns The Potential of Neonatal Organ Donation in Central Sweden Cell Transplantation |
| title | The Potential of Neonatal Organ Donation in Central Sweden |
| title_full | The Potential of Neonatal Organ Donation in Central Sweden |
| title_fullStr | The Potential of Neonatal Organ Donation in Central Sweden |
| title_full_unstemmed | The Potential of Neonatal Organ Donation in Central Sweden |
| title_short | The Potential of Neonatal Organ Donation in Central Sweden |
| title_sort | potential of neonatal organ donation in central sweden |
| url | https://doi.org/10.1177/09636897241303269 |
| work_keys_str_mv | AT emilbluhme thepotentialofneonatalorgandonationincentralsweden AT ewahenckel thepotentialofneonatalorgandonationincentralsweden AT boubouhallberg thepotentialofneonatalorgandonationincentralsweden AT carljorns thepotentialofneonatalorgandonationincentralsweden AT emilbluhme potentialofneonatalorgandonationincentralsweden AT ewahenckel potentialofneonatalorgandonationincentralsweden AT boubouhallberg potentialofneonatalorgandonationincentralsweden AT carljorns potentialofneonatalorgandonationincentralsweden |