Association of uric acid with the decline in estimated glomerular filtration rate in middle-aged and elderly populations: evidence based on the China Health and Retirement Longitudinal Study
Objective Whether uric acid (UA) has an effect on renal function remains controversial. We aimed to investigate the association between serum UA with the decline in estimated glomerular filtration rate (eGFR) in middle-aged and elderly populations in the China Health and Retirement Longitudinal Stud...
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BMJ Publishing Group
2023-05-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/5/e071771.full |
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| author | Ying Liang Ming Lei Liu Lin Peijia Liu Sini Cui Kaiyuan Hu Xinning Shao |
| author_facet | Ying Liang Ming Lei Liu Lin Peijia Liu Sini Cui Kaiyuan Hu Xinning Shao |
| author_sort | Ying Liang |
| collection | DOAJ |
| description | Objective Whether uric acid (UA) has an effect on renal function remains controversial. We aimed to investigate the association between serum UA with the decline in estimated glomerular filtration rate (eGFR) in middle-aged and elderly populations in the China Health and Retirement Longitudinal Study (CHARLS).Design Longitudinal cohort study.Setting This was a second analysis of a public dataset (CHARLS).Participants In this study, 4538 middle-aged and elderly individuals were screened after removing individuals younger than 45 years old, with kidney disease, malignant tumour and missing values.Outcome measures Blood tests were performed both in 2011 and 2015. Decline in eGFR was defined as an eGFR decrease of more than 25% or deterioration of the eGFR stage during the 4-year follow-up period. Logistic models corrected for multiple covariables were used to analyse the association of UA with the decline in eGFR.Results The median (IQR) concentrations of serum UA grouped by quartiles were 3.1 (0.6), 3.9 (0.3), 4.6 (0.4) and 5.7 (1.0) mg/dL, respectively. After multivariable adjustment, the OR of the decline in eGFR was higher for quartile 2 (3.5–<4.2 mg/dL: OR 1.44; 95% CI 1.07 to 1.64; p<0.01), quartile 3 (4.2–<5.0 mg/dL: OR 1.72; 95% CI 1.36 to 2.18; p<0.001) and quartile 4 (≥5.0 mg/dL: OR 2.04; 95% CI 1.58 to 2.63; p<0.001) when compared with quartile 1 (<3.5 mg/dL), and the p value for the trend was <0.001.Conclusions Over a 4-year follow-up period, we found that elevated UA was associated with a decline in eGFR in the middle-aged and elderly individuals with normal renal function. |
| format | Article |
| id | doaj-art-f2af1980a52a46a3a0f242e8a18aedd8 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-f2af1980a52a46a3a0f242e8a18aedd82025-02-02T06:00:10ZengBMJ Publishing GroupBMJ Open2044-60552023-05-0113510.1136/bmjopen-2023-071771Association of uric acid with the decline in estimated glomerular filtration rate in middle-aged and elderly populations: evidence based on the China Health and Retirement Longitudinal StudyYing Liang0Ming Lei1Liu Lin2Peijia Liu3Sini Cui4Kaiyuan Hu5Xinning Shao6Department of Nephrology, Guangzhou Eighth People`s Hospital, Guangzhou, Guangdong, ChinaThe First People`s Hospital of Changde City, Changde, Hunan, ChinaDepartment of Nephrology, Guangzhou Eighth People`s Hospital, Guangzhou, Guangdong, ChinaDepartment of Nephrology, Guangzhou Eighth People`s Hospital, Guangzhou, Guangdong, ChinaDepartment of Nephrology, Guangzhou Eighth People`s Hospital, Guangzhou, Guangdong, ChinaDepartment of Nephrology, Guangzhou Eighth People`s Hospital, Guangzhou, Guangdong, ChinaDepartment of Nephrology, Guangzhou Eighth People`s Hospital, Guangzhou, Guangdong, ChinaObjective Whether uric acid (UA) has an effect on renal function remains controversial. We aimed to investigate the association between serum UA with the decline in estimated glomerular filtration rate (eGFR) in middle-aged and elderly populations in the China Health and Retirement Longitudinal Study (CHARLS).Design Longitudinal cohort study.Setting This was a second analysis of a public dataset (CHARLS).Participants In this study, 4538 middle-aged and elderly individuals were screened after removing individuals younger than 45 years old, with kidney disease, malignant tumour and missing values.Outcome measures Blood tests were performed both in 2011 and 2015. Decline in eGFR was defined as an eGFR decrease of more than 25% or deterioration of the eGFR stage during the 4-year follow-up period. Logistic models corrected for multiple covariables were used to analyse the association of UA with the decline in eGFR.Results The median (IQR) concentrations of serum UA grouped by quartiles were 3.1 (0.6), 3.9 (0.3), 4.6 (0.4) and 5.7 (1.0) mg/dL, respectively. After multivariable adjustment, the OR of the decline in eGFR was higher for quartile 2 (3.5–<4.2 mg/dL: OR 1.44; 95% CI 1.07 to 1.64; p<0.01), quartile 3 (4.2–<5.0 mg/dL: OR 1.72; 95% CI 1.36 to 2.18; p<0.001) and quartile 4 (≥5.0 mg/dL: OR 2.04; 95% CI 1.58 to 2.63; p<0.001) when compared with quartile 1 (<3.5 mg/dL), and the p value for the trend was <0.001.Conclusions Over a 4-year follow-up period, we found that elevated UA was associated with a decline in eGFR in the middle-aged and elderly individuals with normal renal function.https://bmjopen.bmj.com/content/13/5/e071771.full |
| spellingShingle | Ying Liang Ming Lei Liu Lin Peijia Liu Sini Cui Kaiyuan Hu Xinning Shao Association of uric acid with the decline in estimated glomerular filtration rate in middle-aged and elderly populations: evidence based on the China Health and Retirement Longitudinal Study BMJ Open |
| title | Association of uric acid with the decline in estimated glomerular filtration rate in middle-aged and elderly populations: evidence based on the China Health and Retirement Longitudinal Study |
| title_full | Association of uric acid with the decline in estimated glomerular filtration rate in middle-aged and elderly populations: evidence based on the China Health and Retirement Longitudinal Study |
| title_fullStr | Association of uric acid with the decline in estimated glomerular filtration rate in middle-aged and elderly populations: evidence based on the China Health and Retirement Longitudinal Study |
| title_full_unstemmed | Association of uric acid with the decline in estimated glomerular filtration rate in middle-aged and elderly populations: evidence based on the China Health and Retirement Longitudinal Study |
| title_short | Association of uric acid with the decline in estimated glomerular filtration rate in middle-aged and elderly populations: evidence based on the China Health and Retirement Longitudinal Study |
| title_sort | association of uric acid with the decline in estimated glomerular filtration rate in middle aged and elderly populations evidence based on the china health and retirement longitudinal study |
| url | https://bmjopen.bmj.com/content/13/5/e071771.full |
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