Engineering strategies for apoptotic bodies
Abstract Extracellular vesicles (EVs) are lipid bilayer vesicles containing proteins, lipids, nucleic acids, and metabolites secreted by cells under various physiological and pathological conditions that mediate intercellular communication. The main types of EVs include exosomes, microvesicles, and...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2024-09-01
|
| Series: | Smart Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/SMMD.20240005 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850262001010343936 |
|---|---|
| author | Zheyuan Hu Shutong Qian Qiuyu Zhao Bolun Lu Qian Lu Yuhuan Wang Liucheng Zhang Xiyuan Mao Danru Wang Wenguo Cui Xiaoming Sun |
| author_facet | Zheyuan Hu Shutong Qian Qiuyu Zhao Bolun Lu Qian Lu Yuhuan Wang Liucheng Zhang Xiyuan Mao Danru Wang Wenguo Cui Xiaoming Sun |
| author_sort | Zheyuan Hu |
| collection | DOAJ |
| description | Abstract Extracellular vesicles (EVs) are lipid bilayer vesicles containing proteins, lipids, nucleic acids, and metabolites secreted by cells under various physiological and pathological conditions that mediate intercellular communication. The main types of EVs include exosomes, microvesicles, and apoptotic bodies (ABs). ABs are vesicles released during the terminal stages of cellular apoptosis, enriched with diverse biological entities and characterized by distinct morphological features. As a result, ABs possess great potential in fields like disease diagnosis, immunotherapy, regenerative therapy, and drug delivery due to their specificity, targeting capacity, and biocompatibility. However, their therapeutic efficacy is notably heterogeneous, and an overdose can lead to side effects such as accumulation in the liver, spleen, lungs, and gastrointestinal system. Through bioengineering, the properties of ABs can be optimized to enhance drug‐loading efficiency, targeting precision, and multifunctionality for clinical implementations. This review focuses on strategies such as transfection, sonication, electroporation, surface engineering, and integration with biomaterials to enable ABs to load cargoes and enhance targeting, providing insights into the engineering of ABs. |
| format | Article |
| id | doaj-art-f29f33d2d51248c2bed5512fcc4ee1e8 |
| institution | OA Journals |
| issn | 2751-1871 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Smart Medicine |
| spelling | doaj-art-f29f33d2d51248c2bed5512fcc4ee1e82025-08-20T01:55:16ZengWiley-VCHSmart Medicine2751-18712024-09-0133n/an/a10.1002/SMMD.20240005Engineering strategies for apoptotic bodiesZheyuan Hu0Shutong Qian1Qiuyu Zhao2Bolun Lu3Qian Lu4Yuhuan Wang5Liucheng Zhang6Xiyuan Mao7Danru Wang8Wenguo Cui9Xiaoming Sun10Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaAbstract Extracellular vesicles (EVs) are lipid bilayer vesicles containing proteins, lipids, nucleic acids, and metabolites secreted by cells under various physiological and pathological conditions that mediate intercellular communication. The main types of EVs include exosomes, microvesicles, and apoptotic bodies (ABs). ABs are vesicles released during the terminal stages of cellular apoptosis, enriched with diverse biological entities and characterized by distinct morphological features. As a result, ABs possess great potential in fields like disease diagnosis, immunotherapy, regenerative therapy, and drug delivery due to their specificity, targeting capacity, and biocompatibility. However, their therapeutic efficacy is notably heterogeneous, and an overdose can lead to side effects such as accumulation in the liver, spleen, lungs, and gastrointestinal system. Through bioengineering, the properties of ABs can be optimized to enhance drug‐loading efficiency, targeting precision, and multifunctionality for clinical implementations. This review focuses on strategies such as transfection, sonication, electroporation, surface engineering, and integration with biomaterials to enable ABs to load cargoes and enhance targeting, providing insights into the engineering of ABs.https://doi.org/10.1002/SMMD.20240005apoptotic bodiesengineeringextracellular vesicles |
| spellingShingle | Zheyuan Hu Shutong Qian Qiuyu Zhao Bolun Lu Qian Lu Yuhuan Wang Liucheng Zhang Xiyuan Mao Danru Wang Wenguo Cui Xiaoming Sun Engineering strategies for apoptotic bodies Smart Medicine apoptotic bodies engineering extracellular vesicles |
| title | Engineering strategies for apoptotic bodies |
| title_full | Engineering strategies for apoptotic bodies |
| title_fullStr | Engineering strategies for apoptotic bodies |
| title_full_unstemmed | Engineering strategies for apoptotic bodies |
| title_short | Engineering strategies for apoptotic bodies |
| title_sort | engineering strategies for apoptotic bodies |
| topic | apoptotic bodies engineering extracellular vesicles |
| url | https://doi.org/10.1002/SMMD.20240005 |
| work_keys_str_mv | AT zheyuanhu engineeringstrategiesforapoptoticbodies AT shutongqian engineeringstrategiesforapoptoticbodies AT qiuyuzhao engineeringstrategiesforapoptoticbodies AT bolunlu engineeringstrategiesforapoptoticbodies AT qianlu engineeringstrategiesforapoptoticbodies AT yuhuanwang engineeringstrategiesforapoptoticbodies AT liuchengzhang engineeringstrategiesforapoptoticbodies AT xiyuanmao engineeringstrategiesforapoptoticbodies AT danruwang engineeringstrategiesforapoptoticbodies AT wenguocui engineeringstrategiesforapoptoticbodies AT xiaomingsun engineeringstrategiesforapoptoticbodies |