Prediction and Risk Factors for Prognosis of Cirrhotic Patients with Hepatic Encephalopathy
Background and Aims. Hepatic encephalopathy (HE) is characterized by recurrence and poor quality of life. Acute-on-chronic liver failure (ACLF) mainly occurs in patients with chronic liver diseases and often presents with HE. Several predictive models have been proposed to predict the outcomes of th...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/5623601 |
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| author | Ying Peng Qinglin Wei Yun Liu Zhenyu Wu Hongjia Zhang Hongbo Wu Jin Chai |
| author_facet | Ying Peng Qinglin Wei Yun Liu Zhenyu Wu Hongjia Zhang Hongbo Wu Jin Chai |
| author_sort | Ying Peng |
| collection | DOAJ |
| description | Background and Aims. Hepatic encephalopathy (HE) is characterized by recurrence and poor quality of life. Acute-on-chronic liver failure (ACLF) mainly occurs in patients with chronic liver diseases and often presents with HE. Several predictive models have been proposed to predict the outcomes of these patients. Our study is aimed at identifying associated risk factors and the prognostic accuracies of predictive models in HE patients with or without ACLF. Methods. Patients with liver cirrhosis were retrospectively enrolled. Risk factors were evaluated by multivariate regression analyses. The predictive capabilities of models were calculated using the receiver operating characteristic (ROC) curve analyses and compared by the DeLong tests. Outcomes were defined as in-hospital mortality, HE severity, and ACLF occurrence. Results. In multivariate regression analyses, serum biomarkers neutrophil and total bilirubin (TBIL) were independently correlated with in-hospital death. Alanine aminotransferase (ALT) and blood urea nitrogen (BUN) were independent serum biomarkers associated with HE severity. Hemoglobin, TBIL, BUN, and international normalized ratio (INR) were significant indicators associated with ACLF incidence. For prediction of in-hospital mortality, Child-Pugh was superior to the others in the whole patients, while NLR showed the best capability in the ACLF group. Conclusion. In cirrhotic patients present with HE, BUN is a risk factor associated with HE severity and ACLF incidence. Child-Pugh and NLR scores may be effective prognosticators in patients with HE. |
| format | Article |
| id | doaj-art-f293f4c151fe41609a4b449ed5aae586 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-f293f4c151fe41609a4b449ed5aae5862025-02-03T01:25:18ZengWileyGastroenterology Research and Practice1687-61211687-630X2021-01-01202110.1155/2021/56236015623601Prediction and Risk Factors for Prognosis of Cirrhotic Patients with Hepatic EncephalopathyYing Peng0Qinglin Wei1Yun Liu2Zhenyu Wu3Hongjia Zhang4Hongbo Wu5Jin Chai6Cholestatic Liver Diseases Center and Department of Gastroenterology, The First Affiliated Hospital of Army Medical University, Chongqing, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Army Medical University, Chongqing, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Army Medical University, Chongqing, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Army Medical University, Chongqing, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Army Medical University, Chongqing, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Army Medical University, Chongqing, ChinaCholestatic Liver Diseases Center and Department of Gastroenterology, The First Affiliated Hospital of Army Medical University, Chongqing, ChinaBackground and Aims. Hepatic encephalopathy (HE) is characterized by recurrence and poor quality of life. Acute-on-chronic liver failure (ACLF) mainly occurs in patients with chronic liver diseases and often presents with HE. Several predictive models have been proposed to predict the outcomes of these patients. Our study is aimed at identifying associated risk factors and the prognostic accuracies of predictive models in HE patients with or without ACLF. Methods. Patients with liver cirrhosis were retrospectively enrolled. Risk factors were evaluated by multivariate regression analyses. The predictive capabilities of models were calculated using the receiver operating characteristic (ROC) curve analyses and compared by the DeLong tests. Outcomes were defined as in-hospital mortality, HE severity, and ACLF occurrence. Results. In multivariate regression analyses, serum biomarkers neutrophil and total bilirubin (TBIL) were independently correlated with in-hospital death. Alanine aminotransferase (ALT) and blood urea nitrogen (BUN) were independent serum biomarkers associated with HE severity. Hemoglobin, TBIL, BUN, and international normalized ratio (INR) were significant indicators associated with ACLF incidence. For prediction of in-hospital mortality, Child-Pugh was superior to the others in the whole patients, while NLR showed the best capability in the ACLF group. Conclusion. In cirrhotic patients present with HE, BUN is a risk factor associated with HE severity and ACLF incidence. Child-Pugh and NLR scores may be effective prognosticators in patients with HE.http://dx.doi.org/10.1155/2021/5623601 |
| spellingShingle | Ying Peng Qinglin Wei Yun Liu Zhenyu Wu Hongjia Zhang Hongbo Wu Jin Chai Prediction and Risk Factors for Prognosis of Cirrhotic Patients with Hepatic Encephalopathy Gastroenterology Research and Practice |
| title | Prediction and Risk Factors for Prognosis of Cirrhotic Patients with Hepatic Encephalopathy |
| title_full | Prediction and Risk Factors for Prognosis of Cirrhotic Patients with Hepatic Encephalopathy |
| title_fullStr | Prediction and Risk Factors for Prognosis of Cirrhotic Patients with Hepatic Encephalopathy |
| title_full_unstemmed | Prediction and Risk Factors for Prognosis of Cirrhotic Patients with Hepatic Encephalopathy |
| title_short | Prediction and Risk Factors for Prognosis of Cirrhotic Patients with Hepatic Encephalopathy |
| title_sort | prediction and risk factors for prognosis of cirrhotic patients with hepatic encephalopathy |
| url | http://dx.doi.org/10.1155/2021/5623601 |
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