EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY AND ULCEROGENIC LIABILITY OF 5-(3-CHLORO-1-BENZOTHIEN -2-YL)-4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL
The aim of this study was to evaluate the anti-inflammatory and the ulcerogenic activity of 5-(3-chloro-1-benzothien -2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol. The anti-inflammatory effect of the compound was determined by comparing it with a standard drug (naproxen). The anti-inflammatory effects w...
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| Format: | Article |
| Language: | English |
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College of Veterinary Medicine, University of Basrah, Iraq
2012-06-01
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| Series: | Basrah Journal of Veterinary Research |
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| Online Access: | https://bjvr.uobasrah.edu.iq/article_54766_e11c89ececc4fdb08b29404f479f57a8.pdf |
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| _version_ | 1850135299308388352 |
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| author | Mazin N. Mousa |
| author_facet | Mazin N. Mousa |
| author_sort | Mazin N. Mousa |
| collection | DOAJ |
| description | The aim of this study was to evaluate the anti-inflammatory and the ulcerogenic activity of 5-(3-chloro-1-benzothien -2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol. The anti-inflammatory effect of the compound was determined by comparing it with a standard drug (naproxen). The anti-inflammatory effects were studied by using carrageenan-induced paw edema method and Cotton pellet induced granuloma in rats and the ulcerogenic liability was assessed and compared with a standard drug. The results showed that the compound had an obvious anti-inflammatory effect and the activity is comparable to that of the standard drug with less ulcerogenic effects. |
| format | Article |
| id | doaj-art-f293a41b39934a7e954c704f89fa59f5 |
| institution | OA Journals |
| issn | 1813-8497 2410-8456 |
| language | English |
| publishDate | 2012-06-01 |
| publisher | College of Veterinary Medicine, University of Basrah, Iraq |
| record_format | Article |
| series | Basrah Journal of Veterinary Research |
| spelling | doaj-art-f293a41b39934a7e954c704f89fa59f52025-08-20T02:31:28ZengCollege of Veterinary Medicine, University of Basrah, IraqBasrah Journal of Veterinary Research1813-84972410-84562012-06-0111112212710.33762/bvetr.2012.5476654766EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY AND ULCEROGENIC LIABILITY OF 5-(3-CHLORO-1-BENZOTHIEN -2-YL)-4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOLMazin N. MousaThe aim of this study was to evaluate the anti-inflammatory and the ulcerogenic activity of 5-(3-chloro-1-benzothien -2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol. The anti-inflammatory effect of the compound was determined by comparing it with a standard drug (naproxen). The anti-inflammatory effects were studied by using carrageenan-induced paw edema method and Cotton pellet induced granuloma in rats and the ulcerogenic liability was assessed and compared with a standard drug. The results showed that the compound had an obvious anti-inflammatory effect and the activity is comparable to that of the standard drug with less ulcerogenic effects.https://bjvr.uobasrah.edu.iq/article_54766_e11c89ececc4fdb08b29404f479f57a8.pdfanti inflammatorytriazoleulcer |
| spellingShingle | Mazin N. Mousa EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY AND ULCEROGENIC LIABILITY OF 5-(3-CHLORO-1-BENZOTHIEN -2-YL)-4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL Basrah Journal of Veterinary Research anti inflammatory triazole ulcer |
| title | EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY AND ULCEROGENIC LIABILITY OF 5-(3-CHLORO-1-BENZOTHIEN -2-YL)-4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL |
| title_full | EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY AND ULCEROGENIC LIABILITY OF 5-(3-CHLORO-1-BENZOTHIEN -2-YL)-4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL |
| title_fullStr | EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY AND ULCEROGENIC LIABILITY OF 5-(3-CHLORO-1-BENZOTHIEN -2-YL)-4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL |
| title_full_unstemmed | EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY AND ULCEROGENIC LIABILITY OF 5-(3-CHLORO-1-BENZOTHIEN -2-YL)-4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL |
| title_short | EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY AND ULCEROGENIC LIABILITY OF 5-(3-CHLORO-1-BENZOTHIEN -2-YL)-4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL |
| title_sort | evaluation of the anti inflammatory activity and ulcerogenic liability of 5 3 chloro 1 benzothien 2 yl 4 phenyl 4h 1 2 4 triazole 3 thiol |
| topic | anti inflammatory triazole ulcer |
| url | https://bjvr.uobasrah.edu.iq/article_54766_e11c89ececc4fdb08b29404f479f57a8.pdf |
| work_keys_str_mv | AT mazinnmousa evaluationoftheantiinflammatoryactivityandulcerogenicliabilityof53chloro1benzothien2yl4phenyl4h124triazole3thiol |