Syntheses of Some 3,5-Diaryl-4H-1,2,4-triazole Derivatives and their Antifungal Activity
Syntheses of a series of 3, 5-diaryl-4H-1, 2, 4-triazole derivatives are described. In this present work, 4-amino-3-phenyl-5-p-tolyl-4H-1,2,4-triazole(1) was converted to N,N’-bis[3-phenyl-5-p-tolyl-4H-1,2,4-triazolyl]-1,4-xylenediimine(2) and 3-Phenyl-5-p-tolyl-4-[4-methyl benzylidenamino]-4H-1,2,4...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
|
| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2009/925964 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Syntheses of a series of 3, 5-diaryl-4H-1, 2, 4-triazole derivatives are described. In this present work, 4-amino-3-phenyl-5-p-tolyl-4H-1,2,4-triazole(1) was converted to N,N’-bis[3-phenyl-5-p-tolyl-4H-1,2,4-triazolyl]-1,4-xylenediimine(2) and 3-Phenyl-5-p-tolyl-4-[4-methyl benzylidenamino]-4H-1,2,4-triazole (3) in good yields by treatment with aldehydes OHC-C6H4-CHO and Ar-CHO respectively. The compounds N,N’-bis [3-phenyl-5-p-tolyl-4H-1,2,4-triazolyl]-1,4-xylenediimine (2) and 3-phenyl-5-p-tolyl-4-[4-methyl benzylidenamino]-4H-1,2,4-triazole (3) were reduced with NaBH4 to afford the corresponding compounds N,N’-bis [3-phenyl-5--tolyl-4H-1,2,4-triazolyl]-1,4-xylenediamine (4) and 3-phenyl-5-p-tolyl-4-[4-methyl benzylamino]-4H-1,2,4-triazole (5) respectively. The newly synthesized compounds were characterized by spectral and elemental analyses. All the synthesized compounds were tested for their antifungal activity against P.oryzae, B. cinerea, A. niger, C. albicans and T. rubrum. |
|---|---|
| ISSN: | 0973-4945 2090-9810 |