Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer
Biliary tract cancer (BTC) is a rare cancer and is associated with a poor prognosis. To understand the genetic characteristics of BTC, we analyzed whole-exome sequencing data and identified somatic mutations in patients with BTC. Tumors and matched blood or normal samples were obtained from seven pa...
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| Format: | Article |
| Language: | English |
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BioMed Central
2018-12-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gi-2018-16-4-e35.pdf |
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| author | Kyong-Ah Yoon Sang Myung Woo Yun-Hee Kim Sun-Young Kong Sung-Sik Han Sang-Jae Park Woo Jin Lee |
| author_facet | Kyong-Ah Yoon Sang Myung Woo Yun-Hee Kim Sun-Young Kong Sung-Sik Han Sang-Jae Park Woo Jin Lee |
| author_sort | Kyong-Ah Yoon |
| collection | DOAJ |
| description | Biliary tract cancer (BTC) is a rare cancer and is associated with a poor prognosis. To understand the genetic characteristics of BTC, we analyzed whole-exome sequencing data and identified somatic mutations in patients with BTC. Tumors and matched blood or normal samples were obtained from seven patients with cholangiocarcinoma who underwent surgical resection. We discovered inactivating mutations of tumor suppressor genes, including APC, TP53, and ARID1A, in three patients. Activating mutations of KRAS and NRAS were also identified. Our analyses identified somatic mutations in Korean patients with BTC. |
| format | Article |
| id | doaj-art-f27e384e653c4a8eb8732cb810502274 |
| institution | Kabale University |
| issn | 2234-0742 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-f27e384e653c4a8eb8732cb8105022742025-02-02T02:30:09ZengBioMed CentralGenomics & Informatics2234-07422018-12-0116410.5808/GI.2018.16.4.e35537Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract CancerKyong-Ah Yoon0Sang Myung Woo1Yun-Hee Kim2Sun-Young Kong3Sung-Sik Han4Sang-Jae Park5Woo Jin Lee6 College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea Center for Liver Cancer, National Cancer Center, Goyang 10408, Korea Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang 10408, Korea Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang 10408, Korea Center for Liver Cancer, National Cancer Center, Goyang 10408, Korea Center for Liver Cancer, National Cancer Center, Goyang 10408, Korea Center for Liver Cancer, National Cancer Center, Goyang 10408, KoreaBiliary tract cancer (BTC) is a rare cancer and is associated with a poor prognosis. To understand the genetic characteristics of BTC, we analyzed whole-exome sequencing data and identified somatic mutations in patients with BTC. Tumors and matched blood or normal samples were obtained from seven patients with cholangiocarcinoma who underwent surgical resection. We discovered inactivating mutations of tumor suppressor genes, including APC, TP53, and ARID1A, in three patients. Activating mutations of KRAS and NRAS were also identified. Our analyses identified somatic mutations in Korean patients with BTC.http://genominfo.org/upload/pdf/gi-2018-16-4-e35.pdfbiliary tract neoplasmscholangiocarcinomasomatic mutationswhole-exome sequencing |
| spellingShingle | Kyong-Ah Yoon Sang Myung Woo Yun-Hee Kim Sun-Young Kong Sung-Sik Han Sang-Jae Park Woo Jin Lee Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer Genomics & Informatics biliary tract neoplasms cholangiocarcinoma somatic mutations whole-exome sequencing |
| title | Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer |
| title_full | Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer |
| title_fullStr | Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer |
| title_full_unstemmed | Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer |
| title_short | Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer |
| title_sort | somatic mutations from whole exome sequencing analysis of the patients with biliary tract cancer |
| topic | biliary tract neoplasms cholangiocarcinoma somatic mutations whole-exome sequencing |
| url | http://genominfo.org/upload/pdf/gi-2018-16-4-e35.pdf |
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