Successful Oocyte Retrieval, Fertilization, and Clinical Pregnancy with Low Serum β-hCG on the Day of Oocyte Collection: A Reappraisal of the Definition of the Empty Follicle Syndrome
Objective. To describe a case of successful oocyte retrieval, fertilization and clinical pregnancy despite very low β-hCG level, twelve hours after ovulation trigger. Design. Case report. Setting. Academic medical center. Patient. A 38-year-old patient inadvertently administered 2,000 IU hCG for fin...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2020/9210651 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566035612434432 |
|---|---|
| author | Nicole A. Van De Velde Charalampos Chatzicharalampous Awoniyi O. Awonuga |
| author_facet | Nicole A. Van De Velde Charalampos Chatzicharalampous Awoniyi O. Awonuga |
| author_sort | Nicole A. Van De Velde |
| collection | DOAJ |
| description | Objective. To describe a case of successful oocyte retrieval, fertilization and clinical pregnancy despite very low β-hCG level, twelve hours after ovulation trigger. Design. Case report. Setting. Academic medical center. Patient. A 38-year-old patient inadvertently administered 2,000 IU hCG for final oocyte maturation; serum hCG twelve hours later was 16 IU/L. Interventions. Effort to obtain and administer a booster dose of hCG over the next twenty-seven hours failed. Main Outcome. Successful oocyte retrieval. Results. Fourteen oocytes were retrieved of which twelve were in metaphase II and nine fertilized after intracytoplasmic sperm injection (ICSI). Of these, eight embryos survived to day 5 and were subjected to preimplantation genetic screening (PGS) by comparative genomic hybridization (CGH). Results were available the next day, three of the embryos were euploid and one was transferred on day 6. Pregnancy was confirmed twelve days later and currently the patient has an ongoing singleton intrauterine pregnancy. Conclusion. Reproductive Endocrinology and Infertility specialists should be aware that final oocyte maturation could occur following injection of a lower dose of hCG with excellent fertilization rate and embryo development. |
| format | Article |
| id | doaj-art-f2737be5c0714f3da9b336e5b3f9ee7e |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-f2737be5c0714f3da9b336e5b3f9ee7e2025-02-03T01:05:18ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922020-01-01202010.1155/2020/92106519210651Successful Oocyte Retrieval, Fertilization, and Clinical Pregnancy with Low Serum β-hCG on the Day of Oocyte Collection: A Reappraisal of the Definition of the Empty Follicle SyndromeNicole A. Van De Velde0Charalampos Chatzicharalampous1Awoniyi O. Awonuga2Resident in Obstetrics and Gynecology, University of Tennessee Health Science Center, USADivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, NYU School of Medicine, NYU Langone Reproductive Specialists of New York, USADivision of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, USAObjective. To describe a case of successful oocyte retrieval, fertilization and clinical pregnancy despite very low β-hCG level, twelve hours after ovulation trigger. Design. Case report. Setting. Academic medical center. Patient. A 38-year-old patient inadvertently administered 2,000 IU hCG for final oocyte maturation; serum hCG twelve hours later was 16 IU/L. Interventions. Effort to obtain and administer a booster dose of hCG over the next twenty-seven hours failed. Main Outcome. Successful oocyte retrieval. Results. Fourteen oocytes were retrieved of which twelve were in metaphase II and nine fertilized after intracytoplasmic sperm injection (ICSI). Of these, eight embryos survived to day 5 and were subjected to preimplantation genetic screening (PGS) by comparative genomic hybridization (CGH). Results were available the next day, three of the embryos were euploid and one was transferred on day 6. Pregnancy was confirmed twelve days later and currently the patient has an ongoing singleton intrauterine pregnancy. Conclusion. Reproductive Endocrinology and Infertility specialists should be aware that final oocyte maturation could occur following injection of a lower dose of hCG with excellent fertilization rate and embryo development.http://dx.doi.org/10.1155/2020/9210651 |
| spellingShingle | Nicole A. Van De Velde Charalampos Chatzicharalampous Awoniyi O. Awonuga Successful Oocyte Retrieval, Fertilization, and Clinical Pregnancy with Low Serum β-hCG on the Day of Oocyte Collection: A Reappraisal of the Definition of the Empty Follicle Syndrome Case Reports in Obstetrics and Gynecology |
| title | Successful Oocyte Retrieval, Fertilization, and Clinical Pregnancy with Low Serum β-hCG on the Day of Oocyte Collection: A Reappraisal of the Definition of the Empty Follicle Syndrome |
| title_full | Successful Oocyte Retrieval, Fertilization, and Clinical Pregnancy with Low Serum β-hCG on the Day of Oocyte Collection: A Reappraisal of the Definition of the Empty Follicle Syndrome |
| title_fullStr | Successful Oocyte Retrieval, Fertilization, and Clinical Pregnancy with Low Serum β-hCG on the Day of Oocyte Collection: A Reappraisal of the Definition of the Empty Follicle Syndrome |
| title_full_unstemmed | Successful Oocyte Retrieval, Fertilization, and Clinical Pregnancy with Low Serum β-hCG on the Day of Oocyte Collection: A Reappraisal of the Definition of the Empty Follicle Syndrome |
| title_short | Successful Oocyte Retrieval, Fertilization, and Clinical Pregnancy with Low Serum β-hCG on the Day of Oocyte Collection: A Reappraisal of the Definition of the Empty Follicle Syndrome |
| title_sort | successful oocyte retrieval fertilization and clinical pregnancy with low serum β hcg on the day of oocyte collection a reappraisal of the definition of the empty follicle syndrome |
| url | http://dx.doi.org/10.1155/2020/9210651 |
| work_keys_str_mv | AT nicoleavandevelde successfuloocyteretrievalfertilizationandclinicalpregnancywithlowserumbhcgonthedayofoocytecollectionareappraisalofthedefinitionoftheemptyfolliclesyndrome AT charalamposchatzicharalampous successfuloocyteretrievalfertilizationandclinicalpregnancywithlowserumbhcgonthedayofoocytecollectionareappraisalofthedefinitionoftheemptyfolliclesyndrome AT awoniyioawonuga successfuloocyteretrievalfertilizationandclinicalpregnancywithlowserumbhcgonthedayofoocytecollectionareappraisalofthedefinitionoftheemptyfolliclesyndrome |