Assessment of Postresuscitation Volume Status by Bioimpedance Analysis in Patients with Sepsis in the Intensive Care Unit: A Pilot Observational Study
Background. Bioimpedance analysis (BIA) is a novel method of assessing a patient’s volume status. Objective. We sought to determine the feasibility of using vector length (VL), derived from bioimpedance analysis (BIA), in the assessment of postresuscitation volume status in intensive care unit (ICU)...
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| Format: | Article |
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Wiley
2016-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2016/8671742 |
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| author | Bram Rochwerg Jason H. Cheung Christine M. Ribic Faraz Lalji France J. Clarke Susheel Gantareddy Nischal Ranganath Aziz Walele Ellen McDonald Maureen O. Meade Deborah J. Cook Trevor T. Wilkieson Catherine M. Clase Peter J. Margetts Azim S. Gangji |
| author_facet | Bram Rochwerg Jason H. Cheung Christine M. Ribic Faraz Lalji France J. Clarke Susheel Gantareddy Nischal Ranganath Aziz Walele Ellen McDonald Maureen O. Meade Deborah J. Cook Trevor T. Wilkieson Catherine M. Clase Peter J. Margetts Azim S. Gangji |
| author_sort | Bram Rochwerg |
| collection | DOAJ |
| description | Background. Bioimpedance analysis (BIA) is a novel method of assessing a patient’s volume status. Objective. We sought to determine the feasibility of using vector length (VL), derived from bioimpedance analysis (BIA), in the assessment of postresuscitation volume status in intensive care unit (ICU) patients with sepsis. Method. This was a prospective observational single-center study. Our primary outcome was feasibility. Secondary clinical outcomes included ventilator status and acute kidney injury. Proof of concept was sought by correlating baseline VL measurements with other known measures of volume status. Results. BIA was feasible to perform in the ICU. We screened 655 patients, identified 78 eligible patients, and approached 64 for consent. We enrolled 60 patients (consent rate of 93.8%) over 12 months. For each 50-unit increase in VL, there was an associated 22% increase in the probability of not requiring invasive mechanical ventilation (IMV) (p=0.13). Baseline VL correlated with other measures of volume expansion including serum pro-BNP levels, peripheral edema, and central venous pressure (CVP). Conclusion. It is feasible to use BIA to predict postresuscitation volume status and patient-important outcomes in septic ICU patients. Trial Registration. This trial is registered with clinicaltrials.gov NCT01379404 registered on June 7, 2011. |
| format | Article |
| id | doaj-art-f26bdf9f644149eda9a81463d8700434 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-f26bdf9f644149eda9a81463d87004342025-02-03T05:45:31ZengWileyCanadian Respiratory Journal1198-22411916-72452016-01-01201610.1155/2016/86717428671742Assessment of Postresuscitation Volume Status by Bioimpedance Analysis in Patients with Sepsis in the Intensive Care Unit: A Pilot Observational StudyBram Rochwerg0Jason H. Cheung1Christine M. Ribic2Faraz Lalji3France J. Clarke4Susheel Gantareddy5Nischal Ranganath6Aziz Walele7Ellen McDonald8Maureen O. Meade9Deborah J. Cook10Trevor T. Wilkieson11Catherine M. Clase12Peter J. Margetts13Azim S. Gangji14Department of Medicine, McMaster University, Hamilton, ON, CanadaDepartment of Medicine, McMaster University, Hamilton, ON, CanadaDepartment of Medicine, McMaster University, Hamilton, ON, CanadaDivision of Nephrology, St. Joseph’s Healthcare Hamilton, Hamilton, ON, CanadaDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, CanadaDepartment of Family Medicine, Northern Ontario School of Medicine, Sudbury, ON, CanadaDepartment of Medicine, McMaster University, Hamilton, ON, CanadaBrampton Civic Hospital, Brampton, ON, CanadaDepartment of Medicine, McMaster University, Hamilton, ON, CanadaDepartment of Medicine, McMaster University, Hamilton, ON, CanadaDepartment of Medicine, McMaster University, Hamilton, ON, CanadaDivision of Nephrology, St. Joseph’s Healthcare Hamilton, Hamilton, ON, CanadaDepartment of Medicine, McMaster University, Hamilton, ON, CanadaDepartment of Medicine, McMaster University, Hamilton, ON, CanadaDepartment of Medicine, McMaster University, Hamilton, ON, CanadaBackground. Bioimpedance analysis (BIA) is a novel method of assessing a patient’s volume status. Objective. We sought to determine the feasibility of using vector length (VL), derived from bioimpedance analysis (BIA), in the assessment of postresuscitation volume status in intensive care unit (ICU) patients with sepsis. Method. This was a prospective observational single-center study. Our primary outcome was feasibility. Secondary clinical outcomes included ventilator status and acute kidney injury. Proof of concept was sought by correlating baseline VL measurements with other known measures of volume status. Results. BIA was feasible to perform in the ICU. We screened 655 patients, identified 78 eligible patients, and approached 64 for consent. We enrolled 60 patients (consent rate of 93.8%) over 12 months. For each 50-unit increase in VL, there was an associated 22% increase in the probability of not requiring invasive mechanical ventilation (IMV) (p=0.13). Baseline VL correlated with other measures of volume expansion including serum pro-BNP levels, peripheral edema, and central venous pressure (CVP). Conclusion. It is feasible to use BIA to predict postresuscitation volume status and patient-important outcomes in septic ICU patients. Trial Registration. This trial is registered with clinicaltrials.gov NCT01379404 registered on June 7, 2011.http://dx.doi.org/10.1155/2016/8671742 |
| spellingShingle | Bram Rochwerg Jason H. Cheung Christine M. Ribic Faraz Lalji France J. Clarke Susheel Gantareddy Nischal Ranganath Aziz Walele Ellen McDonald Maureen O. Meade Deborah J. Cook Trevor T. Wilkieson Catherine M. Clase Peter J. Margetts Azim S. Gangji Assessment of Postresuscitation Volume Status by Bioimpedance Analysis in Patients with Sepsis in the Intensive Care Unit: A Pilot Observational Study Canadian Respiratory Journal |
| title | Assessment of Postresuscitation Volume Status by Bioimpedance Analysis in Patients with Sepsis in the Intensive Care Unit: A Pilot Observational Study |
| title_full | Assessment of Postresuscitation Volume Status by Bioimpedance Analysis in Patients with Sepsis in the Intensive Care Unit: A Pilot Observational Study |
| title_fullStr | Assessment of Postresuscitation Volume Status by Bioimpedance Analysis in Patients with Sepsis in the Intensive Care Unit: A Pilot Observational Study |
| title_full_unstemmed | Assessment of Postresuscitation Volume Status by Bioimpedance Analysis in Patients with Sepsis in the Intensive Care Unit: A Pilot Observational Study |
| title_short | Assessment of Postresuscitation Volume Status by Bioimpedance Analysis in Patients with Sepsis in the Intensive Care Unit: A Pilot Observational Study |
| title_sort | assessment of postresuscitation volume status by bioimpedance analysis in patients with sepsis in the intensive care unit a pilot observational study |
| url | http://dx.doi.org/10.1155/2016/8671742 |
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