The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review
Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/9128754 |
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| author | Rafael Martins de Morais Alaor Barra Sobrinho Calliandra Maria de Souza Silva Jamila Reis de Oliveira Izabel Cristina Rodrigues da Silva Otávio de Toledo Nóbrega |
| author_facet | Rafael Martins de Morais Alaor Barra Sobrinho Calliandra Maria de Souza Silva Jamila Reis de Oliveira Izabel Cristina Rodrigues da Silva Otávio de Toledo Nóbrega |
| author_sort | Rafael Martins de Morais |
| collection | DOAJ |
| description | Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80–90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper’s objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer. |
| format | Article |
| id | doaj-art-f26b6b82cb26491a9e404d4fbeac4a32 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-f26b6b82cb26491a9e404d4fbeac4a322025-02-03T05:52:14ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/91287549128754The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic ReviewRafael Martins de Morais0Alaor Barra Sobrinho1Calliandra Maria de Souza Silva2Jamila Reis de Oliveira3Izabel Cristina Rodrigues da Silva4Otávio de Toledo Nóbrega5Post-Graduate in Medical Sciences Program, University of Brasília, Brasília, DF, BrazilImagens Médicas de Brasília, Brasília, DF, BrazilInstitute of Biological Sciences, University of Brasília, Brasília, DF, BrazilFaculty of Ceilândia, University of Brasília, Brasília, DF, BrazilFaculty of Ceilândia, University of Brasília, Brasília, DF, BrazilFaculty of Ceilândia, University of Brasília, Brasília, DF, BrazilPapillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80–90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper’s objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer.http://dx.doi.org/10.1155/2018/9128754 |
| spellingShingle | Rafael Martins de Morais Alaor Barra Sobrinho Calliandra Maria de Souza Silva Jamila Reis de Oliveira Izabel Cristina Rodrigues da Silva Otávio de Toledo Nóbrega The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review International Journal of Endocrinology |
| title | The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review |
| title_full | The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review |
| title_fullStr | The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review |
| title_full_unstemmed | The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review |
| title_short | The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review |
| title_sort | role of the nis slc5a5 gene in papillary thyroid cancer a systematic review |
| url | http://dx.doi.org/10.1155/2018/9128754 |
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