Individual participant data (IPD) meta-analysis: An introduction – Narrative review
Systematic reviews and meta-analyses (MA) are accepted modalities for evidence synthesis in evidence-based medicine. However, as MA uses aggregate data that includes averaging patient characteristics and pooled effect estimates, it has limitations when considering personalised medicine. In contrast,...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
|
| Series: | Indian Journal of Anaesthesia |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ija.ija_1187_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087442313707520 |
|---|---|
| author | Ekta Rai Vibhavari Naik Aparna Williams Mohan S. Kamath |
| author_facet | Ekta Rai Vibhavari Naik Aparna Williams Mohan S. Kamath |
| author_sort | Ekta Rai |
| collection | DOAJ |
| description | Systematic reviews and meta-analyses (MA) are accepted modalities for evidence synthesis in evidence-based medicine. However, as MA uses aggregate data that includes averaging patient characteristics and pooled effect estimates, it has limitations when considering personalised medicine. In contrast, individual participant data meta-analysis (IPD-MA) includes and segregates individual patient data to study new outcomes, identify outcome predictors, and analyse multiple covariate effects on treatments. IPD-MA requires data from multiple investigators, review board approvals, clear communication with collaborators, and statistical recalculation of cumulative data. IPD-MA can be performed as a single-stage process where data from all included studies is pooled and reanalysed or as a two-stage process where additionally the data from individual studies is re-analysed before being pooled. This review aims to orient clinicians about IPD-MA, including the process of performing it, comparing it with other types of meta-analyses and considering the potential barriers in conducting it. |
| format | Article |
| id | doaj-art-f264a70de1ee422e88419fb2f06585d7 |
| institution | Kabale University |
| issn | 0019-5049 0976-2817 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Anaesthesia |
| spelling | doaj-art-f264a70de1ee422e88419fb2f06585d72025-02-06T05:26:09ZengWolters Kluwer Medknow PublicationsIndian Journal of Anaesthesia0019-50490976-28172025-01-0169115316010.4103/ija.ija_1187_24Individual participant data (IPD) meta-analysis: An introduction – Narrative reviewEkta RaiVibhavari NaikAparna WilliamsMohan S. KamathSystematic reviews and meta-analyses (MA) are accepted modalities for evidence synthesis in evidence-based medicine. However, as MA uses aggregate data that includes averaging patient characteristics and pooled effect estimates, it has limitations when considering personalised medicine. In contrast, individual participant data meta-analysis (IPD-MA) includes and segregates individual patient data to study new outcomes, identify outcome predictors, and analyse multiple covariate effects on treatments. IPD-MA requires data from multiple investigators, review board approvals, clear communication with collaborators, and statistical recalculation of cumulative data. IPD-MA can be performed as a single-stage process where data from all included studies is pooled and reanalysed or as a two-stage process where additionally the data from individual studies is re-analysed before being pooled. This review aims to orient clinicians about IPD-MA, including the process of performing it, comparing it with other types of meta-analyses and considering the potential barriers in conducting it.https://journals.lww.com/10.4103/ija.ija_1187_24aggregate dataevidence-based medicineindividual participant datameta-analysisresearch methodologysystematic review |
| spellingShingle | Ekta Rai Vibhavari Naik Aparna Williams Mohan S. Kamath Individual participant data (IPD) meta-analysis: An introduction – Narrative review Indian Journal of Anaesthesia aggregate data evidence-based medicine individual participant data meta-analysis research methodology systematic review |
| title | Individual participant data (IPD) meta-analysis: An introduction – Narrative review |
| title_full | Individual participant data (IPD) meta-analysis: An introduction – Narrative review |
| title_fullStr | Individual participant data (IPD) meta-analysis: An introduction – Narrative review |
| title_full_unstemmed | Individual participant data (IPD) meta-analysis: An introduction – Narrative review |
| title_short | Individual participant data (IPD) meta-analysis: An introduction – Narrative review |
| title_sort | individual participant data ipd meta analysis an introduction narrative review |
| topic | aggregate data evidence-based medicine individual participant data meta-analysis research methodology systematic review |
| url | https://journals.lww.com/10.4103/ija.ija_1187_24 |
| work_keys_str_mv | AT ektarai individualparticipantdataipdmetaanalysisanintroductionnarrativereview AT vibhavarinaik individualparticipantdataipdmetaanalysisanintroductionnarrativereview AT aparnawilliams individualparticipantdataipdmetaanalysisanintroductionnarrativereview AT mohanskamath individualparticipantdataipdmetaanalysisanintroductionnarrativereview |