Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review
Knee osteoarthritis (OA) is a chronic degenerative disorder which could be distinguished by erosion of articular cartilage, pain, stiffness, and crepitus. Not only aging-associated alterations but also the metabolic factors such as hyperglycemia, dyslipidemia, and obesity affect articular tissues an...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/5421019 |
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| author | Navneet Kumar Dubey Viraj Krishna Mishra Rajni Dubey Shabbir Syed-Abdul Joseph R. Wang Peter D. Wang Win-Ping Deng |
| author_facet | Navneet Kumar Dubey Viraj Krishna Mishra Rajni Dubey Shabbir Syed-Abdul Joseph R. Wang Peter D. Wang Win-Ping Deng |
| author_sort | Navneet Kumar Dubey |
| collection | DOAJ |
| description | Knee osteoarthritis (OA) is a chronic degenerative disorder which could be distinguished by erosion of articular cartilage, pain, stiffness, and crepitus. Not only aging-associated alterations but also the metabolic factors such as hyperglycemia, dyslipidemia, and obesity affect articular tissues and may initiate or exacerbate the OA. The poor self-healing ability of articular cartilage due to limited regeneration in chondrocytes further adversely affects the osteoarthritic microenvironment. Traditional and current surgical treatment procedures for OA are limited and incapable to reverse the damage of articular cartilage. To overcome these limitations, cell-based therapies are currently being employed to repair and regenerate the structure and function of articular tissues. These therapies not only depend upon source and type of stem cells but also on environmental conditions, growth factors, and chemical and mechanical stimuli. Recently, the pluripotent and various multipotent mesenchymal stem cells have been employed for OA therapy, due to their differentiation potential towards chondrogenic lineage. Additionally, the stem cells have also been supplemented with growth factors to achieve higher healing response in osteoarthritic cartilage. In this review, we summarized the current status of stem cell therapies in OA pathophysiology and also highlighted the potential areas of further research needed in regenerative medicine. |
| format | Article |
| id | doaj-art-f263ade77132499dbbfccea88e625886 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f263ade77132499dbbfccea88e6258862025-02-03T05:44:58ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/54210195421019Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A ReviewNavneet Kumar Dubey0Viraj Krishna Mishra1Rajni Dubey2Shabbir Syed-Abdul3Joseph R. Wang4Peter D. Wang5Win-Ping Deng6Ceramics and Biomaterials Research Group, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, VietnamApplied Biotech Engineering Centre (ABEC), Department of Biotechnology, Ambala College of Engineering and Applied Research, Ambala, IndiaGraduate Institute of Food Science and Technology, National Taiwan University, Taipei, TaiwanGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanDepartment of Periodontics, College of Dental Medicine, Columbia University, New York, NY, USASchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, TaiwanFaculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, VietnamKnee osteoarthritis (OA) is a chronic degenerative disorder which could be distinguished by erosion of articular cartilage, pain, stiffness, and crepitus. Not only aging-associated alterations but also the metabolic factors such as hyperglycemia, dyslipidemia, and obesity affect articular tissues and may initiate or exacerbate the OA. The poor self-healing ability of articular cartilage due to limited regeneration in chondrocytes further adversely affects the osteoarthritic microenvironment. Traditional and current surgical treatment procedures for OA are limited and incapable to reverse the damage of articular cartilage. To overcome these limitations, cell-based therapies are currently being employed to repair and regenerate the structure and function of articular tissues. These therapies not only depend upon source and type of stem cells but also on environmental conditions, growth factors, and chemical and mechanical stimuli. Recently, the pluripotent and various multipotent mesenchymal stem cells have been employed for OA therapy, due to their differentiation potential towards chondrogenic lineage. Additionally, the stem cells have also been supplemented with growth factors to achieve higher healing response in osteoarthritic cartilage. In this review, we summarized the current status of stem cell therapies in OA pathophysiology and also highlighted the potential areas of further research needed in regenerative medicine.http://dx.doi.org/10.1155/2018/5421019 |
| spellingShingle | Navneet Kumar Dubey Viraj Krishna Mishra Rajni Dubey Shabbir Syed-Abdul Joseph R. Wang Peter D. Wang Win-Ping Deng Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review Stem Cells International |
| title | Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review |
| title_full | Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review |
| title_fullStr | Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review |
| title_full_unstemmed | Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review |
| title_short | Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review |
| title_sort | combating osteoarthritis through stem cell therapies by rejuvenating cartilage a review |
| url | http://dx.doi.org/10.1155/2018/5421019 |
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