Comparative Effects of Candesartan Versus Enalapril on Apelin, Visfatin, and Lipid Levels in Non-obese Hypertensive Patients
Objective: Apelin and visfatin are adipokines secreted from adipose tissue that play important roles in regulating blood pressure. Therefore, the current study aimed to investigate the effects of candesartan versus enalapril on apelin, visfatin, and lipid profiles in hypertensive patients. Methods:...
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Galenos Publishing House
2024-09-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-16098 |
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| author | Yaseen K. JUMAAH Zainab H. FATHI Jehan A. MOHAMMAD |
| author_facet | Yaseen K. JUMAAH Zainab H. FATHI Jehan A. MOHAMMAD |
| author_sort | Yaseen K. JUMAAH |
| collection | DOAJ |
| description | Objective: Apelin and visfatin are adipokines secreted from adipose tissue that play important roles in regulating blood pressure. Therefore, the current study aimed to investigate the effects of candesartan versus enalapril on apelin, visfatin, and lipid profiles in hypertensive patients.
Methods: In this case-control study, 120 participants were enrolled in four groups; Healthy people, newly diagnosed hypertensive patients, and enalapril- and candesartan-treated patients.
Results: Serum apelin levels were significantly lower and visfatin levels were significantly higher in newly diagnosed hypertensive patients compared with the control group (p=0.0015, p=0.0175 respectively). Moreover, apelin levels were higher and visfatin levels were lower in the candesartan-treated patients compared with the newly diagnosed group (p=0.0487, p<0.0001 respectively). Interestingly, apelin levels were nonsignificantly higher and visfatin levels were significantly lower in enalapriltreated patients compared with the newly diagnosed group (p<0.0001).
Conclusions: Lower apelin and higher visfatin levels are associated with newly diagnosed patients with hypertension. Interestingly, the findings suggest that ACE inhibition and angiotensin receptor blockade by enalapril and candesartan, respectively, positively regulate apelin and visfatin levels in hypertension. Specifically, candesartan regulates these adipokine to a greater extent than enalapril. |
| format | Article |
| id | doaj-art-f252a7bd0d004a56a2092d4f64131e8d |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-f252a7bd0d004a56a2092d4f64131e8d2025-01-29T10:22:46ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062024-09-0139320421010.4274/MMJ.galenos.2024.16098MEDJ-16098Comparative Effects of Candesartan Versus Enalapril on Apelin, Visfatin, and Lipid Levels in Non-obese Hypertensive PatientsYaseen K. JUMAAH0Zainab H. FATHI1Jehan A. MOHAMMAD2University of Mosul, College of Pharmacy, Department of Pharmacognosy and Medicinal Plants, Mosul, IraqUniversity of Mosul, College of Pharmacy, Department of Pharmacognosy and Medicinal Plants, Mosul, IraqUniversity of Mosul, College of Pharmacy, Department of Pharmacognosy and Medicinal Plants, Mosul, IraqObjective: Apelin and visfatin are adipokines secreted from adipose tissue that play important roles in regulating blood pressure. Therefore, the current study aimed to investigate the effects of candesartan versus enalapril on apelin, visfatin, and lipid profiles in hypertensive patients. Methods: In this case-control study, 120 participants were enrolled in four groups; Healthy people, newly diagnosed hypertensive patients, and enalapril- and candesartan-treated patients. Results: Serum apelin levels were significantly lower and visfatin levels were significantly higher in newly diagnosed hypertensive patients compared with the control group (p=0.0015, p=0.0175 respectively). Moreover, apelin levels were higher and visfatin levels were lower in the candesartan-treated patients compared with the newly diagnosed group (p=0.0487, p<0.0001 respectively). Interestingly, apelin levels were nonsignificantly higher and visfatin levels were significantly lower in enalapriltreated patients compared with the newly diagnosed group (p<0.0001). Conclusions: Lower apelin and higher visfatin levels are associated with newly diagnosed patients with hypertension. Interestingly, the findings suggest that ACE inhibition and angiotensin receptor blockade by enalapril and candesartan, respectively, positively regulate apelin and visfatin levels in hypertension. Specifically, candesartan regulates these adipokine to a greater extent than enalapril.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-16098apelinvisfatinlipidhypertensioncandesartanenalapril |
| spellingShingle | Yaseen K. JUMAAH Zainab H. FATHI Jehan A. MOHAMMAD Comparative Effects of Candesartan Versus Enalapril on Apelin, Visfatin, and Lipid Levels in Non-obese Hypertensive Patients Medeniyet Medical Journal apelin visfatin lipid hypertension candesartan enalapril |
| title | Comparative Effects of Candesartan Versus Enalapril on Apelin, Visfatin, and Lipid Levels in Non-obese Hypertensive Patients |
| title_full | Comparative Effects of Candesartan Versus Enalapril on Apelin, Visfatin, and Lipid Levels in Non-obese Hypertensive Patients |
| title_fullStr | Comparative Effects of Candesartan Versus Enalapril on Apelin, Visfatin, and Lipid Levels in Non-obese Hypertensive Patients |
| title_full_unstemmed | Comparative Effects of Candesartan Versus Enalapril on Apelin, Visfatin, and Lipid Levels in Non-obese Hypertensive Patients |
| title_short | Comparative Effects of Candesartan Versus Enalapril on Apelin, Visfatin, and Lipid Levels in Non-obese Hypertensive Patients |
| title_sort | comparative effects of candesartan versus enalapril on apelin visfatin and lipid levels in non obese hypertensive patients |
| topic | apelin visfatin lipid hypertension candesartan enalapril |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-16098 |
| work_keys_str_mv | AT yaseenkjumaah comparativeeffectsofcandesartanversusenalaprilonapelinvisfatinandlipidlevelsinnonobesehypertensivepatients AT zainabhfathi comparativeeffectsofcandesartanversusenalaprilonapelinvisfatinandlipidlevelsinnonobesehypertensivepatients AT jehanamohammad comparativeeffectsofcandesartanversusenalaprilonapelinvisfatinandlipidlevelsinnonobesehypertensivepatients |