Reversible Manifestations of Hypothyroidism causing Diagnostic Dilemma: A Case Series
Hypothyroidism causes a wide spectrum of clinical manifestations, with various signs and symptoms. Some symptoms are common and aid in diagnosis, while the uncommon manifestations may be the sole feature causing diagnostic delays, leading to increased morbidity and mortality. Hereby the authors pres...
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JCDR Research and Publications Private Limited
2025-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/20538/76355_CE[Ra1]_F(SHU)_QC(PS_SHU)_PF1(RI_SL)_PFA_NC(IS)_PN(IS).pdf |
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| author | Kaushik Hazra Somnath Maitra Sunetra Roy Isha Ghosh |
| author_facet | Kaushik Hazra Somnath Maitra Sunetra Roy Isha Ghosh |
| author_sort | Kaushik Hazra |
| collection | DOAJ |
| description | Hypothyroidism causes a wide spectrum of clinical manifestations, with various signs and symptoms. Some symptoms are common and aid in diagnosis, while the uncommon manifestations may be the sole feature causing diagnostic delays, leading to increased morbidity and mortality. Hereby the authors present a combination of three cases (50-year-old female, 22-year-old female, 56-year-old female): ascites, congenital hypothyroidism and myxoedema coma, respectively. Ascites in hypothyroidism responds to treatment and can help avoid unnecessary investigations; however, since this presentation is rare, clinicians should remain alert for low Serum Ascites Albumin Gradient (SAAG) with high protein ascites. myxoedema coma was diagnosed after excluding cerebrovascular accident, sepsis and dyselectrolytemia, with low body temperature serving as a diagnostic clue. Congenital hypothyroidism should be identified and treated promptly to prevent complications in newborns, as thyroid hormone is crucial for growth and development. Deficiency may lead to severe complications in newborns, so it is essential to rule out other causes. The importance of the present case series lies in the fact that hypothyroidism may present with variable manifestations. It is crucial to identify this hormone deficiency, as replacement with widely available thyroid hormone supplementation can promptly reverse some of the clinical manifestations, thereby aiding in accurate diagnosis and timely management with appropriate therapy. |
| format | Article |
| id | doaj-art-f236e6acf13141c082e8fe8d5749a022 |
| institution | Kabale University |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-f236e6acf13141c082e8fe8d5749a0222025-01-27T11:33:14ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2025-01-011901060910.7860/JCDR/2025/76355.20538Reversible Manifestations of Hypothyroidism causing Diagnostic Dilemma: A Case SeriesKaushik Hazra0Somnath Maitra1Sunetra Roy2Isha Ghosh3Associate Professor, Department of General Medicine, Jagannath Gupta Institute of Medical Sciences and Hospital, Budge, West Bengal, India.Professor, Department of General Medicine, Jagannath Gupta Institute of Medical Sciences and Hospital, Budge, West Bengal, India.Assistant Professor, Department of Paediatrics, Jagannath Gupta Institute of Medical Sciences and Hospital, Budge, West Bengal, India.Third-Year Postgraduate Trainee, Department of General Medicine, Jagannath Gupta Institute of Medical Sciences and Hospital, Budge, West Bengal, India.Hypothyroidism causes a wide spectrum of clinical manifestations, with various signs and symptoms. Some symptoms are common and aid in diagnosis, while the uncommon manifestations may be the sole feature causing diagnostic delays, leading to increased morbidity and mortality. Hereby the authors present a combination of three cases (50-year-old female, 22-year-old female, 56-year-old female): ascites, congenital hypothyroidism and myxoedema coma, respectively. Ascites in hypothyroidism responds to treatment and can help avoid unnecessary investigations; however, since this presentation is rare, clinicians should remain alert for low Serum Ascites Albumin Gradient (SAAG) with high protein ascites. myxoedema coma was diagnosed after excluding cerebrovascular accident, sepsis and dyselectrolytemia, with low body temperature serving as a diagnostic clue. Congenital hypothyroidism should be identified and treated promptly to prevent complications in newborns, as thyroid hormone is crucial for growth and development. Deficiency may lead to severe complications in newborns, so it is essential to rule out other causes. The importance of the present case series lies in the fact that hypothyroidism may present with variable manifestations. It is crucial to identify this hormone deficiency, as replacement with widely available thyroid hormone supplementation can promptly reverse some of the clinical manifestations, thereby aiding in accurate diagnosis and timely management with appropriate therapy.https://www.jcdr.net/articles/PDF/20538/76355_CE[Ra1]_F(SHU)_QC(PS_SHU)_PF1(RI_SL)_PFA_NC(IS)_PN(IS).pdfascitescomacongenital hypothyroidismserum ascites albumin gradient |
| spellingShingle | Kaushik Hazra Somnath Maitra Sunetra Roy Isha Ghosh Reversible Manifestations of Hypothyroidism causing Diagnostic Dilemma: A Case Series Journal of Clinical and Diagnostic Research ascites coma congenital hypothyroidism serum ascites albumin gradient |
| title | Reversible Manifestations of Hypothyroidism causing Diagnostic Dilemma: A Case Series |
| title_full | Reversible Manifestations of Hypothyroidism causing Diagnostic Dilemma: A Case Series |
| title_fullStr | Reversible Manifestations of Hypothyroidism causing Diagnostic Dilemma: A Case Series |
| title_full_unstemmed | Reversible Manifestations of Hypothyroidism causing Diagnostic Dilemma: A Case Series |
| title_short | Reversible Manifestations of Hypothyroidism causing Diagnostic Dilemma: A Case Series |
| title_sort | reversible manifestations of hypothyroidism causing diagnostic dilemma a case series |
| topic | ascites coma congenital hypothyroidism serum ascites albumin gradient |
| url | https://www.jcdr.net/articles/PDF/20538/76355_CE[Ra1]_F(SHU)_QC(PS_SHU)_PF1(RI_SL)_PFA_NC(IS)_PN(IS).pdf |
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