Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice
Malaria is a major public health problem in the world because it can cause of death in patients. Malaria-associated renal injury is associated with 45% of mortality in adult patients hospitalized with severe form of the disease. Therefore, new plant extracts to protect against renal injury induced b...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/961205 |
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| author | Voravuth Somsak Sukanya Chachiyo Ubonwan Jaihan Somrudee Nakinchat |
| author_facet | Voravuth Somsak Sukanya Chachiyo Ubonwan Jaihan Somrudee Nakinchat |
| author_sort | Voravuth Somsak |
| collection | DOAJ |
| description | Malaria is a major public health problem in the world because it can cause of death in patients. Malaria-associated renal injury is associated with 45% of mortality in adult patients hospitalized with severe form of the disease. Therefore, new plant extracts to protect against renal injury induced by malaria infection are urgently needed. In this study, we investigated the protective effect of aqueous crude extract of Azadirachta indica (neem) leaves on renal injury induced by Plasmodium berghei ANKA infection in mice. ICR mice were injected intraperitoneally with 1 × 107 parasitized erythrocytes of PbANKA, and neem extracts (500, 1,000, and 2,000 mg/kg) were given orally for 4 consecutive days. Plasma blood urea nitrogen (BUN) and creatinine levels were subsequently measured. Malaria-induced renal injury was evidenced as marked increases of BUN and creatinine levels. However, the oral administration of neem leaf extract to PbANKA infected mice for 4 days brought back BUN and creatinine levels to near normalcy, and the highest activity was observed at doses of 1,000 and 2,000 mg/kg. Additionally, no toxic effects were found in normal mice treated with this extract. Hence, neem leaf extract can be considered a potential candidate for protection against renal injury induced by malaria. |
| format | Article |
| id | doaj-art-f235f4a1cd0e41b5987ec68533b980c9 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-f235f4a1cd0e41b5987ec68533b980c92025-02-03T05:58:19ZengWileyJournal of Tropical Medicine1687-96861687-96942015-01-01201510.1155/2015/961205961205Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in MiceVoravuth Somsak0Sukanya Chachiyo1Ubonwan Jaihan2Somrudee Nakinchat3Department of Clinical Chemistry, Faculty of Medical Technology, Western University, Kanchanaburi 71170, ThailandDepartment of Clinical Chemistry, Faculty of Medical Technology, Western University, Kanchanaburi 71170, ThailandDepartment of Clinical Chemistry, Faculty of Medical Technology, Western University, Kanchanaburi 71170, ThailandDepartment of Clinical Chemistry, Faculty of Medical Technology, Western University, Kanchanaburi 71170, ThailandMalaria is a major public health problem in the world because it can cause of death in patients. Malaria-associated renal injury is associated with 45% of mortality in adult patients hospitalized with severe form of the disease. Therefore, new plant extracts to protect against renal injury induced by malaria infection are urgently needed. In this study, we investigated the protective effect of aqueous crude extract of Azadirachta indica (neem) leaves on renal injury induced by Plasmodium berghei ANKA infection in mice. ICR mice were injected intraperitoneally with 1 × 107 parasitized erythrocytes of PbANKA, and neem extracts (500, 1,000, and 2,000 mg/kg) were given orally for 4 consecutive days. Plasma blood urea nitrogen (BUN) and creatinine levels were subsequently measured. Malaria-induced renal injury was evidenced as marked increases of BUN and creatinine levels. However, the oral administration of neem leaf extract to PbANKA infected mice for 4 days brought back BUN and creatinine levels to near normalcy, and the highest activity was observed at doses of 1,000 and 2,000 mg/kg. Additionally, no toxic effects were found in normal mice treated with this extract. Hence, neem leaf extract can be considered a potential candidate for protection against renal injury induced by malaria.http://dx.doi.org/10.1155/2015/961205 |
| spellingShingle | Voravuth Somsak Sukanya Chachiyo Ubonwan Jaihan Somrudee Nakinchat Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice Journal of Tropical Medicine |
| title | Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice |
| title_full | Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice |
| title_fullStr | Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice |
| title_full_unstemmed | Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice |
| title_short | Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice |
| title_sort | protective effect of aqueous crude extract of neem azadirachta indica leaves on plasmodium berghei induced renal damage in mice |
| url | http://dx.doi.org/10.1155/2015/961205 |
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