Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction
Iron chelation therapy (ICT) has been applied for the patients with iron overload-associated liver dysfunction since it is one of the causes of death in patients with intractable hematological diseases requiring multiple red blood cell transfusions. Recently, deferasirox (DSX), a novel, once-daily o...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/675060 |
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| author | Yasuo Miura Yusuke Matsui Hitomi Kaneko Mitsumasa Watanabe Mitsuru Tsudo |
| author_facet | Yasuo Miura Yusuke Matsui Hitomi Kaneko Mitsumasa Watanabe Mitsuru Tsudo |
| author_sort | Yasuo Miura |
| collection | DOAJ |
| description | Iron chelation therapy (ICT) has been applied for the patients with iron overload-associated liver dysfunction since it is one of the causes of death in patients with intractable hematological diseases requiring multiple red blood cell transfusions. Recently, deferasirox (DSX), a novel, once-daily oral iron chelator, was demonstrated to have similar efficacy to the conventional continuous infusion of deferoxamine on a decrease in serum ferritin (SF) level in heavily transfused patients. We show three cases of transfusion-mediated iron-overloaded patients with an elevated serum alanine aminotransaminase (ALT). All three patients who received the ICT with DSX showed a decrease in ALT level in association with a decrease in SF level. It is suggested that DSX therapy could be considered to expect the improvement of liver damage for iron-overloaded patients with an abnormal ALT level. |
| format | Article |
| id | doaj-art-f2328a4f2b8743bda1fc2e7da77cb5c4 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-f2328a4f2b8743bda1fc2e7da77cb5c42025-02-03T01:22:04ZengWileyCase Reports in Medicine1687-96271687-96352010-01-01201010.1155/2010/675060675060Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver DysfunctionYasuo Miura0Yusuke Matsui1Hitomi Kaneko2Mitsumasa Watanabe3Mitsuru Tsudo4Department of Hematology, Osaka Red Cross Hospital, 5-30 Fudegasaki, Ten-noji, Osaka 543-8555, JapanDepartment of Hematology, Osaka Red Cross Hospital, 5-30 Fudegasaki, Ten-noji, Osaka 543-8555, JapanDepartment of Hematology, Osaka Red Cross Hospital, 5-30 Fudegasaki, Ten-noji, Osaka 543-8555, JapanDepartment of Hematology, Osaka Red Cross Hospital, 5-30 Fudegasaki, Ten-noji, Osaka 543-8555, JapanDepartment of Hematology, Osaka Red Cross Hospital, 5-30 Fudegasaki, Ten-noji, Osaka 543-8555, JapanIron chelation therapy (ICT) has been applied for the patients with iron overload-associated liver dysfunction since it is one of the causes of death in patients with intractable hematological diseases requiring multiple red blood cell transfusions. Recently, deferasirox (DSX), a novel, once-daily oral iron chelator, was demonstrated to have similar efficacy to the conventional continuous infusion of deferoxamine on a decrease in serum ferritin (SF) level in heavily transfused patients. We show three cases of transfusion-mediated iron-overloaded patients with an elevated serum alanine aminotransaminase (ALT). All three patients who received the ICT with DSX showed a decrease in ALT level in association with a decrease in SF level. It is suggested that DSX therapy could be considered to expect the improvement of liver damage for iron-overloaded patients with an abnormal ALT level.http://dx.doi.org/10.1155/2010/675060 |
| spellingShingle | Yasuo Miura Yusuke Matsui Hitomi Kaneko Mitsumasa Watanabe Mitsuru Tsudo Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction Case Reports in Medicine |
| title | Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction |
| title_full | Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction |
| title_fullStr | Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction |
| title_full_unstemmed | Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction |
| title_short | Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction |
| title_sort | iron chelation therapy with deferasirox results in improvement of liver enzyme level in patients with iron overload associated liver dysfunction |
| url | http://dx.doi.org/10.1155/2010/675060 |
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