Dynamics of the mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis

Dynamics of the mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis

Abstract The multi-enzyme pyruvate dehydrogenase complex (PDHc) links glycolysis to the citric acid cycle and plays vital roles in metabolism, energy production, and cellular signaling. Although all components have been individually characterized, the intact PDHc structure remains unclear, hampering...

Full description

Saved in:
Bibliographic Details
Main Authors: Chen Wang, Cheng Ma, Yuanyou Xu, Shenghai Chang, Hangjun Wu, Chunlan Yan, Jinghua Chen, Yongping Wu, Shaoya An, Jiaqi Xu, Qin Han, Yujie Jiang, Zhinong Jiang, Xiakun Chu, Haichun Gao, Xing Zhang, Yunjie Chang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56171-8
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items