Cesarean delivery on child health and development in Japanese nationwide birth cohort
Abstract The long-term effects of cesarean delivery (CD) on child health and development remain controversial. This study aimed to investigate these effects using an outcome-wide approach in a Japanese context, where perinatal mortality rates are among the world’s lowest. We analyzed data from 2,114...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-87043-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585886460542976 |
|---|---|
| author | Naomi Matsumoto Takashi Mitsui Kei Tamai Tomoya Hirota Hisashi Masuyama Takashi Yorifuji |
| author_facet | Naomi Matsumoto Takashi Mitsui Kei Tamai Tomoya Hirota Hisashi Masuyama Takashi Yorifuji |
| author_sort | Naomi Matsumoto |
| collection | DOAJ |
| description | Abstract The long-term effects of cesarean delivery (CD) on child health and development remain controversial. This study aimed to investigate these effects using an outcome-wide approach in a Japanese context, where perinatal mortality rates are among the world’s lowest. We analyzed data from 2,114 children in a nationwide Japanese birth cohort, linking the 21st Century Longitudinal Survey of Newborns with the Perinatal Research Network database. We examined associations between CD and various health and developmental outcomes up to 9 years of age, including hospitalizations, obesity, and developmental milestones. After adjusting for potential confounders, CD was not significantly associated with most outcomes, including all-cause hospitalization (adjusted risk ratio 1.25, 95% CI 0.997–1.56), obesity at 5.5 and 9 years, and various developmental milestones. Subgroup analyses for multiple births and preterm infants showed some differences in point estimates, but were limited by small sample sizes. CD was not significantly associated with adverse long-term child health or developmental outcomes in this Japanese cohort. These findings provide reassurance regarding CD safety when medically indicated in advanced perinatal care settings. Further research with larger samples and longer follow-up is needed, especially for specific subgroups. |
| format | Article |
| id | doaj-art-f22d8349cf3b46f795f7fccbc9e45ea9 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-f22d8349cf3b46f795f7fccbc9e45ea92025-01-26T12:27:48ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-025-87043-2Cesarean delivery on child health and development in Japanese nationwide birth cohortNaomi Matsumoto0Takashi Mitsui1Kei Tamai2Tomoya Hirota3Hisashi Masuyama4Takashi Yorifuji5Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama UniversityDepartment of Obstetrics and Gynecology, Okayama University Graduate School of MedicineDivision of Neonatology, NHO Okayama Medical CenterDepartment of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California San FranciscoDepartment of Obstetrics and Gynecology, Okayama University Graduate School of MedicineDepartment of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama UniversityAbstract The long-term effects of cesarean delivery (CD) on child health and development remain controversial. This study aimed to investigate these effects using an outcome-wide approach in a Japanese context, where perinatal mortality rates are among the world’s lowest. We analyzed data from 2,114 children in a nationwide Japanese birth cohort, linking the 21st Century Longitudinal Survey of Newborns with the Perinatal Research Network database. We examined associations between CD and various health and developmental outcomes up to 9 years of age, including hospitalizations, obesity, and developmental milestones. After adjusting for potential confounders, CD was not significantly associated with most outcomes, including all-cause hospitalization (adjusted risk ratio 1.25, 95% CI 0.997–1.56), obesity at 5.5 and 9 years, and various developmental milestones. Subgroup analyses for multiple births and preterm infants showed some differences in point estimates, but were limited by small sample sizes. CD was not significantly associated with adverse long-term child health or developmental outcomes in this Japanese cohort. These findings provide reassurance regarding CD safety when medically indicated in advanced perinatal care settings. Further research with larger samples and longer follow-up is needed, especially for specific subgroups.https://doi.org/10.1038/s41598-025-87043-2Cesarean deliveryDelivery methodsLong-term outcomeChild developmentOutcome-wide approach |
| spellingShingle | Naomi Matsumoto Takashi Mitsui Kei Tamai Tomoya Hirota Hisashi Masuyama Takashi Yorifuji Cesarean delivery on child health and development in Japanese nationwide birth cohort Scientific Reports Cesarean delivery Delivery methods Long-term outcome Child development Outcome-wide approach |
| title | Cesarean delivery on child health and development in Japanese nationwide birth cohort |
| title_full | Cesarean delivery on child health and development in Japanese nationwide birth cohort |
| title_fullStr | Cesarean delivery on child health and development in Japanese nationwide birth cohort |
| title_full_unstemmed | Cesarean delivery on child health and development in Japanese nationwide birth cohort |
| title_short | Cesarean delivery on child health and development in Japanese nationwide birth cohort |
| title_sort | cesarean delivery on child health and development in japanese nationwide birth cohort |
| topic | Cesarean delivery Delivery methods Long-term outcome Child development Outcome-wide approach |
| url | https://doi.org/10.1038/s41598-025-87043-2 |
| work_keys_str_mv | AT naomimatsumoto cesareandeliveryonchildhealthanddevelopmentinjapanesenationwidebirthcohort AT takashimitsui cesareandeliveryonchildhealthanddevelopmentinjapanesenationwidebirthcohort AT keitamai cesareandeliveryonchildhealthanddevelopmentinjapanesenationwidebirthcohort AT tomoyahirota cesareandeliveryonchildhealthanddevelopmentinjapanesenationwidebirthcohort AT hisashimasuyama cesareandeliveryonchildhealthanddevelopmentinjapanesenationwidebirthcohort AT takashiyorifuji cesareandeliveryonchildhealthanddevelopmentinjapanesenationwidebirthcohort |