HDL Subclass Distribution Shifts with Increasing Central Adiposity
Although cross-sectional studies have shown that obesity is associated with lower concentrations of large high-density lipoprotein (HDL) subclasses, it is unknown if changes in HDL subclasses are related to changes in body fat and its distribution over time. We therefore assessed changes in HDL subc...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2019/2107178 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549552523051008 |
|---|---|
| author | Nicholas J. Woudberg Sandrine Lecour Julia H. Goedecke |
| author_facet | Nicholas J. Woudberg Sandrine Lecour Julia H. Goedecke |
| author_sort | Nicholas J. Woudberg |
| collection | DOAJ |
| description | Although cross-sectional studies have shown that obesity is associated with lower concentrations of large high-density lipoprotein (HDL) subclasses, it is unknown if changes in HDL subclasses are related to changes in body fat and its distribution over time. We therefore assessed changes in HDL subclass distribution over a 5.5-year free-living follow-up period in 24 black South African women. At baseline and follow-up, body composition and body fat distribution were measured using anthropometry, dual X-ray absorptiometry, and computerized tomography. HDL subclass distribution was quantified using Lipoprint®. Over the 5.5-year follow-up period, body fat (+17.3 ± 4.5 kg, p<0.05) and trunk fat mass (+7.4 ± 1.9%, % fat mass, FM, p<0.05) increased, while leg fat mass (−2.53 ± 0.56%, % FM, p<0.001) and the distribution of large (−6.43 ± 2.12%, p<0.05) HDL subclasses decreased. A percentage decrease in large HDL subclasses was associated with a percentage increase in central fat mass (visceral adipose tissue (VAT) area, p<0.05) and a percentage decrease in peripheral fat mass (leg fat mass). These preliminary findings suggest that a relative redistribution of body fat from the periphery to the abdominal region were associated with a decrease HDL subclass size in black South African women and provide a novel link between body fat distribution and lipidology in this population. |
| format | Article |
| id | doaj-art-f22c2be4b28945ada447c7f78374b50a |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-f22c2be4b28945ada447c7f78374b50a2025-02-03T06:11:11ZengWileyJournal of Obesity2090-07082090-07162019-01-01201910.1155/2019/21071782107178HDL Subclass Distribution Shifts with Increasing Central AdiposityNicholas J. Woudberg0Sandrine Lecour1Julia H. Goedecke2Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaHatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaNon-Communicable Diseases Research Unit, South African Medical Research Council, Parow Valley, Cape Town, South AfricaAlthough cross-sectional studies have shown that obesity is associated with lower concentrations of large high-density lipoprotein (HDL) subclasses, it is unknown if changes in HDL subclasses are related to changes in body fat and its distribution over time. We therefore assessed changes in HDL subclass distribution over a 5.5-year free-living follow-up period in 24 black South African women. At baseline and follow-up, body composition and body fat distribution were measured using anthropometry, dual X-ray absorptiometry, and computerized tomography. HDL subclass distribution was quantified using Lipoprint®. Over the 5.5-year follow-up period, body fat (+17.3 ± 4.5 kg, p<0.05) and trunk fat mass (+7.4 ± 1.9%, % fat mass, FM, p<0.05) increased, while leg fat mass (−2.53 ± 0.56%, % FM, p<0.001) and the distribution of large (−6.43 ± 2.12%, p<0.05) HDL subclasses decreased. A percentage decrease in large HDL subclasses was associated with a percentage increase in central fat mass (visceral adipose tissue (VAT) area, p<0.05) and a percentage decrease in peripheral fat mass (leg fat mass). These preliminary findings suggest that a relative redistribution of body fat from the periphery to the abdominal region were associated with a decrease HDL subclass size in black South African women and provide a novel link between body fat distribution and lipidology in this population.http://dx.doi.org/10.1155/2019/2107178 |
| spellingShingle | Nicholas J. Woudberg Sandrine Lecour Julia H. Goedecke HDL Subclass Distribution Shifts with Increasing Central Adiposity Journal of Obesity |
| title | HDL Subclass Distribution Shifts with Increasing Central Adiposity |
| title_full | HDL Subclass Distribution Shifts with Increasing Central Adiposity |
| title_fullStr | HDL Subclass Distribution Shifts with Increasing Central Adiposity |
| title_full_unstemmed | HDL Subclass Distribution Shifts with Increasing Central Adiposity |
| title_short | HDL Subclass Distribution Shifts with Increasing Central Adiposity |
| title_sort | hdl subclass distribution shifts with increasing central adiposity |
| url | http://dx.doi.org/10.1155/2019/2107178 |
| work_keys_str_mv | AT nicholasjwoudberg hdlsubclassdistributionshiftswithincreasingcentraladiposity AT sandrinelecour hdlsubclassdistributionshiftswithincreasingcentraladiposity AT juliahgoedecke hdlsubclassdistributionshiftswithincreasingcentraladiposity |