Update on Ppar𝜸 and Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is the most common initial presentation of obesity and insulin resistance. Uninterrupted progression of hepatic lipid accumulation often leads to fatty liver disease and eventually cirrhosis. Insulin resistance is one of the characteristics of type 2 diabetes...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/912351 |
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| author | Gene P. Ables |
| author_facet | Gene P. Ables |
| author_sort | Gene P. Ables |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is the most common initial presentation of obesity and insulin resistance. Uninterrupted progression of hepatic lipid accumulation often leads to fatty liver disease and eventually cirrhosis. Insulin resistance is one of the characteristics of type 2 diabetes. Several types of treatment have been employed against type 2 diabetes some of which ameliorate NAFLD. The frequent line of treatment to improve insulin sensitivity is the use of thiazolidinediones (TZD) which activate the nuclear receptor, peroxisome proliferator activated receptor gamma (Pparγ). Although TZDs are proven to be very effective in promoting insulin sensitivity, its actions on Pparγ have been complicated, specifically on NAFLD. According to studies in different models, Pparγ manifests both beneficial and undesirable effects on NAFLD. This paper will focus on the current knowledge of Pparγ and its effect on NAFLD. |
| format | Article |
| id | doaj-art-f219d3009dc94d7bb64e2e8f6234b063 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-f219d3009dc94d7bb64e2e8f6234b0632025-02-03T01:22:37ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/912351912351Update on Ppar𝜸 and Nonalcoholic Fatty Liver DiseaseGene P. Ables0Animal Science Laboratory, Orentreich Foundation for the Advancement of Science, 855 Route 301, Cold Spring, NY 10516, USANonalcoholic fatty liver disease (NAFLD) is the most common initial presentation of obesity and insulin resistance. Uninterrupted progression of hepatic lipid accumulation often leads to fatty liver disease and eventually cirrhosis. Insulin resistance is one of the characteristics of type 2 diabetes. Several types of treatment have been employed against type 2 diabetes some of which ameliorate NAFLD. The frequent line of treatment to improve insulin sensitivity is the use of thiazolidinediones (TZD) which activate the nuclear receptor, peroxisome proliferator activated receptor gamma (Pparγ). Although TZDs are proven to be very effective in promoting insulin sensitivity, its actions on Pparγ have been complicated, specifically on NAFLD. According to studies in different models, Pparγ manifests both beneficial and undesirable effects on NAFLD. This paper will focus on the current knowledge of Pparγ and its effect on NAFLD.http://dx.doi.org/10.1155/2012/912351 |
| spellingShingle | Gene P. Ables Update on Ppar𝜸 and Nonalcoholic Fatty Liver Disease PPAR Research |
| title | Update on Ppar𝜸 and Nonalcoholic Fatty Liver Disease |
| title_full | Update on Ppar𝜸 and Nonalcoholic Fatty Liver Disease |
| title_fullStr | Update on Ppar𝜸 and Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Update on Ppar𝜸 and Nonalcoholic Fatty Liver Disease |
| title_short | Update on Ppar𝜸 and Nonalcoholic Fatty Liver Disease |
| title_sort | update on ppar𝜸 and nonalcoholic fatty liver disease |
| url | http://dx.doi.org/10.1155/2012/912351 |
| work_keys_str_mv | AT genepables updateonpparγandnonalcoholicfattyliverdisease |